Patents Assigned to Feinstein Institute for Medical Research, The
  • Nerve stimulation for treatment of diseases and disorders
    Patent number: 10507327
    Abstract: Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: December 17, 2019
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Kevin J. Tracey, Sangeeta S. Chavan
  • IGURATIMOD AS AN MIF INHIBITOR
    Publication number: 20190262307
    Abstract: Methods of treatment of MIF-related diseases and methods of MIF inhibition are provided.
    Type: Application
    Filed: November 8, 2017
    Publication date: August 29, 2019
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Yousef Al-Abed, Joshua Bloom, Mohamed Ahmed
  • ACTIVATION OF TRPA1+ NOCICEPTORS IN THE VAGUS NERVE ATTENUATES SYSTEMIC INFLAMMATION
    Publication number: 20190255175
    Abstract: Methods are disclosed for treating inflammation and sepsis and for promoting thermoregulation by activating neurons expressing TRPA1 in the vagus nerve.
    Type: Application
    Filed: February 13, 2019
    Publication date: August 22, 2019
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Sangeeta S. Chavan, Harold A. Silverman
  • TREATMENT OF INFLAMMATION BY SELECTIVE DMV CHOLINERGIC NEURON STIMULATION
    Publication number: 20190247659
    Abstract: Methods for electrical modulation of inflammation or serum TNF levels in a subject.
    Type: Application
    Filed: February 11, 2019
    Publication date: August 15, 2019
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Adam M. Kressel, Valentin A. Pavlov, Sangeeta S. Chavan, Kevin J. Tracey
  • Detection of aortic coarctation using photoplethysmography
    Patent number: 10376154
    Abstract: Methods and systems are described for detecting the likelihood of an aortic coarctation in an infant using photoplethysmographic pulse signals obtained from the hand and foot of the infant.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: August 13, 2019
    Assignees: The Feinstein Institute for Medical Research, Jerusalem College of Technology
    Inventors: Robert Koppel, Meir Nitzan
  • METHODS OF TREATING HYPERTENSION
    Publication number: 20190201499
    Abstract: Provided are CD4+ T-cell-based compositions and methods for treating hypertension.
    Type: Application
    Filed: September 8, 2017
    Publication date: July 4, 2019
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: William Hanes, Kevin Tracey, Peder Olofsson
  • C1q AND HMGB1 FUSION PROTEINS AND USES THEREOF
    Publication number: 20190169232
    Abstract: Fusion proteins of C1q peptides and HMBG1 A-box or HMBG1 B-box, or C1q peptides and DWESY peptide are provided, and methods of use thereof.
    Type: Application
    Filed: January 31, 2019
    Publication date: June 6, 2019
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventor: Betty A. Diamond
  • Treatment of radiation injury using ghrelin
    Patent number: 10265383
    Abstract: Methods are disclosed for mitigating radiation injury to a subject by administration of ghrelin.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: April 23, 2019
    Assignee: The Feinstein Institute For Medical Research
    Inventors: Ping Wang, Weng-Lang Yang
  • SMARTBOX AND USES THEREOF
    Publication number: 20190111434
    Abstract: Systems, devices and methods are disclosed for collecting laboratory specimens from laboratory specimen boxes once a specimen has been placed inside a box.
    Type: Application
    Filed: October 15, 2018
    Publication date: April 18, 2019
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Mike Eller, Ross Schneidman, Chris Zavala, Brian Torpey
  • Fastener
    Patent number: 10238440
    Abstract: A fastener includes an elongate fastener body defining a longitudinal axis substantially central thereto. The fastener body has a continuous outer fastener shell laterally surrounding the longitudinal axis. The fastener shell longitudinally separates a fastener head end and a fastener tip end. A tool-engaging feature is provided on the fastener head end. A plurality of teeth are located on the fastener shell and extend substantially laterally outward from the longitudinally axis. The fastener shell is comprised of at least one undulate face and at least one substantially flat face. The plurality of teeth are located only on the undulate faces. Each tooth is longitudinally separated from adjacent teeth along an undulate face. A method of installing the fastener into a receiving structure is also described.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: March 26, 2019
    Assignees: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE GENERAL HOSPITAL CORPORATION DBA MASSACHUSETTS GENERAL HOSPITAL
    Inventors: Stanley E Asnis, Peter D Asnis
  • LYMPHATIC SYSTEM NEUROMODULATION AND USES THEREOF
    Publication number: 20190038898
    Abstract: Methods are disclosed for preventing systemic infection or controlling metastases or providing a vaccine adjuvant in a subject, the methods comprising stimulating one or more peripheral nerves innervating one or more lymph nodes of the subject.
    Type: Application
    Filed: February 8, 2017
    Publication date: February 7, 2019
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Sangeeta S. Chavan, William M. Hanes, Kevin J. Tracey
  • INHIBITION OF AUTISM SPECTRUM DISORDER USING DECOY ANTIGENS TO MATERNAL BRAIN-REACTIVE ANTIBODIES
    Publication number: 20190040121
    Abstract: Methods of diagnosis and methods of treatment and prevention for autism spectrum disorder are provided using decoy antigens to maternal brain-reactive antibodies.
    Type: Application
    Filed: September 30, 2016
    Publication date: February 7, 2019
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Betty A. Diamond, Simone Mader, Lior Brimberg
  • USE OF DERMCIDIN IN STERILE INFLAMMATORY CONDITIONS
    Publication number: 20190030124
    Abstract: A method of treating a sterile inflammatory condition in a subject using an isolated dermcidin peptide or an active fragment thereof of or an active analog thereof is provided. Also provided is a method of inhibiting organ transplantation-associated is chemia/reperfusion and/or organ transplantation-associated inflammation.
    Type: Application
    Filed: October 21, 2016
    Publication date: January 31, 2019
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Ping Wang, Haichao Wang
  • SAA-domain-specific antibodies and peptide antagonists and use thereof to treat inflammatory diseases
    Patent number: 10183971
    Abstract: Isolated SAA peptides, fusion proteins and compositions comprising such are provided as are domain-specific SAA antibodies. Methods of treating sepsis and endotoxemia are also provided.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: January 22, 2019
    Assignee: The Feinstein Institute For Medical Research
    Inventors: Haichao Wang, Andrew E. Sama, Wei Li, Kevin J. Tracey
  • HEMICHANNEL EXTRACELLULAR-DOMAIN SPECIFIC AGENTS FOR TREATING SEPSIS
    Publication number: 20190008921
    Abstract: Methods of treating sepsis or endotoxemia in a subject comprising administering to the subject an amount of an antagonist of a Panx1 hemichannel protein or an amount of an antagonist of a Cx43 hemichannel protein.
    Type: Application
    Filed: August 3, 2016
    Publication date: January 10, 2019
    Applicant: The Feinstein Institute For Medical Research
    Inventors: Haichao Wang, Wei Li, Kevin J. Tracey, Ping Wang
  • Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
    Patent number: 10166395
    Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: January 1, 2019
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Kevin J. Tracey, Jared M. Huston
  • HAPTOGLOBIN DERIVATIVE FOR TREATMENT OF SEPSIS AND ACETAMINOPHEN-INDUCED LIVER DAMAGE
    Publication number: 20180344808
    Abstract: Methods for treating sepsis of acetaminophen-induced liver damage in a subject sing a haptoglobin derivative are provided. Compositions containing a haptoglobin derivative for treating sepsis of acetaminophen-induced liver damage are provided.
    Type: Application
    Filed: May 29, 2018
    Publication date: December 6, 2018
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Huan Yang
  • Treatment of solid tumors by inhibiting MRK/ZAK
    Patent number: 10144723
    Abstract: Methods and compounds are described for treating solid tumors, and in particular, malignant, neoplastic solid tumors such as glioblastoma and medulloblastoma, by inhibiting protein kinase MRK/ZAK activity. Also provided are pharmaceutical composition containing a MRK/ZAK inhibitor compound and a pharmaceutically acceptable carrier and a method of sensitizing tumor cells to radiation therapy comprising administering an effective amount of the MRK/ZAK inhibitor compound.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: December 4, 2018
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Rosamaria Ruggieri, Yousef Al-Abed, Marc Symons
  • Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
    Patent number: 9987492
    Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: June 5, 2018
    Assignee: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Jared M. Huston
  • Peptides inhibiting cold-inducible RNA binding protein activity
    Patent number: 9957295
    Abstract: Disclosed are pharmaceutical compositions comprising a CIRP inhibitor. Methods of treating a subject suffering from an inflammatory condition comprising administering to said subject a CIRP inhibitor are also described herein.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: May 1, 2018
    Assignee: The Feinstein Institute for Medical Research
    Inventor: Ping Wang