Patents Assigned to Fermion Oy
  • METHOD FOR PRODUCING NITROFURANTOIN ANHYDRATE, AND PRODUCT THEREOF
    Publication number: 20230212156
    Abstract: The present disclosure relates to a novel process for production of crystalline particles of nitrofurantoin anhydrate, the crystalline particles of nitrofurantoin anhydrate being obtained by a process as disclosed, and pharmaceutical compositions as disclosed including crystalline particles of nitrofurantoin anhydrate.
    Type: Application
    Filed: May 11, 2021
    Publication date: July 6, 2023
    Applicant: FERMION OY
    Inventors: Oskari KARJALAINEN, Mikko LESKINEN
  • Synthesis of 2-indolinone derivatives
    Patent number: 11261158
    Abstract: The present disclosure relates to a preparation method of methyl (E)-1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate from methyl 2-oxoindoline-6-carboxylate using high reaction temperatures and a reaction solvent enabling azeotropic removal of acetic acid during the reaction.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: March 1, 2022
    Assignee: FERMION OY
    Inventors: Antti Piisola, Jan Tois
  • SYNTHESIS OF 2-INDOLINONE DERIVATIVES
    Publication number: 20200299275
    Abstract: The present disclosure relates to a preparation method of methyl (E)-1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate from methyl 2-oxoindoline-6-carboxylate using high reaction temperatures and a reaction solvent enabling azeotropic removal of acetic acid during the reaction.
    Type: Application
    Filed: November 2, 2018
    Publication date: September 24, 2020
    Applicant: Fermion Oy
    Inventors: Antti PIISOLA, Jan TOIS
  • Processes for the preparation of Vemurafenib
    Patent number: 10407427
    Abstract: Novel processes are disclosed for manufacture of N-(3-(5-(4-chlorophenyl)-l H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (I), wherein no protection-deprotection sequences or halogenation steps are required and use of palladium catalysts is minimized.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: September 10, 2019
    Assignee: FERMION OY
    Inventor: Antti Kataja
  • NEW PROCESSES FOR THE PREPARATION OF VEMURAFENIB
    Publication number: 20190194197
    Abstract: Novel processes are disclosed for manufacture of N-(3-(5-(4-chlorophenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (I), wherein no protection-deprotection sequences or halogenation steps are required and use of palladium catalysts is minimized.
    Type: Application
    Filed: June 30, 2017
    Publication date: June 27, 2019
    Applicant: Fermion Oy
    Inventor: Antti KATAJA
  • Process for the preparation of ospemifene
    Patent number: 9321712
    Abstract: The present invention is related to the process for the preparation ospemifene or (Z)-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol (I) and to intermediate compounds used in the process.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: April 26, 2016
    Assignee: FERMION OY
    Inventors: Jan Tois, Ainoliisa Pihko, Arne Grumann
  • A PROCESS FOR THE PREPARATION OF OSPEMIFENE
    Publication number: 20150321983
    Abstract: The present invention is related to the process for the preparation ospemifene or (Z)-2[4-(4-chloro-1,2-diphen-yl-but-1-enyl)phenoxy]ethanol (I) and to intermediate compounds used in the process.
    Type: Application
    Filed: October 17, 2013
    Publication date: November 12, 2015
    Applicant: Fermion Oy
    Inventor: Jan TOIS
  • PROCESS FOR THE PREPARATION OF OSPEMIFENE
    Publication number: 20150274624
    Abstract: The present invention is related to the process for the preparation ospemifene or (Z)-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol (I) and to intermediate compounds used in the process.
    Type: Application
    Filed: October 17, 2013
    Publication date: October 1, 2015
    Applicant: Fermion Oy
    Inventors: Jan Tois, Ainoliisa Pihko, Arne Grumann
  • Process for the preparation of quetiapine
    Patent number: 8420807
    Abstract: The invention relates to a method for the preparation of 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo [b,f]-1,4-thiazepine and pharmaceutically acceptable salts thereof comprising the reaction of 1-[2-(hydroxyethoxy)-ethyl]piperazine with dibenzo[b,f][1,4]thiazepin-11-ylamine.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: April 16, 2013
    Assignee: Fermion Oy
    Inventors: Arne Grumann, Dzintra Muceniece, Otto Soidinsalo
  • Crystallization process of quetiapine hemifumarate
    Patent number: 8044038
    Abstract: The present invention relates to a process for preparing crystalline quetiapine hemifumarate, which comprises crystallizing or re-crystallizing quetiapine hemifumarate from a mixture of water and a water soluble alcohol.
    Type: Grant
    Filed: September 28, 2006
    Date of Patent: October 25, 2011
    Assignee: Fermion Oy
    Inventors: Petteri Rummakko, Arne Grumann, Soini Huhta, Tuomas Koiranen
  • Quetiapine hemifumarate purification by crystallization
    Patent number: 8044039
    Abstract: The present invention relates to a process for preparing and purifying crystalline quetiapine hemifumarate, which comprises preparing crystalline quetiapine hemifumarate via a crystalline salt, which is not a salt of fumaric acid.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: October 25, 2011
    Assignee: Fermion Oy
    Inventors: Arne Grumann, Soini Huhta, Petteri Rummakko, Viesturs Lusis
  • PROCESS FOR THE PREPARATION OF QUETIAPINE
    Publication number: 20110112290
    Abstract: The invention relates to a method for the preparation of 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f]-1,4-thiazepine and pharmaceutically acceptable salts thereof comprising the reaction of 1-[2-(hydroxyethoxy)-ethyl]piperazine with dibenzo[b,f][1,4]thiazepin-11-ylamine.
    Type: Application
    Filed: January 30, 2009
    Publication date: May 12, 2011
    Applicant: FERMION OY
    Inventors: Arne Grumann, Dzintra Muceniece, Otto Soidinsalo
  • Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin
    Patent number: 7910737
    Abstract: The invention discloses the preparation method of 7-ethyl-10-hydroxycamptothecin from 4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione and 1-(2-amino-5-hydroxyphenyl)-propan-1-one using higher reaction temperature and faster heating to that temperature.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: March 22, 2011
    Assignee: Fermion Oy
    Inventor: Ilpo Laitinen
  • Preparation of quetiapine
    Patent number: 7863441
    Abstract: The present invention discloses a process for the preparation of quetiapine, which comprises the ring closure of a compound of the formula shown below, as well as novel intermediates in the process.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: January 4, 2011
    Assignee: Fermion Oy
    Inventors: Petteri Rummakko, Soini Huhta, Arne Grumann
  • Preparation method for quetiapine
    Patent number: 7858777
    Abstract: The present invention discloses a process for the preparation of quetiapine, which comprises the ring closure and deprotection of a compound of the formula (I), as well as novel intermediates in the process.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: December 28, 2010
    Assignee: Fermion Oy
    Inventors: Leif Hilden, Arne Grumann, Soini Huhta, Petteri Rummakko
  • Preparation method
    Patent number: 7767813
    Abstract: The present invention is directed to a novel method for the preparation of high purity irinotecan. This can be achieved by eliminating the excess of the other reagent, bipiperidinyl-1?-carbonyl chloride after it has reacted with 7-ethyl-10-hydroxy camptothecin and crystallizing the final product from a suitable solvent.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: August 3, 2010
    Assignee: Fermion Oy
    Inventors: Ilpo Laitinen, Hannele Nikander
  • Process for producing [1,4?] bipiperidinyl-1?-carbonyl chloride or hydrochloride thereof
    Patent number: 7662964
    Abstract: The present invention is related to a process for the preparation of [1,4?]bipiperidinyl-1?-carbonyl chloride or its hydrochloride using methylene chloride as a solvent in the reaction of 4-piperidinopiperidine with phosgene and the removing the reaction solvent by using an additional distillation solvent to raise the distillation temperature.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: February 16, 2010
    Assignee: Fermion Oy
    Inventor: Ilpo Laitinen
  • Quetiapine Hemifumarate Purification by Crystallization
    Publication number: 20090156802
    Abstract: The present invention relates to a process for preparing and purifying crystalline quetiapine hemifumarate, which comprises preparing crystalline quetiapine hemifumarate via a crystalline salt, which is not a salt of fumaric acid.
    Type: Application
    Filed: October 26, 2006
    Publication date: June 18, 2009
    Applicant: FERMION OY
    Inventors: Arme Grumann, Soini Huhta, Petteri Rummakko, Viesturs Lusis
  • Crystallization process
    Publication number: 20090137844
    Abstract: The invention relates to a process for the production of tamsulosin hydrochloride crystals where the crystal size distribution is controlled by controlling the temperature where hydrochloric acid is added to the reaction mixture.
    Type: Application
    Filed: June 14, 2006
    Publication date: May 28, 2009
    Applicant: Fermion Oy
    Inventors: Arne Grumann, Soini Huhta, Eila Luukkonen, Tuomas Koiranen
  • PROCESS FOR PREPARING A COMPOUND
    Publication number: 20090082597
    Abstract: The invention relates to the use of copper-catalyzed nucleophilic aromatic substitution reaction for preparing 3-aryloxy-3-arylpropylamines and more specifically to a method of preparing certain 3-aryloxy-3-arylpropylamines and the pharmaceutically acceptable addition salts thereof, comprising reacting an amino alcohol with a haloaromatic compound in the presence of a base and a catalytic copper source, and in the absence of a separate ligand.
    Type: Application
    Filed: July 14, 2006
    Publication date: March 26, 2009
    Applicant: FERMION OY
    Inventors: Arne Grumann, Kari Lappalainen, Peter Maiwald, Pekka Pietikainen, Petteri Rummakko