Abstract: The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that bind to these modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.
Type:
Grant
Filed:
September 26, 2013
Date of Patent:
May 3, 2016
Assignees:
INSTITUT PASTEUR, INSTITUTO DE INVESTIGACIONES BIOLOGICAS CLEMENTE ESTABLE, FACULTAD DE MEDICINA, UNIVERSIDAD DE LA REPUBLICA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Inventors:
Luis Barbeito, Mariana Pehar, Patricia Cassina, Pedro M. Alzari
Abstract: The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.
Type:
Application
Filed:
September 26, 2013
Publication date:
June 26, 2014
Applicants:
INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, FACULTAD DE MEDICINA UNIVERSIDAD DE LA REPUBLICA, INSTITUTO DE INVESTIGACIONES SIOL. CLEM. ESTASLE
Inventors:
Luis BARBEITO, Mariana Pehar, Patricia Cassina, Pedro M. Alzari
Abstract: The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving a chronic pain and/or neuron loss.
Type:
Application
Filed:
July 23, 2007
Publication date:
March 4, 2010
Applicants:
Institut Pasteur, Instituto De Investigaciones Biol. Clem. Estable, Facultad De Medicina, Universidad De La Republica, Centre National De La Recherche Scientifique
Inventors:
Luis Barbeito, Mariana Pehar, Patricia Cassina, Pedro M. Alzari