Abstract: A method for the purification of allopregnanolone is disclosed. Allopregnanolone prepared from isopregnanolone contains impurities such as triphenylphosphine oxide and other unknown impurities. To remove these impurities and purify allopregnanolone, the allopregananolone is dissolved in acetonitrile, and crystallized from the acetonitrile. The resulting crystallized allopregnanolone may then be re-crystallized from acetonitrile to further purify the allopregnanolone.
Type:
Grant
Filed:
July 31, 2019
Date of Patent:
July 14, 2020
Assignee:
FARMABIOS S.P.S.
Inventors:
Enrico Torregrossa, Marco Brusasca, Cristina Manfrotto