Abstract: Disclosed herein, in certain embodiments, are vacuum-based systems, products, devices, and methods for de-odorizing, disinfecting, or cleaning articles such as clothing, shoes, toys, or dishes. A system or device can comprise a vacuum chamber comprising a housing defining an internal space having an internal pressure and an opening; a vacuum lid adapted to engage with the opening of the vacuum chamber; and a vacuum source connected to the vacuum chamber, wherein operation of the vacuum source reduces the internal pressure of the internal space of the vacuum chamber, wherein the lower internal pressure enhances the vaporization and removal of odors located on one or more articles disposed within the vacuum chamber.