Patents Assigned to Fibralign Corporation
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Patent number: 11273235Abstract: Materials and methods are provided to direct the formation of new lymphatics and to reconnect the disrupted lymphatic network. These materials and methods enable to improve survival of lymph nodes and lymph node fragments and their integration into a lymphatic network, following lymph node and lymph node fragments transplantation. The treatment or prevention of lymphedema is also addressed. In certain embodiments, a bundle of fibers or fibrils presented in the composition is effective to stimulate and direct the formation of new lymphatic and blood vessels. The bundle of fibers or fibrils presented in the composition is effective to promote survival of the lymph node or lymph node fragments and integration of the lymph node or lymph node fragments into a lymphatic network in the mammalian subject, at the site of transfer or transplantation.Type: GrantFiled: October 10, 2014Date of Patent: March 15, 2022Assignee: Fibralign CorporationInventors: Catarina Hadamitzky, Tatiana Zaitseva, Michael V. Paukshto
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Patent number: 11013826Abstract: In general, the present invention is related to biopolymer and biocomposite materials and structures, and methods of making and using the same. In some embodiments, the present invention is directed to oriented collagen based biocomposite materials and structures, and methods of making.Type: GrantFiled: September 21, 2018Date of Patent: May 25, 2021Assignee: Fibralign CorporationInventors: Mikhail Vitoldovich Paukshto, David Harwood McMurtry, Tatiana Zaitseva
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Patent number: 10639450Abstract: A novel medical device and a method for delivery of a scaffold for treatment of secondary lymphedema and ischemia is provided. In some embodiments a catheter medical device and a magnetic guidance method are provided for delivering cell-seeded implants for guided lymphatic regeneration.Type: GrantFiled: July 24, 2013Date of Patent: May 5, 2020Assignee: FIBRALIGN CORPORATIONInventors: David H. McMurtry, Michael V. Paukshto, Tatiana S. Zaitseva
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Patent number: 10238769Abstract: Embodiments of the present invention relate to a therapeutic device (graft) comprising a collagen membrane having an aligned uniaxial or biaxial structure such that mammalian cells plated on the membrane align mainly along the direction of the collagen fibrils. In a further aspect, a graft comprising a substantially tubular body, wherein the body has an exterior surface, an interior surface, and at least one lumen extending therethrough such that a fluid flow through the lumen can direct mammalian cell migration. In a further aspect, mammalian cells or growth and angiogenic factors can be optionally attached to the exterior and/or interior surface of the substantially tubular body. In various aspects, the graft can be used as a vascular prosthesis, a stent, or a nerve regeneration scaffold. Methods of preparing and implanting same are also provided.Type: GrantFiled: October 11, 2012Date of Patent: March 26, 2019Assignees: Fibralign Corporation, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Michael V. Paukshto, John P. Cooke, Tatiana S. Zaitseva, Ngan F. Huang, Gerald G. Fuller, George R. Martin
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Patent number: 10086079Abstract: In general, the present invention is related to biopolymer and biocomposite materials and structures, and methods of making and using the same. In some embodiments, the present invention is directed to oriented collagen based biocomposite materials and structures, and methods of making.Type: GrantFiled: June 24, 2013Date of Patent: October 2, 2018Assignee: Fibralign CorporationInventors: Mikhail Vitoldovich Paukshto, David Harwood McMurtry, George R. Martin, Tatiana Zaitseva
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Patent number: 10065046Abstract: Embodiments of the present invention relate generally to the field of tissue repair and regeneration. More specifically, embodiments of the present invention relate to medical devices, materials or constructs, such as conductive biocompatible polymers having one or more networks of metal nanowires that enhance tissue repair and regeneration using electromagnetic fields.Type: GrantFiled: July 15, 2011Date of Patent: September 4, 2018Assignee: Fibralign CorporationInventors: Michael Paukshto, George Martin, John Cooke
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Patent number: 9724308Abstract: Embodiments of the present invention relate generally to the field of tissue repair and regeneration. More specifically embodiments of present disclosure relate to devices or constructs and methods to prepare various devices or constructs useful in directing cellular repair and controlling tissue regeneration to prevent or minimize postsurgical or post traumatic adhesions, excessive scars and/or fibrotic reactions of injured tissues.Type: GrantFiled: September 10, 2011Date of Patent: August 8, 2017Assignee: Fibralign CorporationInventors: Michael V. Paukshto, George R. Martin, David H. McMurtry
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Publication number: 20140081070Abstract: Embodiments of the present invention relate generally to the field of tissue repair and regeneration. More specifically embodiments of present disclosure relate to devices or constructs and methods to prepare various devices or constructs useful in directing cellular repair and controlling tissue regeneration to prevent or minimize postsurgical or post traumatic adhesions, excessive scars and/or fibrotic reactions of injured tissues.Type: ApplicationFiled: September 10, 2011Publication date: March 20, 2014Applicant: FIBRALIGN CORPORATIONInventors: Michael V. Paukshto, George R. Martin, David H. McMurtry
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Publication number: 20130287744Abstract: In general, the present invention is related to biopolymer and biocomposite materials and structures, and methods of making and using the same. In some embodiments, the present invention is directed to oriented collagen based biocomposite materials and structures, and methods of making.Type: ApplicationFiled: June 24, 2013Publication date: October 31, 2013Applicant: Fibralign CorporationInventors: Mikhail Vitoldovich Paukshto, David Harwood McMurtry, George R. Martin, Tatiana Zaitseva
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Patent number: 8513382Abstract: In general, the present invention is related to biopolymer and biocomposite materials and structures, and methods of making and using the same. In some embodiments, the present invention is directed to oriented collagen based biocomposite materials and structures, and methods of making.Type: GrantFiled: August 11, 2009Date of Patent: August 20, 2013Assignee: Fibralign CorporationInventors: Mikhail Vitoldovich Paukshto, David Harwood McMurtry, George R. Martin, Tatiana Zaitseva, Yuri Alexandrovich Bobrov
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Patent number: 8492332Abstract: In general, the present invention is related to collagen compositions and thin films, and to methods of making and using the same. In some embodiments, the present invention is directed to “uniaxial pattern” or “linear pattern” collagen materials, compositions and thin films, and methods of making.Type: GrantFiled: April 18, 2008Date of Patent: July 23, 2013Assignee: Fibralign CorporationInventors: Mikhail Vitoldovich Paukshto, David Harwood McMurtry, Yuri Alexandrovich Bobrov, Eric Eugene Sabelman
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Patent number: 8227574Abstract: In general, the present invention is related to collagen compositions and thin films, and to methods of making and using the same. In some embodiments, the present invention is directed to “woven pattern” or “basket pattern” collagen compositions and thin films, and methods of making.Type: GrantFiled: December 5, 2007Date of Patent: July 24, 2012Assignees: Fibralign Corporation, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mikhail Vitoldovich Paukshto, David Harwood McMurtry, Gerald G. Fuller, Yuri Alexandrovich Bobrov, John E. Kirkwood
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Publication number: 20120065703Abstract: Embodiments of the present invention relate generally to the field of tissue repair and regeneration. More specifically, embodiments of the present invention relate to medical devices, materials or constructs, such as conductive biocompatible polymers having one or more networks of metal nanowires that enhance tissue repair and regeneration using electromagnetic fields.Type: ApplicationFiled: July 15, 2011Publication date: March 15, 2012Applicant: Fibralign CorporationInventors: Michael Paukshto, George Martin, John Cooke
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Patent number: 8028647Abstract: A liquid coating applicator with a very precise means for controlling gap thickness as well as adapting to non-planar discontinuities in the substrate.Type: GrantFiled: November 20, 2007Date of Patent: October 4, 2011Assignee: Fibralign CorporationInventors: David Harwood McMurtry, Mikhail Vitoldovich Paukshto, Yuri A. Bobrov