Abstract: A tetracycline pharmaceutical composition having a core element containing a tetracycline antibiotic and a core coating which dissolves more slowly in the stomach than in the intestine. Administration of the composition to a human results in drug concentrations in the blood which are bioequivalent to those achieved with immediate release formulations.
Type:
Grant
Filed:
May 14, 1990
Date of Patent:
January 11, 1994
Assignee:
F. H. Faulding & Co., Ltd.
Inventors:
Mark Dwyer, Mark C. Fisher, Angelo M. Morella