Patents Assigned to Farmabios S.p.A.
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Patent number: 12247048Abstract: The present invention is directed to a process for the preparation of cortexolone 17?-propionate, comprising a hydrolysis reaction of an ortho-ester of formula (III) in which R is a hydrogen atom or a methyl group, in the presence of a dilute solution of acetic acid. The present invention is also directed to a hydrated crystalline form of cortexolone 17?-propionate obtained by such process.Type: GrantFiled: March 30, 2022Date of Patent: March 11, 2025Assignee: Farmabios S.P.A.Inventors: Ponzinibi Matteo, Roberto Arosio, Brusasca Marco, Di Giacomo Mario
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Publication number: 20220259257Abstract: The present invention relates to a process for the preparation of Fulvestrant which includes recovering the by-products deriving from the oxidation of the corresponding sulfide and then subjecting the by-products to a reduction reaction in the presence of specific reducing agents.Type: ApplicationFiled: February 4, 2022Publication date: August 18, 2022Applicant: FARMABIOS S.P.A.Inventors: ROBERTO AROSIO, MAURO GABOARDI, FRANCESCO ZERILLI
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Publication number: 20220106352Abstract: A process for the preparation of fulvestrant 3-boronic acid and intermediates useful for the preparation of fulvestrant 3-boronic acid according to the process are described. Fulvestrant 3-boronic acid is obtained with high purity.Type: ApplicationFiled: March 11, 2020Publication date: April 7, 2022Applicant: FARMABIOS S.P.A.Inventors: Mauro GABOARDI, Cristina MANFROTTO, Mario DI GIACOMO
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Publication number: 20210188767Abstract: The present invention discloses a method for the purification of cysteamine or a salt thereof from polysulfuric impurities, in particular from cystamine, by treatment with dithiothreitol.Type: ApplicationFiled: December 22, 2020Publication date: June 24, 2021Applicant: Farmabios S.p.A.Inventors: Roberto AROSIO, Francesco Zerilli, Mauro Gaboardi, Mario Di Giacomo
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Patent number: 10711030Abstract: A method for the purification of allopregnanolone is disclosed. Allopregnanolone prepared from isopregnanolone contains impurities such as triphenylphosphine oxide and other unknown impurities. To remove these impurities and purify allopregnanolone, the allopregananolone is dissolved in acetonitrile, and crystallized from the acetonitrile. The resulting crystallized allopregnanolone may then be re-crystallized from acetonitrile to further purify the allopregnanolone.Type: GrantFiled: July 31, 2019Date of Patent: July 14, 2020Assignee: FARMABIOS S.P.S.Inventors: Enrico Torregrossa, Marco Brusasca, Cristina Manfrotto
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Publication number: 20200087341Abstract: The present invention relates to a method for the preparation of allopregnanolone with a high degree of purity which, eventually, occurs through the formation of 3?-trifluoroacetoxy-5?-pregnan-20-one.Type: ApplicationFiled: July 31, 2019Publication date: March 19, 2020Applicant: Farmabios S.p.A.Inventors: Enrico TORREGROSSA, Marco BRUSASCA, Cristina MANFROTTO
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Patent number: 9663450Abstract: A method for the purification and preparation of melphalan that allows to obtain melphalan with purity higher than 99.5% is described.Type: GrantFiled: May 27, 2014Date of Patent: May 30, 2017Assignee: FARMABIOS S.P.A.Inventors: Claudio Gianluca Pozzoli, Valentina Canevari, Matteo Curti
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Patent number: 9109000Abstract: A process for the preparation of nucleosides, derivatives and analogues thereof by coupling reaction of a protected suitable nitrogeneous purine or pyrimidine base, a derivative or analogue thereof and a protected suitable sugar in the presence of SnCl4 comprising the removal of SnCl4 by adding DMSO directly into the reaction mixture is described. Preferably said process is used for the preparation of antiviral and antitumor agents having a nucleoside or nucleoside-like structure, still more preferably for the preparation of azacytidine, decitabine, chlorfarabine, cladribine, mizoribine. A residual tin content lower than 300 ppm is obtained with said process.Type: GrantFiled: October 25, 2013Date of Patent: August 18, 2015Assignee: FARMABIOS, S.p.A.Inventors: Claudio Gianluca Pozzoli, Valentina Canevari, Marco Brusasca, Lorenzo Menna, Matteo Curti
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Publication number: 20140135490Abstract: A process for the preparation of nucleosides, derivatives and analogues thereof by coupling reaction of a protected suitable nitrogeneous purine or pyrimidine base, a derivative or analogue thereof and a protected suitable sugar in the presence of SnCl4 comprising the removal of SnCl4 by adding DMSO directly into the reaction mixture is described. Preferably said process is used for the preparation of antiviral and antitumor agents having a nucleoside or nucleoside-like structure, still more preferably for the preparation of azacytidine, decitabine, chlorfarabine, cladribine, mizoribine. A residual tin content lower than 300 ppm is obtained with said process.Type: ApplicationFiled: October 25, 2013Publication date: May 15, 2014Applicant: FARMABIOS S.p.A.Inventors: Claudio Gianluca POZZOLI, Valentina CANEVARI, Marco BRUSASCA, Lorenzo MENNA, Matteo CURTI
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Patent number: 8158795Abstract: A process for the preparation of neuromuscular blocking agents with isoquinoline structure, such as atracurium besylate, doxacurium chloride, mivacurium chloride and gantacurium chloride, by chromatographic purification of their mixtures of isomers using a silica modified by treatment with a tertiary amine of formula NR1R2R3 or a corresponding quaternary ammonium compound N+R1R2R3R4X? wherein R1, R2, R3 and R4, the same or different, are linear or branched C1-C4 alkyl groups or —CH2—Ar groups or two among R1, R2, R3 and R4 form a 5- or 6-membered cycle, optionally substituted with a —CH2—Ar group or condensed with an Ar group, Ar being an aryl optionally substituted with one or more electrodonating groups, and X? being a suitable anion, is described.Type: GrantFiled: July 10, 2009Date of Patent: April 17, 2012Assignee: Farmabios S.p.A.Inventors: Claudio Gianluca Pozzoli, Franco Malanga, Vincenzo Redaelli
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Patent number: 7872137Abstract: A process for preparing the [R—[R*,R*-(E)]]-2,2?-(1,8-dioxo-4-octene-1,8-diyl) bis(oxy-3,1-propanediyl)bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl) methyl]isoquinolinium) dichloride, commonly known as mivacurium chloride, useful as short-duration neuromuscular blocking agent.Type: GrantFiled: June 19, 2007Date of Patent: January 18, 2011Assignee: Farmabios S.p.A.Inventors: Maurizio Francesco Velati, Andrea Busca, Cristina Manfrotto, Marco Nicolini, Claudio Gianluca Pozzoli
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Publication number: 20100331539Abstract: A stereoselective and enrichment process for the preparation of ciclesonide is described.Type: ApplicationFiled: March 12, 2009Publication date: December 30, 2010Applicant: FARMABIOS S.P.A.Inventors: Filippo La Loggia, Matteo Curti, Claudio Gianluca Pozzoli
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Publication number: 20100016596Abstract: A process for the preparation of neuromuscular blocking agents with isoquinoline structure, such as atracurium besylate, doxacurium chloride, mivacurium chloride and gantacurium chloride, by chromatographic purification of their mixtures of isomers using a silica modified by treatment with a tertiary amine of formula NR1R2R3 or a corresponding quaternary ammonium compound N+R1R2R3R4X? wherein R1, R2, R3 and R4, the same or different, are linear or branched C1-C4 alkyl groups or —CH2—Ar groups or two among R1, R2, R3 and R4 form a 5- or 6-membered cycle, optionally substituted with a —CH2—Ar group or condensed with an Ar group, Ar being an aryl optionally substituted with one or more electrodonating groups, and X? being a suitable anion, is described.Type: ApplicationFiled: July 10, 2009Publication date: January 21, 2010Applicant: FARMABIOS S.P.A.Inventors: Claudio Gianluca POZZOLI, Franco MALANGA, Vincenzoi Redaelli