Patents Assigned to Feed Research Institute Chinese Academy of Agricultural Sciences
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Patent number: 11827677Abstract: The present invention provides an antimicrobial peptide ID13 (with a sequence set forth in SEQ ID NO. 1), a preparation method and use thereof. The antimicrobial peptide ID3 is successfully expressed in Pichia pastoris using genetic engineering technology. The antimicrobial peptide ID13 of the present invention has an excellent bactericidal activity against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus suis, and has a low hemolytic activity against mouse red blood cells and a low murine macrophage cytotoxicity.Type: GrantFiled: October 23, 2020Date of Patent: November 28, 2023Assignee: Feed Research Institute, Chinese Academy of Agricultural SciencesInventors: Jianhua Wang, Bing Li, Da Teng, Ruoyu Mao, Xiumin Wang, Ya Hao, Na Yang
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Publication number: 20210171585Abstract: The present invention provides an antimicrobial peptide ID13 (with a sequence set forth in SEQ ID No. 1), a preparation method and use thereof. The antimicrobial peptide ID3 is successfully expressed in Pichia pastoris using genetic engineering technology. The antimicrobial peptide ID13 of the present invention has an excellent bactericidal activity against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus suis, and has a low hemolytic activity against mouse red blood cells and a low murine macrophage cytotoxicity.Type: ApplicationFiled: October 23, 2020Publication date: June 10, 2021Applicant: Feed Research Institute, Chinese Academy of Agricultural SciencesInventors: Jianhua WANG, Bing LI, Da TENG, Ruoyu MAO, Xiumin WANG, Ya HAO, Na YANG
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Patent number: 10920206Abstract: Provided are acidic thermophilic polygalacturonase TePG28A, encoding gene and application thereof. The amino acid sequence thereof is as shown in SEQ ID NO. 1 or SEQ ID NO. 2. The expressed acidic thermophilic polygalacturonase by means of cloning has advantages such as high enzyme activity and high stability; can adapt to the high temperature environment in the industrial production; has better application prospect; and can effectively degrade pectic substances such as polygalacturonic acid and pectin; and can be effectively applied to the industrial field of feed, food, and textile, etc.Type: GrantFiled: December 15, 2016Date of Patent: February 16, 2021Assignee: FEED RESEARCH INSTITUTE, CHINESE ACADEMY OF Agricultural SciencesInventors: Bin Yao, Huiying Luo, Yeqing Li, Yuan Wang, Tao Tu, Huoqing Huang, Yingguo Bai, Yaru Wang, Xiaoyun Su
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Patent number: 10920200Abstract: Provided are a glucose oxidase CnGODA, an encoding gene thereof, a recombinant expression vector comprising the gene, and a recombinant strain; the amino acid sequence of the glucose oxidase CnGODA is as represented in SEQ ID NO:1 or SEQ ID NO:2. Further provided is a method for use in preparing glucose oxidase CnGODA, and application of glucose oxidase CnGODA.Type: GrantFiled: June 7, 2018Date of Patent: February 16, 2021Assignee: FEED RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCESInventors: Bin Yao, Huiying Luo, Weina Liu, Jianzhong Ge, Tao Tu, Huoqing Huang, Xiaoyun Su, Yingguo Bai, Yuan Wang, Yaru Wang, Kun Meng
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Patent number: 10767170Abstract: Provided are a fungus-sourced high-temperature neutral Family-45 cullulase as well as a coding gene and application thereof. The cullulase has optimal pH value of 5.5, and optimal temperature of 60° C., has certain enzyme activity in alkaline condition, and has good alkali resistance, maintains about 70% enzyme activity in optimal condition after being processed at 90° C. for 1 hour, maintains about 50% enzyme activity in optimal condition after being processed in boiling water for 1 hour, and can be well applied in c and other fields.Type: GrantFiled: December 9, 2014Date of Patent: September 8, 2020Assignee: FEED RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCESInventors: Bin Yao, Pengjun Shi, Hong Yang, Huoqing Huang, Huiying Luo, Peilong Yang, Yaru Wang, Xiaoyun Su, Yingguo Bai, Xia Shi, Rui Ma, Kun Meng
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Publication number: 20200190484Abstract: Provided are a glucose oxidase CnGODA, an encoding gene thereof, a recombinant expression vector comprising the gene, and a recombinant strain; the amino acid sequence of the glucose oxidase CnGODA is as represented in SEQ ID NO.1 or SEQ ID NO.2. Further provided is a method for use in preparing glucose oxidase CnGODA, and application of glucose oxidase CnGODA.Type: ApplicationFiled: June 7, 2018Publication date: June 18, 2020Applicant: FEED RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCESInventors: Bin YAO, Huiying LUO, Weina LIU, Jianzhong GE, Tao TU, Huoqing HUANG, Xiaoyun SU, Yingguo BAI, Yuan WANG, Yaru WANG, Kun MENG
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Patent number: 9765313Abstract: The present invention relates to the field of genetic engineering, in particular, the present invention relates to a method for producing a phytase variant with an improved thermal stability, and a phytase variant and the use thereof. The phytase variant contains at least one proline modification, compared to the phytase from Escherichia coli and other mutants thereof. The phytase variants with the modification have preferably improved properties, such as the thermal stability, optimal reaction temperature, pH property, specific activity, protease resistance and performance in animal feeds.Type: GrantFiled: November 12, 2013Date of Patent: September 19, 2017Assignee: Feed Research Institute, Chinese Academy of Agricultural SciencesInventors: Bin Yao, Huoqing Huang, Huiying Luo, Chao Shao, Yingguo Bai, Yaru Wang, Peilong Yang, Pengjun Shi, Kun Meng, Heng Zhao, Rui Ma
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Patent number: 8455620Abstract: The present invention relates to a novel phytase enzyme, a novel isolated nucleic acid molecule coding the enzyme, and a novel Yersinia intermedia having phytase activity. Particularly, the present invention relates to the phytase having (a) Theoretical molecular weight 45.5 kDa, (b) high specific activity 3960±248 U/mg, (c) high stability at high temperature and wide pH, (d) optimal pH of 4.0-5.0, (e) optimal temperature of 50-60° C., (f) high resistance to pepsin and trypsin. The phytase is very suitable to be used in feed of monogastrics as feed additive. The present invention also relates to a recombinant vector comprising said nucleic acid molecule, a recombinant host cell (e.g., Pichia pastoris) harboring said recombinant vector, and a method for producing phytase using the recombinant host cell. The present invention further provides a feed additive comprising said phytase and/or host cells expressing a phytase as effective ingredient.Type: GrantFiled: April 30, 2006Date of Patent: June 4, 2013Assignee: Feed Research Institute Chinese Academy of Agricultural SciencesInventors: Bin Yao, Huiying Luo, Huoqing Huang, Yaru Wang, Tiezheng Yuan, Xiuyun Shi, Yingguo Bai, Kun Meng, Peilong Yang