Patents Assigned to Farmabios S.p.A.
  • Patent number: 12247048
    Abstract: The present invention is directed to a process for the preparation of cortexolone 17?-propionate, comprising a hydrolysis reaction of an ortho-ester of formula (III) in which R is a hydrogen atom or a methyl group, in the presence of a dilute solution of acetic acid. The present invention is also directed to a hydrated crystalline form of cortexolone 17?-propionate obtained by such process.
    Type: Grant
    Filed: March 30, 2022
    Date of Patent: March 11, 2025
    Assignee: Farmabios S.P.A.
    Inventors: Ponzinibi Matteo, Roberto Arosio, Brusasca Marco, Di Giacomo Mario
  • Publication number: 20220259257
    Abstract: The present invention relates to a process for the preparation of Fulvestrant which includes recovering the by-products deriving from the oxidation of the corresponding sulfide and then subjecting the by-products to a reduction reaction in the presence of specific reducing agents.
    Type: Application
    Filed: February 4, 2022
    Publication date: August 18, 2022
    Applicant: FARMABIOS S.P.A.
    Inventors: ROBERTO AROSIO, MAURO GABOARDI, FRANCESCO ZERILLI
  • Publication number: 20220106352
    Abstract: A process for the preparation of fulvestrant 3-boronic acid and intermediates useful for the preparation of fulvestrant 3-boronic acid according to the process are described. Fulvestrant 3-boronic acid is obtained with high purity.
    Type: Application
    Filed: March 11, 2020
    Publication date: April 7, 2022
    Applicant: FARMABIOS S.P.A.
    Inventors: Mauro GABOARDI, Cristina MANFROTTO, Mario DI GIACOMO
  • Publication number: 20210188767
    Abstract: The present invention discloses a method for the purification of cysteamine or a salt thereof from polysulfuric impurities, in particular from cystamine, by treatment with dithiothreitol.
    Type: Application
    Filed: December 22, 2020
    Publication date: June 24, 2021
    Applicant: Farmabios S.p.A.
    Inventors: Roberto AROSIO, Francesco Zerilli, Mauro Gaboardi, Mario Di Giacomo
  • Patent number: 10711030
    Abstract: A method for the purification of allopregnanolone is disclosed. Allopregnanolone prepared from isopregnanolone contains impurities such as triphenylphosphine oxide and other unknown impurities. To remove these impurities and purify allopregnanolone, the allopregananolone is dissolved in acetonitrile, and crystallized from the acetonitrile. The resulting crystallized allopregnanolone may then be re-crystallized from acetonitrile to further purify the allopregnanolone.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: July 14, 2020
    Assignee: FARMABIOS S.P.S.
    Inventors: Enrico Torregrossa, Marco Brusasca, Cristina Manfrotto
  • Publication number: 20200087341
    Abstract: The present invention relates to a method for the preparation of allopregnanolone with a high degree of purity which, eventually, occurs through the formation of 3?-trifluoroacetoxy-5?-pregnan-20-one.
    Type: Application
    Filed: July 31, 2019
    Publication date: March 19, 2020
    Applicant: Farmabios S.p.A.
    Inventors: Enrico TORREGROSSA, Marco BRUSASCA, Cristina MANFROTTO
  • Patent number: 9663450
    Abstract: A method for the purification and preparation of melphalan that allows to obtain melphalan with purity higher than 99.5% is described.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: May 30, 2017
    Assignee: FARMABIOS S.P.A.
    Inventors: Claudio Gianluca Pozzoli, Valentina Canevari, Matteo Curti
  • Patent number: 9109000
    Abstract: A process for the preparation of nucleosides, derivatives and analogues thereof by coupling reaction of a protected suitable nitrogeneous purine or pyrimidine base, a derivative or analogue thereof and a protected suitable sugar in the presence of SnCl4 comprising the removal of SnCl4 by adding DMSO directly into the reaction mixture is described. Preferably said process is used for the preparation of antiviral and antitumor agents having a nucleoside or nucleoside-like structure, still more preferably for the preparation of azacytidine, decitabine, chlorfarabine, cladribine, mizoribine. A residual tin content lower than 300 ppm is obtained with said process.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: August 18, 2015
    Assignee: FARMABIOS, S.p.A.
    Inventors: Claudio Gianluca Pozzoli, Valentina Canevari, Marco Brusasca, Lorenzo Menna, Matteo Curti
  • Publication number: 20140135490
    Abstract: A process for the preparation of nucleosides, derivatives and analogues thereof by coupling reaction of a protected suitable nitrogeneous purine or pyrimidine base, a derivative or analogue thereof and a protected suitable sugar in the presence of SnCl4 comprising the removal of SnCl4 by adding DMSO directly into the reaction mixture is described. Preferably said process is used for the preparation of antiviral and antitumor agents having a nucleoside or nucleoside-like structure, still more preferably for the preparation of azacytidine, decitabine, chlorfarabine, cladribine, mizoribine. A residual tin content lower than 300 ppm is obtained with said process.
    Type: Application
    Filed: October 25, 2013
    Publication date: May 15, 2014
    Applicant: FARMABIOS S.p.A.
    Inventors: Claudio Gianluca POZZOLI, Valentina CANEVARI, Marco BRUSASCA, Lorenzo MENNA, Matteo CURTI
  • Patent number: 8158795
    Abstract: A process for the preparation of neuromuscular blocking agents with isoquinoline structure, such as atracurium besylate, doxacurium chloride, mivacurium chloride and gantacurium chloride, by chromatographic purification of their mixtures of isomers using a silica modified by treatment with a tertiary amine of formula NR1R2R3 or a corresponding quaternary ammonium compound N+R1R2R3R4X? wherein R1, R2, R3 and R4, the same or different, are linear or branched C1-C4 alkyl groups or —CH2—Ar groups or two among R1, R2, R3 and R4 form a 5- or 6-membered cycle, optionally substituted with a —CH2—Ar group or condensed with an Ar group, Ar being an aryl optionally substituted with one or more electrodonating groups, and X? being a suitable anion, is described.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: April 17, 2012
    Assignee: Farmabios S.p.A.
    Inventors: Claudio Gianluca Pozzoli, Franco Malanga, Vincenzo Redaelli
  • Patent number: 7872137
    Abstract: A process for preparing the [R—[R*,R*-(E)]]-2,2?-(1,8-dioxo-4-octene-1,8-diyl) bis(oxy-3,1-propanediyl)bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl) methyl]isoquinolinium) dichloride, commonly known as mivacurium chloride, useful as short-duration neuromuscular blocking agent.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: January 18, 2011
    Assignee: Farmabios S.p.A.
    Inventors: Maurizio Francesco Velati, Andrea Busca, Cristina Manfrotto, Marco Nicolini, Claudio Gianluca Pozzoli
  • Publication number: 20100331539
    Abstract: A stereoselective and enrichment process for the preparation of ciclesonide is described.
    Type: Application
    Filed: March 12, 2009
    Publication date: December 30, 2010
    Applicant: FARMABIOS S.P.A.
    Inventors: Filippo La Loggia, Matteo Curti, Claudio Gianluca Pozzoli
  • Publication number: 20100016596
    Abstract: A process for the preparation of neuromuscular blocking agents with isoquinoline structure, such as atracurium besylate, doxacurium chloride, mivacurium chloride and gantacurium chloride, by chromatographic purification of their mixtures of isomers using a silica modified by treatment with a tertiary amine of formula NR1R2R3 or a corresponding quaternary ammonium compound N+R1R2R3R4X? wherein R1, R2, R3 and R4, the same or different, are linear or branched C1-C4 alkyl groups or —CH2—Ar groups or two among R1, R2, R3 and R4 form a 5- or 6-membered cycle, optionally substituted with a —CH2—Ar group or condensed with an Ar group, Ar being an aryl optionally substituted with one or more electrodonating groups, and X? being a suitable anion, is described.
    Type: Application
    Filed: July 10, 2009
    Publication date: January 21, 2010
    Applicant: FARMABIOS S.P.A.
    Inventors: Claudio Gianluca POZZOLI, Franco MALANGA, Vincenzoi Redaelli