Abstract: The present invention relates to a composition comprising fibrinogen for increasing the sensitivity of microorganisms for an antimicrobial compound. The invention may be used to alleviate the problem of antimicrobial resistance of microbial biofilms or aggregates, for example of microbial biofilms on medical devices, in particular indwelling devices, or in wound beds. The device or wound bed may be (pre-)coated with fibrinogen to increase antimicrobial susceptibility. The antimicrobial may be supplied separately from or together with the fibrinogen.

Abstract: The present invention relates to compositions comprising fibrinogen gamma prime variants for use in the treatment or prevention of an infection and methods of administering the composition. The fibrinogen gamma prime variants in the composition comprise at least one fibrinogen gamma prime polypeptide chain. The compositions for use according to the invention may also comprise other fibrinogen variants. Compositions comprising fibrinogen gamma prime variants according to the invention improve survival time after infection up to more than 200 percent compared to WT fibrinogen. They may be used both therapeutically and prophylactically.