Abstract: A disposable unit-dose jet injection syringe having a cylindrically shaped syringe body. The syringe body has a rear open end and a forward closed end. The rear open end has an enlarged diameter forming a flange that retains the syringe to the driving system during the injection cycle. The closed end has an small area coined by a stamping process. A jet orifice is punched through the small area of the closed end. A cavity formed in syringe body is configured to hold a unit dose of liquid, drug, or biological. A piston is slidably engaged within the body to inject the unit dose. A driving system activates the piston to inject the unit dose out of the jet orifice. A method of manufacturing a jet injection syringe is also provided. A method of injecting a medicine is also provided.