Abstract: The invention concerns the preparation and use of a biocompatible, biocomponent material constituted by: (a) a three-dimensional matrix of hyaluronic acid derivatives witle a structure containing empty spaces; (b) a porous, three-dimensional matrix constituted by a ceramic material; (c) possibly containing pharmacologically or biologically active ingredients.
Abstract: Methods of using an injectable or implantable rod-shaped formulation for delivery of osteogenic proteins to treat osteoporotic and/or osteopenic bone are disclosed. The formulation comprises hyaluronic acid derivatives and osteogenic proteins, and optional excipients and active ingredients such as a bone resorption inhibitor.
Abstract: Use of a biological material containing: e) a three-dimensional matrix based on a hyaluronic acid derivative and optionally f) chondrocytes and/or mesenchymal cells partially or completely differentiated towards chondrocytes for the preparation of a graft to be surgically implanted into a joint cartilage damaged by or to be protected against a degenerative and/or inflammatory pathology.
Type:
Grant
Filed:
February 25, 2005
Date of Patent:
November 30, 2010
Assignee:
Fidia Advanced Biopolymers S.r.l.
Inventors:
Anthony P. Hollander, Alessandria Pavesio
Abstract: The invention relates to use of a biological material containing cells supported on three-dimensional scaffolds containing at least one hyaluronic acid derivative for the preparation of grafts suitable for application by arthroscopy, and a kit of surgical instruments for implanting said biological material by arthroscopy.
Type:
Grant
Filed:
December 27, 2001
Date of Patent:
May 25, 2010
Assignee:
Fidia Advanced Biopolymers S.r.l.
Inventors:
Lanfranco Callegaro, Maurilio Marcacci, Sergio Di Fede
Abstract: A composite material comprising: (i) hyaluronic acid and/or hyaluronic acid derivatives, (ii) demineralised bone and/or biocompatible partially or totally demineralised bone tissue matrix and/or biocompatible and bioresorbable ceramic materials. This material preferably associated with at least one layer comprising a hyaluronic acid derivative may be used in the preparation of bone substitutes or grafts for the regeneration or formation of bone tissue in surgery.
Abstract: An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
Type:
Grant
Filed:
January 18, 2007
Date of Patent:
October 27, 2009
Assignees:
Genetics Institute, LLC, Fidia Advanced Biopolymers S.R.L.
Inventors:
Hyun Kim, Rebecca Li, Alessandra Pavesio, Lanfranco Callegaro, Howard Seeherman, John Wozney
Abstract: The present invention relates to hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxy groups of propiophenone derivatives, to the hydrogel materials consisting of the said hyaluronic acid ester derivatives, to their preparation process by photocuring of the hyaluronic acid ester derivatives, and their use in the biomedical, sanitary and surgical fields, and in the medical field as controlled release systems for drugs.
Abstract: New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesions.
Abstract: A process for the preparation of polymer scaffolds containing a pharmacologically and/or biologically active protein molecule involving the following steps: neutralisation of the scaffold with a basic substance or a buffer solution; drying the scaffold; imbibition of the scaffold with a predefined quantity of a pharmacologically and/or biologically active protein molecule.
Abstract: The present invention concerns the preparation of composite biomaterials constituted by hyaluronic acid and the derivatives thereof in combination with polymers that have electrically conductive properties. In particular, the methods of preparing biomedical devices formed by a two- or three-dimensional polysaccharide matrix and by an electrically conductive membrane. The matrix is constituted by hyaluronic acid derivatives in the form of membranes, woven fabrics, nonwoven felts, meshes, gauzes, guide channels or sponges, while the electrically conductive membrane is constituted by a film of polypyrrole (polymer conductor) in combination with hyaluronic acid or a derivative thereof (doping agent).
Abstract: A composite material comprising: (i) hyaluronic acid and/or hyaluronic acid derivatives, (ii) demineralised bone and/or biocompatible partially or totally demineralised bone tissue matrix and/or biocompatible and bioresorbable ceramic materials. This material preferably associated with at least one layer comprising a hyaluronic acid derivative may be used in the preparation of bone substitutes or grafts for the regeneration or formation of bone tissue in surgery.
Abstract: The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical hemostatic activity, to be used in both venous and arterial vascular anastomoses to create a physical hemostatic barrier and to prevent scar tissue formation and formation of post-surgical adherence of the vessels to the surrounding tissues.
Abstract: An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
Type:
Grant
Filed:
October 13, 2000
Date of Patent:
March 13, 2007
Assignees:
Genetics Institute, LLC, Fidia Advanced Biopolymers S.R.L.
Inventors:
Hyun Kim, Rebecca Li, Alessandra Pavesio, Lanfranco Callegaro, Howard Seeherman, John Wozney
Abstract: Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable non-woven fabric materials for use in surgery for the guided regeneration of tissues. The non-woven fabric materials are comprised of threads embedded in a matrix, wherein both the matrix and the threads can be comprised of esters of hyaluronic acid, used singly or in combination, or esters of hyaluronic acid in combination with esters of alginic acid or other polymers.
Abstract: The present invention relates to a biological material having a matrix which contains at least one derivative of hyaluronic acid on which endothelial cells, glandular cells such as islets of Langerhans and liver cells, skin adnexa, germinative cells of hair bulbs, and kerinatocytes are grown, optionally in presence of a medium treated with fibroblasts or in a co-culture with fibroblasts. A process for the production of said biologic materials and the use of such materials for human and veterinary applications such as cardiovascular and oncological surgery, in connection with transplants, for enhancing the biological process of tissue vascularization and for aesthetic use, and also for the screening of medicaments or toxic substances and as a support in the process of gene transfection. The biological material is based on an efficacious cell culture and a biocompatible and biodegradable three-dimensional matrix containing a hyaluronic acid derivative.
Type:
Grant
Filed:
December 7, 1999
Date of Patent:
October 12, 2004
Assignee:
Fidia Advanced Biopolymers S.r.l.
Inventors:
Giovanni Abatangelo, Lanfranco Callegaro
Abstract: New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesions.
Abstract: Disclosed is an injectable, biocompatible and biodegradable composition, comprising at least one hyaluronic acid benzyl ester or auto-cross-linked derivative, in combination with at least one mammalian cell and/or at least one pharmacologically or biologically active substance and/or micro-particles such as fibres, granules, microspheres or sponge fragments of a hyaluronic acid derivative.
Type:
Application
Filed:
January 6, 2004
Publication date:
July 22, 2004
Applicant:
Fidia Advanced Biopolymers, S.r.l.
Inventors:
Marco Radice, Andrea Pastorello, Alessandra Pavesio, Lanfranco Callegard
Abstract: New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesion.
Abstract: A three-dimensional prosthesis is described in the shape of a body part comprising at least one three-dimensional matrix having an essentially fibrous or porous structure and containing a hyaluronic acid derivative, said prosthesis, contains at least two of said three-dimensional matrixes, the first of said three-dimensional matrixes incorporating or being adhered to the second and possible further matrixes, said three-dimensional matrix(es) optionally inicorporating and/or being adhered to a bidimensional perforated matrix and containing a hyaluronic acid derivative. This prosthesis is used for reconstruction of human or animal body part.
Type:
Grant
Filed:
December 8, 2000
Date of Patent:
November 4, 2003
Assignee:
Fidia Advanced Biopolymers S.r.l.
Inventors:
Andrea Pastorello, Marco Radice, Lanfranco Callegaro
Abstract: The application discloses esters of hyaluronic acid, wherein a first part of the carboxylic functions is esterified with an araliphatic alcohol and a second part is esterified with at least one long-chain, straight aliphatic alcohol with between 10 and 22 carbon atoms. The possible remaining non-esterified carboxylic functions, if present, are salified. The application further discloses biocompatible threads having a multifilament conformation comprising filaments formed by the aforesaid esters, and their use in the fields of medicine and surgery.