Patents Assigned to FACULDADE DE CIÉNCIAS DA UNIVERSIDADE DE LISBOA
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Publication number: 20230357301Abstract: A compound of formula I: or a salt thereof, wherein: R1 is —OC (H) (X) (CH2)nC(?O)OH; R2 is —OH, —N3, or —N(H)C(?O)CH3; or R1 and R2 together with the carbon atoms to which they are attached form R3 is —H, —CH3, —CH2C(?O)OH, or —CH2OH; X is —H, —CH3, —CH2OH, or CH2C(?O)OH; and n is 0 or 1.Type: ApplicationFiled: June 9, 2023Publication date: November 9, 2023Applicants: Faculdade de Ciencias da Universidade de Lisboa, Instituto de Tecnologia Quimica e Biologica Antonio XavierInventors: Christopher David Maycock, Maria Rita Mendes Bordalo Ventura Centeno Lima, Eva Correia Lourenco, Maria Helena Dias dos Santos, Ana Sofia da Cunha Miguel
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Patent number: 11708387Abstract: A compound of formula I: or a salt thereof, wherein: R1 is —OC(H)(X)(CH2)nC(?O)OH; R2 is —OH, —N3, or —N(H)C(?O)CH3; or R1 and R2 together with the carbon atoms to which they are attached form R3 is —H, —CH3, —CH2C(?O)OH, or —CH2OH; X is —H, —CH3, —CH2OH, or CH2C(?O)OH; and n is 0 or 1.Type: GrantFiled: March 13, 2015Date of Patent: July 25, 2023Assignees: Faculdade de Ciências da Universidade de Lisboa, Instituto De Tecnologia Química E Biológica António XavierInventors: Christopher David Maycock, Maria Rita Mendes Bordalo Ventura Centeno Lima, Eva Correia Lourenço, Maria Helena Dias Dos Santos, Ana Sofia Da Cunha Miguel
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Patent number: 11168179Abstract: The present invention relates to macromolecular transition metal complexes, characterized by having the general formula (I), to the process for their preparation, and to bidentate and monodentate macroligands. The invention also refers to pharmaceutical compositions and medicaments containing said macromolecular transition metal complexes, and to the use of said pharmaceutical compositions, medicaments and macromolecular transition metal complexes for cancer therapy and/or cancer prevention, as antitumor agent in solid tumors, liquid tumors and/or metastases and/or as radiosensitizer agents.Type: GrantFiled: December 7, 2015Date of Patent: November 9, 2021Assignee: FACULDADE DE CIÉNCIAS DA UNIVERSIDADE DE LISBOAInventors: Maria Helena Anselmo Viegas Garcia, Andreia Marques Valente, Tânia Sofia Ferreira Morais, Ana Isabel Antunes Tomaz Diniz
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Publication number: 20180009940Abstract: The present invention relates to macromolecular transition metal complexes, characterized by having the general formula (I), to the process for their preparation, and to bidentate and monodentate macroligands. The invention also refers to pharmaceutical compositions and medicaments containing said macromolecular transition metal complexes, and to the use of said pharmaceutical compositions, medicaments and macromolecular transition metal complexes for cancer therapy and/or cancer prevention, as antitumor agent in solid tumors, liquid tumors and/or metastases and/or as radiosensitizer agents.Type: ApplicationFiled: December 7, 2015Publication date: January 11, 2018Applicant: FACULDADE DE CIÉNCIAS DA UNIVERSIDADE DE LISBOAInventors: Maria Helena ANSELMO VIEGAS GARCIA, Andreia MARQUES VALENTE, Tânia Sofia FERREIRA MORAIS, Ana Isabel ANTUNES TOMAZ DINIZ
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Patent number: 9775856Abstract: The present invention concerns the antidiabetic-activity of compounds type A, namely of 8-?-D-glucosylgenistein, which is not toxic to eukaryotic cells and has demonstrated to produce complete normalization of fasting hyperglycaemia, to reduce excessive postprandial glucose excursion, to increase glucose-induced insulin secretion and insulin sensitivity. An alternative synthesis for this molecular entity and its binding ability to ?-amyloid oligomers is also included in the present invention, which also comprises Genista tenera ethyl acetate extract for use as antihyperglycaemic, agent i.e. for lowering blood glucose levels in mammals that are pre-diabetic or have type 2 or type 1 diabetes. The inhibitory activity of ?-glucosidase by Genista tenera ethyl acetate and butanol extracts and that of glucose-6-phosphatase by these two extracts and the diethyl ether plant extract is also part of the present invention.Type: GrantFiled: March 11, 2013Date of Patent: October 3, 2017Assignee: FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOAInventors: Amélia Pilar Grases Santos Silva Rauter, Ana Rita Xavier De Jesus, Alice Isabel Mendes Martins, Catarina Alexandra Dos Santos Dias, Rogério José Tavares Ribeiro, Maria Paula Borges De Lemos Macedo, Jorge Alberto Guerra Justino, Helder Dias Mota Filipe, Rui Manuel Amaro Pinto, Bruno Miguel Nogueira Sepodes, Margarida Alexandra Patrício Goulart De Medeiros, Jesus Jimenéz Barbero, Cristina Airoldi, Francesco Nicotra
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Patent number: 7917192Abstract: Tomography by emission of positrons (pet) system dedicated to examinations of human body parts such as the breast, axilla, head, neck, liver, heart, lungs, prostate region and other body extremities which is composed of at least two detecting plates (detector heads) with dimensions that are optimized for the breast, axilla region, brain and prostrate region or other extremities; motorized mechanical means to allow the movement of the plates under manual or computer control, making it possible to collect data in several orientations as needed for tomographic image reconstruction; an electronics system composed by a front-end electronics system, located physically on the detector heads, and a trigger and data acquisition system located off-detector in an electronic crate; a data acquisition and control software; and an image reconstruction and analysis software that allows reconstructing, visualizing and analyzing the data produced during the examination.Type: GrantFiled: September 30, 2005Date of Patent: March 29, 2011Assignees: FFCUL/BEB-Fundacao Da Faculdade De Ciencias Da Universidade De Lisboa, Instituto De Biofisica E Engenharia Biomedia, Universidade De Coimbra/Faculdade De Medicina-Instituto Biomedico De Investigaceo Da Luz E Imagem, Inesc Inovacao-Instituto De Novas Tecnologia (INOV), Inegi-Instituto De Engenharla Mecanica E Gestao Industrial, Tagusparque-Sociedade De Promocao E Desenvolvimento Do Parque De Ciencias E Tecnologia Da Area De Lisboa, S.A., Lip-Laboratorio de Instrumentacao e Fisica Experimental de Particulas, Hgo Hospital Garcia De Horta, Servicios De Medicina NuclearInventor: João Manuel Coelho Dos Santos Varela
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Patent number: 7799131Abstract: The present invention provides a method for the continuous production of semiconductor ribbons by growth from a linear molten zone. The creation of the molten zone is achieved by application of an electric current, direct or alternating, parallel to the surface of the ribbon and perpendicular to the direction of growth, and intense enough to melt the said material, preferably using electrodes of the said material. The molten zone is fed by transference of the material, in the liquid state, from one or more reservoirs, where melting of the feedstock occurs. Preferably, the said electrodes and the said reservoir(s) are only constituted by the said material, thus avoiding contamination by foreign materials. The present invention is applicable, for example, in the industry of silicon ribbons production for photovoltaic application.Type: GrantFiled: April 15, 2004Date of Patent: September 21, 2010Assignee: Faculdade de Ciencias Da Universidade de LisboaInventors: António Vallêra, João Serra, Jorge Maia Alves, Miguel Brito, Roberto Gamboa, João Henriques
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Patent number: 7622498Abstract: Pesticidal compounds of general formula (I) Wherein ?represents a double bond; A— represents ?C(R5)—C(?O)—, wherein R represents hydrogen or halogen, R1 and R2 represent, independently, hydrogen, halogen, alkoxy, substituted alkoxy or an ester group; or R1 and R2, together with the carbon atoms to which they are attached, represent an oxirane ring; or R1 and R2, taken together, represent an alkylidenedioxy or substituted alkylidenedioxy group; and R3 represents —CH2R6, wherein R6 represents an ester group, oxiranyl, or a group of formula wherein R7 represents hydrogen or alkyl, R8 represents phenylsulfanyl, phenylselenyl, phenylsulfoxy or phenylselenoxy, and R9 represents hydrogen, ethoxycarbonyl or carbamoyl and R4 represents, independently, hydrogen, alkoxy or substituted alkoxy; and methods of making the compounds of formula (I) and methods for controlling pests wherein the pest dies as a result of contact with a compound of formula (I).Type: GrantFiled: August 3, 2007Date of Patent: November 24, 2009Assignees: Instituto Politecnico de Santarem/Escoal Superior Agraria, Faculdade de Ciencias da Universidade de Lisboa, University of NewcastleInventors: Jorge Alberto Guerra Justino, Amelia Pilar Grases Santos Silva Rauter, Tana Lukeba Canda, Richard Wilkins
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Patent number: 7538139Abstract: A method for controlling pests, the method comprising applying an effective amount to pests or their locus of one or more compounds of general formula (I) wherein R1 and R2 represent, independently from each other, hydrogen, halogen, alkoxy, substituted alkoxy or an ester group; R1 and R2, together with the carbon atoms to which they are attached, represent an oxirane ring; R1 and R2, taken together, represent an akylidenedioxy or substituted alkylidenedioxy group; and R3 represents —CH2R6, wherein R6 represents an ester group, oxiranyl, or a group of formula wherein R7 represents hydrogen or alkyl, R8 represents phenylsulfanyl, phenylselenyl, phenylsulfoxy or phenylselenoxy, and R9 represents hydrogen, ethoxycarbonyl or carbamoyl; and R4 represents, independently, hydrogen, alkoxy or substituted alkoxy, or R1 and R4, taken together, represent an alkylidenedioxy or a substituted alkylidenedioxy group; wherein the pest dies as a result of contact with the compound.Type: GrantFiled: July 28, 2006Date of Patent: May 26, 2009Assignees: Instituto Politecnico De Santarem/Escola Superior Agraria, Faculdade de Ciencias da Universidade de Lisboa, University of NewcastleInventors: Jorge Alberto Guerra Justino, Amélia Pilar Grases Santos Silva Rauter, Tana Lukeba Canda, Richard Wilkins
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Publication number: 20080004339Abstract: Pesticidal compounds of general formula (I) Wherein ----- represents a double bond; ----A— represents ?C(R5)—C(?O)—, wherein R represents hydrogen or halogen, R1 and R2 represent, independently, hydrogen, halogen, alkoxy, substituted alkoxy or an ester group; or R1 and R2, together with the carbon atoms to which they are attached, represent an oxirane ring; or R1 and R2, taken together, represent an alkylidenedioxy or substituted alkylidenedioxy group; and R3 represents —CH2R6, wherein R6 represents an ester group, oxiranyl, or a group of formula wherein R7 represents hydrogen or alkyl, R8 represents phenylsulfanyl, phenylselenyl, phenylsulfoxy or phenylselenoxy, and R9 represents hydrogen, ethoxycarbonyl or carbamoyl and R4 represents, independently, hydrogen, alkoxy or substituted alkoxy; and methods of making the compounds of formula (I) and methods for controlling pests wherein the pest dies as a result of contact with a compound of formula (I).Type: ApplicationFiled: August 3, 2007Publication date: January 3, 2008Applicants: INSTITUTO POLITECNICO DE SANTAREM/ESCOLA SUPERIOR AGRARIA, FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA, UNIVERSITY OF NEWCASTLEInventors: Jorge Justino, Amelia Pilar Rauter, Tana Canda, Richard Wilkins
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Publication number: 20070241481Abstract: The present invention provides a method for the continuous production of semiconductor ribbons by growth from a linear molten zone. The creation of the molten zone is achieved by application of an electric current, direct or alternating, parallel to the surface of the ribbon and perpendicular to the direction of growth, and intense enough to melt the said material, preferably using electrodes of the said material. The molten zone is fed by transference of the material, in the liquid state, from one or more reservoirs, where melting of the feedstock occurs. Preferably, the said electrodes and the said reservoir(s) are only constituted by the said material, thus avoiding contamination by foreign materials. The present invention is applicable, for example, in the industry of silicon ribbons production for photovoltaic application.Type: ApplicationFiled: April 15, 2004Publication date: October 18, 2007Applicant: FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOAInventors: Antonio Vallera, Serra Joao, Jorge Maia Alves, Miguel Brito, Roberto Gamboa, Joao Henriques
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Publication number: 20070117865Abstract: A method for controlling pests, the method comprising applying an effective amount to pests or their locus of one or more compounds of general formula (I) wherein R1 and R2 represent, independently from each other, hydrogen, halogen, alkoxy, substituted alkoxy or an ester group; R1 and R2, together with the carbon atoms to which they are attached, represent an oxirane ring; R1 and R2, taken together, represent an akylidenedioxy or substituted alkylidenedioxy group; and R3 represents —CH2R6, wherein R6 represents an ester group, oxiranyl, or a group of formula wherein R7 represents hydrogen or alkyl, R8 represents phenylsulfanyl, phenylselenyl, phenylsulfoxy or phenylselenoxy, and R9 represents hydrogen, ethoxycarbonyl or carbamoyl; and R4 represents, independently, hydrogen, alkoxy or substituted alkoxy, or R1 and R4, taken together, represent an alkylidenedioxy or a substituted alkylidenedioxy group; wherein the pest dies as a result of contact with the compound.Type: ApplicationFiled: July 28, 2006Publication date: May 24, 2007Applicants: INSTITUTO POLITECNICO DE SANTAREM/ESCOLA SUPERIOR AGRARIA, FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA, UNIVERSITY OF NEWCASTLEInventors: Jorge Justino, Amelia Silva Rauter, Tana Canda, Richard Wilkins
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Publication number: 20060025613Abstract: The present invention relates to pesticidal compounds with general formula (I), their preparation and application to said pests or their locus, wherein represents C—C single or double bond; represents —CH(R4)—, if said C—C is a single bond, R4 hydrogen, alkoxy or substituted alkoxy, or R1, R4, taken together, form an alkylidenedioxy or substituted alkylidenedioxy group; or represents ?C(R5)—C(?O)—, if said C—C is a double bond, R5 hydrogen, halogen; R1, R2-hydrogen, halogen, alkoxy, substituted alkoxy or ester group, or R1, R2, taken together with the carbon atoms to which they are attached, represent an oxirane ring; or R1, R2, taken together, represent an alkylidenedioxy or substituted alkylidenedioxy group; R3 represents —CH2R6 (R6-ester group), oxiranyl, or a group of formula wherein R7 is hydrogen or alkyl, R8 phenylsulfanyl, phenylselenyl, phenylsulfoxy or phenylselenoxy; and R9 hydrogen, ethoxycarbonyl or carbamoyl.Type: ApplicationFiled: July 30, 2004Publication date: February 2, 2006Applicants: INSTITUTO POLITECNICO DE SANTAREM/ESCOLA SUPERIOR AGRARIA, FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA, UNIVERSITY OF NEWCASTLEInventors: Jorge Justino, Amelia Pilar Grases Santos Silva Rauter, Tana Canda, Richard Wilkins