Patents Assigned to Febit Holding GmbH
  • Publication number: 20140024554
    Abstract: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject.
    Type: Application
    Filed: December 28, 2011
    Publication date: January 23, 2014
    Applicant: febit Holding GmbH
    Inventors: Andreas Keller, Markus Beier
  • Publication number: 20130331278
    Abstract: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject.
    Type: Application
    Filed: December 28, 2011
    Publication date: December 12, 2013
    Applicant: febit Holding GmbH
    Inventors: Andreas Keller, Markus Beier, Valesca Boisguerin, Eckart Meese, Petra Leidinger
  • Publication number: 20130331290
    Abstract: The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of a lung disease in a biological sample from a patient. Further, the present invention relates to means for diagnosing and/or prognosing of a lung disease comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of a lung disease based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for a lung disease. In addition, the present invention relates to a kit for diagnosing and/or prognosing of a lung disease comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for a lung disease and optionally at least one reference and/or algorithm or mathematical function comprised on at least one data carrier.
    Type: Application
    Filed: January 26, 2012
    Publication date: December 12, 2013
    Applicant: febit Holding GmbH
    Inventors: Andreas Keller, Markus Beier
  • Publication number: 20130035251
    Abstract: MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.
    Type: Application
    Filed: December 30, 2010
    Publication date: February 7, 2013
    Applicant: febit holding GmbH
    Inventors: Andreas Keller, Eckart Meese, Anne Borries, Markus Beier
  • Patent number: 8173368
    Abstract: The invention relates to methods and devices for preparing synthetic nucleic acids.
    Type: Grant
    Filed: August 23, 2007
    Date of Patent: May 8, 2012
    Assignee: febit holding GmbH
    Inventors: Peer Staehler, Raphael Carapito
  • Patent number: 7901886
    Abstract: The invention relates to an extraction method for isolating target molecules from a sample using a microfluidic carrier.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: March 8, 2011
    Assignee: Febit Holding GmbH
    Inventors: Cord F. Staehler, Peer F. Staehler, Manfred Mueller
  • Patent number: 7790369
    Abstract: The invention relates to a method for producing polymers, in particular synthetic nucleic acid double strands of optional sequence, comprising the steps: (a) providing a support having a surface area which contains a plurality of individual reaction areas, (b) location-resolved synthesizing nucleic acid fragments each having different base sequences in several of the individual reaction areas, and (c) detaching the nucleic acid fragments from individual reaction areas.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: September 7, 2010
    Assignee: febit holding GmbH
    Inventors: Peer F. Stähler, Cord F. Stähler, Manfred Müller
  • Patent number: 7737088
    Abstract: The present invention relates to arrays of biochemical and/or biofunctional elements such as nucleic acids (oligonucleotides, for example) or other biomolecules on a carrier surface and methods of producing such arrays using photoactivation of predetermined areas for synthesis using an illumination matrix that is computer-controlled to generate an exposure pattern. This exposure pattern can be adjusted and monitored by computer using a light sensor matrix, for example a CCD matrix, to allow precise, controlled illumination of specific regions and therefore attachment of array building blocks to those specific regions. The methods and compositions of the invention permit spatially resolved photochemical synthesis of polymer probes on a carrier.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: June 15, 2010
    Assignee: Febit Holding GmbH
    Inventors: Cord F. Stähler, Peer F. Stähler, Manfred Müller, Fritz Stähler, Hans Lindner
  • Patent number: 7737089
    Abstract: The present invention relates to a process for synthesizing biopolymers by stepwise assembly from protected synthesis building blocks which carry two-stage protective groups. The two-stage protective groups are activated by a first illumination step and eliminated by a subsequent chemical treatment step. Photoactivatable components which considerably speed up the activation process via intramolecular triplet sensitizers or/and have fluorescence properties are used. The two-stage protective groups can be used in particular within the framework of quality control.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: June 15, 2010
    Assignee: Febit Holding GmbH
    Inventors: Ramon Güimil, Matthias Scheffler, Barbro Beijer
  • Publication number: 20090170802
    Abstract: The invention relates to a method for producing polymers, in particular synthetic nucleic acid double strands of optional sequence, comprising the steps: (a) provision of a support having a surface area which contains a plurality of individual reaction areas, (b) location-resolved synthesis of nucleic acid fragments having in each case different base sequences in several of the individual reaction areas, and (c) detachment of the nucleic acid fragments from individual reaction areas.
    Type: Application
    Filed: March 9, 2009
    Publication date: July 2, 2009
    Applicant: Febit Holding GmbH
    Inventors: Peer F. Stahler, Cord F. Stahler, Manfred Muller