Abstract: The present invention provides a method of differentiating and proliferating a mesenchymal stem cell into the neural cell by culturing in a medium comprising an epidermal growth factor and a hepatocyte growth factor after confluent culture of the mesenchymal stem cell. The present invention provides more effective method of differentiating and proliferating the mesenchymal stem cell or the mononuclear cell comprising the mesenchymal stem cell into the neural cell with a neuron and an astrocyte in terms of time, efficiency and maturity as compared with conventional methods.
Type:
Grant
Filed:
October 29, 2003
Date of Patent:
December 22, 2009
Assignees:
FCB Pharmicell Co., Ltd.
Inventors:
Hyun-Soo Kim, Young-Mo Kang, Kyung-Bock Lee, Sang-Kyo Park, Sang-Kap Lee
Abstract: Lymphoid dendritic cells with immunophenotype CD8?+ can be produced by a method which comprises culturing human hematopoietic stem cells in a medium containing GM-CSF, followed by culturing in a medium containing IFN-?, the lymphoid dendritic cells being useful in various immunotherapies.
Abstract: The present invention relates to an adenosine deaminase inhibitor and a novel Bacillus sp. strain which produces it. Particularly, the present 5 invention relates to the adenosine deaminase inhibitor, and the novel Bacillus sp. IADA-7 producing the above adenosine deaminase inhibitor. The adenosine deaminase inhibitor of the present Invention shows superior antibacterial and anticancer activities to the previously reported adenosine deaminase inhibitors.
Type:
Grant
Filed:
March 24, 2004
Date of Patent:
June 24, 2008
Assignee:
FCB-Pharmicell Co., Ltd.
Inventors:
Gwang Lee, Young Hwan Ahn, Ki Ho Park, Hong Ki Jun
Abstract: A method for differentiating mesenchymal stem cells of bone marrow into neural cells comprises culturing the mesenchymal stem cells in a medium containing epidermal growth factor(EGF), basic fibroblast growth factor(bFGF) and hepatocyte growth factor(HGF), and the neural cells produced thereby can be employed for the treatment of a neural disease.
Type:
Grant
Filed:
April 19, 2002
Date of Patent:
June 12, 2007
Assignees:
FCB-Pharmicell Co., Ltd., LifeCord International Co., Ltd.