Patents Assigned to Feinstein Institute for Medical Research
  • SAA-domain-specific antibodies and peptide antagonists and use thereof to treat inflammatory diseases
    Patent number: 10183971
    Abstract: Isolated SAA peptides, fusion proteins and compositions comprising such are provided as are domain-specific SAA antibodies. Methods of treating sepsis and endotoxemia are also provided.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: January 22, 2019
    Assignee: The Feinstein Institute For Medical Research
    Inventors: Haichao Wang, Andrew E. Sama, Wei Li, Kevin J. Tracey
  • HEMICHANNEL EXTRACELLULAR-DOMAIN SPECIFIC AGENTS FOR TREATING SEPSIS
    Publication number: 20190008921
    Abstract: Methods of treating sepsis or endotoxemia in a subject comprising administering to the subject an amount of an antagonist of a Panx1 hemichannel protein or an amount of an antagonist of a Cx43 hemichannel protein.
    Type: Application
    Filed: August 3, 2016
    Publication date: January 10, 2019
    Applicant: The Feinstein Institute For Medical Research
    Inventors: Haichao Wang, Wei Li, Kevin J. Tracey, Ping Wang
  • Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
    Patent number: 10166395
    Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: January 1, 2019
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Kevin J. Tracey, Jared M. Huston
  • HAPTOGLOBIN DERIVATIVE FOR TREATMENT OF SEPSIS AND ACETAMINOPHEN-INDUCED LIVER DAMAGE
    Publication number: 20180344808
    Abstract: Methods for treating sepsis of acetaminophen-induced liver damage in a subject sing a haptoglobin derivative are provided. Compositions containing a haptoglobin derivative for treating sepsis of acetaminophen-induced liver damage are provided.
    Type: Application
    Filed: May 29, 2018
    Publication date: December 6, 2018
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Huan Yang
  • Treatment of solid tumors by inhibiting MRK/ZAK
    Patent number: 10144723
    Abstract: Methods and compounds are described for treating solid tumors, and in particular, malignant, neoplastic solid tumors such as glioblastoma and medulloblastoma, by inhibiting protein kinase MRK/ZAK activity. Also provided are pharmaceutical composition containing a MRK/ZAK inhibitor compound and a pharmaceutically acceptable carrier and a method of sensitizing tumor cells to radiation therapy comprising administering an effective amount of the MRK/ZAK inhibitor compound.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: December 4, 2018
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Rosamaria Ruggieri, Yousef Al-Abed, Marc Symons
  • Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
    Patent number: 9987492
    Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: June 5, 2018
    Assignee: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Jared M. Huston
  • Peptides inhibiting cold-inducible RNA binding protein activity
    Patent number: 9957295
    Abstract: Disclosed are pharmaceutical compositions comprising a CIRP inhibitor. Methods of treating a subject suffering from an inflammatory condition comprising administering to said subject a CIRP inhibitor are also described herein.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: May 1, 2018
    Assignee: The Feinstein Institute for Medical Research
    Inventor: Ping Wang
  • INHIBITORS OF ABETA AND SYNUCLEIN AGGREGATION
    Publication number: 20180098950
    Abstract: Provided are methods of inhibiting aggregation of amyloid-beta (A?) or accumulation of aggregated A? using certain guanylhydrazone compounds. Also provided are methods of treating or preventing an amyloid-related disease in a mammal, methods of treating a subject having Alzheimer's disease, methods of treating a subject at risk for Alzheimer's disease, methods of inhibiting aggregation or accumulation of a synuclein, methods of treating a subject having a disease at least partially mediated by synuclein, methods of treating a subject at risk for a disease at least partially mediated by synuclein, and methods of inhibiting aggregation or accumulation of a protein involved in a conformational disease, using the guanylhydrazone compounds.
    Type: Application
    Filed: December 12, 2017
    Publication date: April 12, 2018
    Applicant: The Feinstein Institute For Medical Research
    Inventor: Yousef Al-Abed
  • NERVE STIMULATION FOR TREATMENT OF DISEASES AND DISORDERS
    Publication number: 20180021580
    Abstract: Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.
    Type: Application
    Filed: August 15, 2017
    Publication date: January 25, 2018
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Sangeeta S. Chavan
  • BIOELECTRONIC PHARMACEUTICALS
    Publication number: 20180021214
    Abstract: Methods are disclosed for treating a subject having a disease or disorder comprising providing the subject with an acoustic energy stimulus derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.
    Type: Application
    Filed: August 15, 2017
    Publication date: January 25, 2018
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Sangeeta S. Chavan
  • DETECTION OF PATENT DUCTUS ARTERIOSUS USING PHOTOPLETHYSMOGRAPHY
    Publication number: 20170273581
    Abstract: Methods and systems are described for detecting the likelihood of patent ductus arteriosus (PDA) in an infant using electrocardiogram and photoplethysmographic pulse signals obtained from the upper body and foot of the infant.
    Type: Application
    Filed: August 27, 2015
    Publication date: September 28, 2017
    Applicants: The Feinstein Institute For Medical Research, Jerusalem College of Technolog
    Inventors: Robert Koppel, Robert Koppel
  • TREATMENT OF RADIATION INJURY USING GHRELIN
    Publication number: 20170274049
    Abstract: Methods are disclosed for mitigating radiation injury to a subject by administration of ghrelin.
    Type: Application
    Filed: September 8, 2015
    Publication date: September 28, 2017
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Ping Wang, Weng-Lang Yang
  • C1q peptides and uses thereof
    Patent number: 9758557
    Abstract: Isolated C1q peptides, fusion proteins and compositions comprising such and fusion proteins comprising are provided. Isolated fusion proteins comprising X4WX5YX6 as defined herein and compositions comprising such are also provided. Methods of treating autoimmune disorders are provided.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: September 12, 2017
    Assignee: The Feinstein Institute for Medical Research
    Inventor: Betty A. Diamond
  • Methods and compositions for diagnosis and treatment of B cell chronic lymphocytic leukemia
    Patent number: 9745364
    Abstract: This invention provides an anti-idiotype antibody that binds to the antigen-binding region of an antibody encoded by antibody genes selected from the group consisting of Set I, Set II, Set III, Set IV, Set V, Set VIa, Set VIb, Set VIc, Set VId, Set VIe, Set VII, and Set VIII, hybridomas and methods of treatments using such.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: August 29, 2017
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Bradley T. Messmer, Nicholas Chiorazzi, Emilia Albesiano
  • TREATMENT OF SOLID TUMORS BY INHIBITING MRK/ZAK
    Publication number: 20170217929
    Abstract: Methods and compounds are described for treating solid tumors, and in particular, malignant, neoplastic solid tumors such as glioblastoma and medulloblastoma, by inhibiting protein kinase MRK/ZAK activity. Also provided are pharmaceutical composition containg a MRK/ZAK inhibitor compound and a pharmaceutically acceptable carrier and a method of sensitizing tumor cells to radiation therapy comprising administering an effective amount of the MRK/ZAK inhibitor compound.
    Type: Application
    Filed: April 21, 2015
    Publication date: August 3, 2017
    Applicant: The Feinstein Institute For Medical Research
    Inventors: Rosamaria Ruggieri, Yousef Al-Abed, Marc Symons
  • CD38 as a prognostic indicator in B cell chronic lymphocytic leukemia
    Patent number: 9683265
    Abstract: The subject invention discloses a method for determining the prognosis and probable clinical course of a subject diagnosed with B-CLL. Specifically, the invention involves comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein an elevated level of CD38 expression in relation to the baseline level of CD38 expression may indicate poor prognosis or aggressive course of disease in the subject. Also disclosed is a method for determining whether the Ig V genes of the B-CLL cells of a B-CLL patient are mutated, comprising comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein a lower level of CD38 expression in relation to the baseline level indicates IG V gene mutation.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: June 20, 2017
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Nicholas Chiorazzi, Rajendra N. Damle, Tarun Wasil
  • DETECTION OF AORTIC COARCTATION USING PHOTOPLETHYSMOGRAPHY
    Publication number: 20170164842
    Abstract: Methods and systems are described for detecting the likelihood of an aortic coarctation in an infant using photoplethysmographic pulse signals obtained from the hand and foot of the infant.
    Type: Application
    Filed: March 12, 2015
    Publication date: June 15, 2017
    Applicants: The Feinstein Institute For Medical Research, Jerusalem College of Technology
    Inventors: Robert Koppel, Meir Nitzan
  • Treatment and prevention of radiation injury using MFG-E8
    Patent number: 9669070
    Abstract: Methods and compositions are disclosed for treating and preventing radiation injury using milk fat globule epidermal growth factor-factor VIII (MFG-E8).
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: June 6, 2017
    Assignee: The Feinstein Institute For Medical Research
    Inventor: Ping Wang
  • Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
    Patent number: 9662490
    Abstract: Described herein are devices, systems and method of treating inflammation by vagus nerve stimulation and the delivery of an anti-inflammatory drug. In particular, described herein are methods of treating inflammation including the steps of stimulating a subject's inflammatory reflex to inhibit the immune response and administering an anti-inflammatory drug.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: May 30, 2017
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Kevin J. Tracey, Mauricio Rosas-Ballina, Michael A. Faltys, Ralph J. Zitnik
  • Privacy curtain assembly with cleanable panels
    Patent number: 9661947
    Abstract: A privacy curtain assembly includes a main curtain portion. The main curtain portion includes a first side, a second side, and oppositely disposed leading edges located between the first and second sides. The privacy curtain assembly also includes at least one cleanable, wipable panel that is permanently affixed to one of the leading edges of the main curtain portion. The at least one panel is configured to be cleaned while permanently affixed to the main curtain portion.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: May 30, 2017
    Assignee: The Feinstein Institute for Medical Research
    Inventor: Lorenz W. Mayer