Abstract: New 4-substituted piperidines of the following general formula (I) are disclosed in which R1 and R2 are substituted in unsubstituted aryl radicals, which compounds are obtained as racemic mixtures and as pure enantiomers. The compounds, and their pharmaceutically acceptable salts, inhibit the serotonin and/or noradrenaline reuptake, and are useful as medicaments in disorders in which an increase of levels of those neurotransmitters is necessary.

Abstract: A description is given of new arylpiperazinylalkyl-3(2H)-pyridazinones of general formula (I) and their preparation and their addition salts with pharmaceutically acceptable acids, in which R1 is a methyl or phenyl radical, R2 is a hydrogen atom or a methyl radical, n takes values between 2 and 4, and R3 is a naphthyl radical or a phenyl radical, which are substituted by a radical such as methoxyl, trifluoromethyl and chlorine. The compounds have affinity for serotonin 5HT1A and 5HT2 receptors and for dopamine D2 receptors, and can be useful as antipsychotics.