Patents Assigned to Facet Biotech Corpration
  • ALTERATION OF FC-FUSION PROTEIN SERUM HALF-LIVES BY MUTAGENESIS
    Publication number: 20110183412
    Abstract: The present invention provides for a modified Fc-fusion protein in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified Fc-fusion protein, thereby altering the binding affinity for FcRn and/or the serum half-life in comparison to the unmodified Fc-fusion protein.
    Type: Application
    Filed: March 31, 2010
    Publication date: July 28, 2011
    Applicant: Facet Biotech Corpration
    Inventors: Paul R. Hinton, Naoya Tsurushita