Patents Assigned to Femalon S.A.
  • Patent number: 10180438
    Abstract: A method is described to obtain a class of embryos having a higher implantation potential than from morphology selection alone by selecting from a plurality of embryos, obtained by fertilizing the plurality of oocytes, a class of embryos having a high implantation potential. The selection is determined from a level of granulocyte-colony stimulating factor (G-CSF) present in the follicular fluid (FF) of each oocyte in the plurality of oocytes.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: January 15, 2019
    Assignee: FEMALON S.P.R.L.
    Inventors: Nathalie Ledee, Marie-Pierre Piccinni
  • Patent number: 9664692
    Abstract: A kit for determining for a female subject the implantation potential of embryos obtained or to be obtained by assisted fertilization is described. The kit includes at least one reagent suitable for detection of levels of FF G-CSF or FF G-CSF mRNA, such as anti-G-CSF antibody or a nucleic acid probe for detection of levels of G-CSF mRNA. The kit may also include a set of concentration standards of FF G-CSF and aspirator tips for removing an oocyte and follicular fluid.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: May 30, 2017
    Assignee: FEMALON S.P.R.L.
    Inventors: Nathalie Ledee, Marie-Pierre Piccinni
  • Patent number: 9176145
    Abstract: A kit for determining for a female subject the implantation potential of embryos obtained or to be obtained by assisted fertilization is described. The kit includes at least one reagent suitable for detection of levels of FF G-CSF or FF G-CSF mRNA, such as anti-G-CSF antibody or a nucleic acid probe for detection of levels of G-CSF mRNA. The kit may also include a set of concentration standards of FF G-CSF and aspirator tips for removing an oocyte and follicular fluid.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: November 3, 2015
    Assignee: FEMALON S.P.R.L.
    Inventors: Nathalie Lédée, Marie-Pierre Piccinni
  • Publication number: 20140170219
    Abstract: Described are lyophilized compositions comprising cidofovir, hydroxypropyl methylcellulose (HPMC) or hydroxyethylcellulose (HEC) and, optionally, a plasticizer. In particular, described are such compositions that form a sheet-shaped porous solid matrix. Also described are methods for producing such compositions and their use in treating human papillomavirus (HPV) infections and HPV-associated malignancies, in particular, HPV lesions and cervical cancer.
    Type: Application
    Filed: July 13, 2012
    Publication date: June 19, 2014
    Applicants: UNIVERSITE LIBRE DE BRUXELLES, FEMALON S.P.R.L.
    Inventors: Marie Piette, Brigitte Evrard, Isabelle Coïaée
  • Publication number: 20120283673
    Abstract: A kit for determining for a female subject the implantation potential of embryos obtained or to be obtained by assisted fertilization is described. The kit includes at least one reagent suitable for detection of levels of FF G-CSF or FF G-CSF mRNA, such as anti-G-CSF antibody or a nucleic acid probe for detection of levels of G-CSF mRNA. The kit may also include a set of concentration standards of FF G-CSF and aspirator tips for removing an oocyte and follicular fluid.
    Type: Application
    Filed: July 2, 2012
    Publication date: November 8, 2012
    Applicant: Femalon S.A.
    Inventors: Nathalie Lédée, Marie-Pierre Piccinni
  • Patent number: 8211650
    Abstract: The present invention relates to an assay for determining the implantation potential of a plurality of embryos each obtained or to be obtained by assisted fertilization of an oocyte of a female subject, comprising measuring the levels of granulocyte-colony stimulating factor (G-CSF) in the follicular fluid (FF) present in the follicle from which each oocyte is derived, and determining the implantation potential of each embryo from the level of measured FF G-CSF. It also relates to a kit for carrying out the assay. It further relates to a method for assisted fertilization.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: July 3, 2012
    Assignee: Femalon S.A.
    Inventors: Nathalie Ledee, Marie-Pierre Piccinni, Raoul Lombroso