Abstract: A laser pulse energy amplification device and method, and a femtosecond laser are provided. The laser pulse energy amplification device includes a pulse amplifier and a pulse shaper that are connected in sequence. The pulse amplifier is connected to an output port of a seed laser source and is connected to the pulse shaper that outputs a femtosecond laser pulse. The seed laser source is configured to generate and input a seed laser pulse to the pulse amplifier. The pulse amplifier is configured to introduce a nonlinear phase shift into the seed laser pulse, perform energy amplification and spectral stretching, and output an energy-amplified laser pulse with a nonlinear phase to the pulse shaper. The pulse shaper is configured to measure a shape and/or the nonlinear phase of the energy-amplified laser pulse, and shape the energy-amplified laser pulse according to the shape and/or the nonlinear phase.

Abstract: A laser pulse shaping device and method, a pulse shaper, and an optical system are provided. The laser pulse shaping device includes a pulse shaper provided in an optical path connected to a laser source, a laser detection device provided at an actual position of a target of a laser pulse, and the laser source configured to generate the laser pulse, which is transmitted to the target through the optical path. The laser detection device is configured to measure and send an optical parameter of the laser pulse transmitted to the target to the control device. The control device is configured to calculate a phase compensation parameter according to the optical parameter and control the pulse shaper to compensate a phase of the laser pulse transmitted through the optical path according to the phase compensation parameter, such that the optical parameter of the laser pulse reaches a target value.

Abstract: A laser pulse energy amplification device and method, and a femtosecond laser are provided. The laser pulse energy amplification device includes a pulse amplifier and a pulse shaper that are connected in sequence. The pulse amplifier is connected to an output port of a seed laser source and is connected to the pulse shaper that outputs a femtosecond laser pulse. The seed laser source is configured to generate and input a seed laser pulse to the pulse amplifier. The pulse amplifier is configured to introduce a nonlinear phase shift into the seed laser pulse, perform energy amplification and spectral stretching, and output an energy-amplified laser pulse with a nonlinear phase to the pulse shaper. The pulse shaper is configured to measure a shape and/or the nonlinear phase of the energy-amplified laser pulse, and shape the energy-amplified laser pulse according to the shape and/or the nonlinear phase.

Abstract: A laser pulse shaping device and method, a pulse shaper, and an optical system are provided. The laser pulse shaping device includes a pulse shaper provided in an optical path connected to a laser source, a laser detection device provided at an actual position of a target of a laser pulse, and the laser source configured to generate the laser pulse, which is transmitted to the target through the optical path. The laser detection device is configured to measure and send an optical parameter of the laser pulse transmitted to the target to the control device. The control device is configured to calculate a phase compensation parameter according to the optical parameter and control the pulse shaper to compensate a phase of the laser pulse transmitted through the optical path according to the phase compensation parameter, such that the optical parameter of the laser pulse reaches a target value.

Abstract: A multimodal signal acquisition device and method, and a laser image system are provided. The multimodal signal acquisition device is configured to acquire a multimodal signal generated by a laser pulse that irradiates a sample and includes an independent-channel acquisition module and a spectral signal processing device. The independent-channel acquisition module is provided with multiple independent spectral signal acquisition channels, each of which corresponds to a spectral signal of a specific spectral range in the multimodal signal. Each of the spectral signal acquisition channels acquires the multimodal signal, filters the corresponding spectral signal of the specific spectral range from the multimodal signal, and sends the spectral signal to the spectral signal processing device. The spectral signal processing device is configured to receive the spectral signal acquired by each of the spectral signal acquisition channels and perform imaging and superposed output of each spectral signal.

Abstract: A femtosecond laser multimodality molecular imaging system includes a near-infrared pulse generation device for providing near-infrared pulses with a central wavelength of 1010 nm to 1100 nm and a spectral width of less than 25 nm. The near-infrared pulses can excite an optical medium with strong nonlinearity to generate the femtosecond laser pulses with ultra-wide spectrum. A pulse measurement compression and control module measures and compensates the accumulated dispersion of the femtosecond laser pulses arriving at the tissue sample, so as to eliminate the “time domain broadening” effect as much as possible. The obtained shortest pulses can interact with the tissue sample to generate spectral signals from different modalities, thus providing a variety of nonlinear molecular image modalities.

Abstract: A femtosecond laser multimodality molecular imaging system includes a near-infrared pulse generation device for providing near-infrared pulses with a central wavelength of 1010 nm to 1100 nm and a spectral width of less than 25 nm. The near-infrared pulses can excite an optical medium with strong nonlinearity to generate the femtosecond laser pulses with ultra-wide spectrum. A pulse measurement compression and control module measures and compensates the accumulated dispersion of the femtosecond laser pulses arriving at the tissue sample, so as to eliminate the “time domain broadening” effect as much as possible. The obtained shortest pulses can interact with the tissue sample to generate spectral signals from different modalities, thus providing a variety of nonlinear molecular image modalities.