Abstract: A method, as well as a storage and manipulation system for manipulating and transferring cassettes used for storage, which system comprises a rack for storing cassettes, equipped with supports on which the cassette rests and along which the cassette is transferred, as well as a transfer device which is equipped with: a slide, onto which the cassette can be transferred and which can be transferred in the horizontal direction and which is provided with a lifting and lowering movement; and grippers with the function of gripping the cassette and moving it onto or off the slide. The slide is arranged to be placed underneath the front part of the cassette and, by means of a lifting movement, to elevate the front part of the cassette in such a way that the cassette can be transferred along the slide onto the slide, its rear part being simultaneously supported by the support of the rack.