Abstract: The techniques relate to methods and apparatus for sealed fluid chambers. The device includes a sensor chip comprising a set of sensor elements configured to sense an analyte, and the set of sensor elements comprise an associated set of electrodes extending along the surface of the substrate. The device includes a fluid chamber comprising an edge proximate to the surface of the substrate, the fluid chamber comprising an inner portion in fluid communication with the set of sensor elements, wherein at least one electrodes extends from the inner portion of the chamber across the edge of the chamber and outside of the fluid chamber. The device includes a sealing member between the edge of the fluid chamber and the surface of the substrate such that the sealing member is disposed over at least a portion of the electrode that extends across the edge of the fluid chamber.

Abstract: A nanoelectric field effect sensor uses the field created by the surface charge profile of biomolecular binding to modulate the current flowing between a source and a drain. We have shown that a patterned side or top gate can be used to calibrate the biomolecular field modulation. This approach provides an electrical sensitivity characterization of the sensor before exposing it to sample fluid. Furthermore, a side gate or a top gate voltage with the right sign can be used to control the binding event during functionalization or sensing. For instance, a negative gate voltage can prevent binding of negatively charged proteins on a sensor. This approach of electric-field control of binding can be used in a differential sensor configuration as well. For instance, in a two-sensor single-bridge technique, one of the sensors can be exposed to a local electric field to prevent binding events, which can then be used for background cancellation in a second sensor, not exposed to the electric field.

Abstract: The techniques relate to methods and apparatus for conductance measurement. A device includes a fluid chamber, at least one sensor element configured to sense an analyte, wherein the at least one sensor element is in fluid communication with the fluid chamber, and a set of one or more electrodes in fluid communication with the fluid chamber for sensing a conductance of a fluid in the fluid chamber.

Abstract: This application describes a novel approach of wireless charging or powering of a sensor-based device used for in vivo diagnosis and monitoring. In addition to implantable or subcutaneous devices, this approach can also be used for wireless charging of wearable and handheld devices. Specifically, this application describes charging of diagnostic and monitoring devices used for disease detection and management. More specifically, this application describes a method to wirelessly power integrated devices designed to detect or monitor analytes (e.g. biological or chemical species) and release drugs into the body in response to a specific change in the body's vitals, detected by the device.

Abstract: Devices and methods for the detection of nucleic acids (e.g., RNA, DNA) are described. The nucleic acid can be obtained or derived from a pathogen, such as a virus. In one embodiment, the virus is a coronavirus (e.g., SARS-CoV-2) related to the disease COVID-19. Accordingly, devices and methods may be used in the field as point-of-care devices to test a subject (e.g., a patient) for the presence of the SARS-CoV-2 virus or another nucleic acid.

Abstract: The techniques relate to methods and apparatus for sensing an analyte. At least one sensor element is configured to sense an analyte, the at least one sensor element comprising a first portion and a second portion. A first current electrode is attached to the first portion and a second current electrode is attached to the second portion. A first measurement electrode is attached to the first portion and a second measurement electrode is attached to the second portion.

Abstract: Nonlinear acoustic media and related methods are described herein. The nonlinear acoustic media are configured to generate higher harmonic output signals from a single-frequency input signal. The higher harmonic output signals can be generated through the coupling of an acoustic dielectric medium to a nonlinear piezoelectric medium having four ports.

Abstract: A semiconductor sensor-based near-patient diagnostic system and related methods.

Abstract: Aspects of the present disclosure provide measurement devices and methods for detecting electrical characteristics of devices under test (DUTs), such as semiconductor nanowires. Techniques described herein provide programmable measurement devices that may be implemented in a compact form factor while being able to perform reliable measurements. In some embodiments, measurement devices described herein may be programmed to modulate signals for transmitting to a DUT, and may demodulate signals from the DUTs adaptively using self-programming techniques described herein. Such self-programming may include applying a programmable phase delay to oscillator signals used during demodulation. In some embodiments, such measurement devices may be implemented on a single circuit board, in a single integrated circuit package, or even on a single solid-state semiconductor die. Techniques described herein may enable reliable, inexpensive, and small-scale fluid sample measurement devices.

Abstract: A semiconductor sensor-based near-patient diagnostic system and related methods.

Abstract: Systems and methods for removing ions from a sample (i.e., desalting) are generally described. In some embodiments, “desalting” comprises removing ions from a sample, the sample also comprising an analyte, such as a protein, a hormone, or an antigen. Unwanted ions can increase the noise when detecting or sensing a signal from an analyte within the sample.

Abstract: Semiconductor-based sensor devices and methods for detection of biological agents are described herein.

Abstract: A MEMS resonator is described.

Abstract: Systems and methods for detection of biological agents are generally described. Target biological agents may be detected by use of a sensor, which in some situations is a nanowire. An external electric field is applied in some embodiments to induce an electric dipole. The induced electric dipole is detected, allowing detection of the biological agent.

Abstract: Articles and systems for separating micro-sized analytes.

Abstract: Some embodiments relate to a device with a fluidic stack that includes a filter, a fluidic block adjacent to the filter that includes a first channel through the fluidic block, a first layer adjacent to the fluidic block that includes at least a portion of a second channel that is in fluid communication with the first channel, and a sensor adjacent to the first layer and in fluid communication with the second channel. The device can include a fluid reservoir that includes one or more dimensions of the second channel and/or the sensor, and a reference electrode disposed within the fluid reservoir.

Abstract: The techniques relate to methods and apparatus for determining data indicative of a concentration of an analyte in a fluid. First data indicative of a first property measurement of a first sensor while in fluid communication with the fluid is accessed. Second data indicative of a second property measurement of a second sensor in fluid communication with the fluid is accessed. A set of one or more parameters related to the first sensor, the second sensor, or both are accessed. The data indicative of the concentration of the analyte in the fluid is determined based on the first property measurement, the second property measurement, and the set of one or more parameters.

Abstract: Methods, systems and devices related to wafer level probing of electrical biosensors.

Abstract: The techniques relate to methods and apparatus for conductance measurement. A device includes a fluid chamber, at least one sensor element configured to sense an analyte, wherein the at least one sensor element is in fluid communication with the fluid chamber, and a set of one or more electrodes in fluid communication with the fluid chamber for sensing a conductance of a fluid in the fluid chamber.

Abstract: Systems and methods for detection of biological agents are generally described. Target biological agents may be detected by use of a sensor, which in some situations is a nanowire. An external electric field is applied in some embodiments to induce an electric dipole. The induced electric dipole is detected, allowing detection of the biological agent.