Patents Assigned to Fidia Farmaceutici S.p.A.
  • Pharmaceutical compositions containing phosphatidylserine and curcumin
    Patent number: 9381204
    Abstract: The present invention describes and claims stable pharmaceutical compositions and/or food supplements based on phosphatidylserine (PS) and curcumin, which are consequently devoid of degradation products, for use in the prevention and treatment of disorders associated with brain aging, and in the prevention and treatment of osteoporosis and/or osteoarthritis.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: July 5, 2016
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Giovanni Gennari, Susi Panfilo
  • BACTERIAL HYALURONIDASE AND PROCESS FOR ITS PRODUCTION
    Publication number: 20160168554
    Abstract: The present invention relates to a hyaluronidase from S. koganeiensis, applications thereof and a method for the production thereof.
    Type: Application
    Filed: June 13, 2014
    Publication date: June 16, 2016
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Luciano MESSINA, Luca MUSUMECI, Susanna VACCARO
  • PHARMACEUTICAL COMPOSITIONS COMPRISING COLLAGEN AND SODIUM HYALURONATE
    Publication number: 20160114003
    Abstract: The present invention relates to pharmaceutical compositions comprising collagen and hyaluronic acid, and optionally containing silver. Said compositions may be in the form of a hydrogel, pad or dry spray. The invention also relates to the preparation process of said compositions in pad form. Finally, the invention relates to the use of the compositions for the treatment of skin lesions.
    Type: Application
    Filed: May 29, 2014
    Publication date: April 28, 2016
    Applicants: FIDIA FARMACEUTICI S.P.A., EURORESEARCH S.R.L.
    Inventors: Giovanni GENNARI, Susi PANFILO, Juan Francisco SCALESCIANI
  • Sulphated hyaluronic acid for treating degenerative osteoarthritis
    Patent number: 9295690
    Abstract: This invention relates to oral and intra-articular formulations based on sulphated hyaluronic acid which are effective in the treatment of degenerative osteoarthritis.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: March 29, 2016
    Assignee: FIDIA FARMACEUTICI S.p.A.
    Inventors: Lanfranco Callegaro, Davide Renier
  • Method for obtaining recombinant host bacterial cells that produce hyaluronic acid
    Patent number: 9290785
    Abstract: The present invention relates to a method for the production of hyaluronic acid (HA) in Bacillus subtilis and Escherichia coli through plasmid vectors wherein the gene is under the control of strong promoter Pgrac, and a system for the selection of stable bacterial strains for the production of high levels of hyaluronic acid.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: March 22, 2016
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Vincenza Corsa, Alessandro Negro, Susanna Vaccaro, Luciano Messina
  • Use of conjugates of hyaluronic acid in the local treatment of hyperproliferative skin diseases
    Patent number: 9283284
    Abstract: The use is described of a conjugate between hyaluronic acid or a derivative thereof and antitumoral drugs for the preparation of pharmaceutical compositions for the topical treatment of hyperproliferative skin diseases.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: March 15, 2016
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Davide Renier, Susy Panfilo
  • PHARMACEUTICAL COMPOSITIONS CONTAINING HYALURONIC ACID FOR USE IN THE TREATMENT OF BLACK DISC DISEASE
    Publication number: 20160067274
    Abstract: The present invention describes and claims pharmaceutical compositions in gel form for use in the treatment of intervertebral disc degeneration, in particular the forms of dehydration and emptying of the nucleus pulposus known as “black disc disease”. These compositions comprise a hyaluronic acid derivative which forms hydrogels with precise rheological characteristics that make it ideal for filling the nucleus pulposus.
    Type: Application
    Filed: April 23, 2014
    Publication date: March 10, 2016
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Nicola GIORDAN, Pierangelo BELLATO
  • Compositions with antibacterial and wound healing activity
    Patent number: 9265793
    Abstract: The present invention relates to compositions based on silver and hyaluronic acid and their use in the management of cutaneous lesions of various origin (acute and chronic wounds, ulcerations, burns, etc.) mainly when characterized by the presence of exudate and hence at high risk of infection.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: February 23, 2016
    Assignee: FIDIA FARMACEUTICI S.p.A
    Inventors: Giovanni Gennari, Giampaolo Menon, Susi Panfilo
  • PROCESS FOR THE PRODUCTION OF HYALURONIC ACID IN ESCHERICHIA COLI OR BACILLUS MEGATERIUM
    Publication number: 20160032337
    Abstract: A method of producing hyaluronic acid (HA) in Escherichia coli and Bacillus megaterium through episomal plasmid vectors wherein the gene is under the control of strong promoter T7, preferably under the control of strong promoter T7 of bacteriophage T7, and a system for the selection of stable bacterial strains producing high levels of hyaluronic acid, are provided.
    Type: Application
    Filed: October 15, 2015
    Publication date: February 4, 2016
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Vincenza CORSA, Alessandro NEGRO, Sonia BISICCHIA
  • PHOTOCROSSLINKED HYALURONIC ACID DERIVATIVES, AND THE PREPARATION PROCESS AND USE THEREOF
    Publication number: 20150367027
    Abstract: Disclosed are photocrosslinked hyaluronic acid (HA) derivatives consisting of HA, a bifunctional polyethylene glycol (PEG) spacer which is triethylene glycol, and a photoreactive compound selected from a coumarin derivative and propiophenone.
    Type: Application
    Filed: February 4, 2014
    Publication date: December 24, 2015
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Monica CAMPISI, Ottorino DE LUCCHI, Riccardo BENINATTO, Giuseppe BORSATO
  • Process for the production of hyaluronic acid in or
    Patent number: 9163270
    Abstract: A method of producing hyaluronic acid (HA) in Escherichia coli and Bacillus megaterium through episomal plasmid vectors wherein the gene is under the control of strong promoter T7, preferably under the control of strong promoter T7 of bacteriophage T7, and a system for the selection of stable bacterial strains producing high levels of hyaluronic acid, are provided.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: October 20, 2015
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Vincenza Corsa, Alessandro Negro, Sonia Bisicchia
  • NEW RELEASE SYSTEM OF HYDROPHOBIC PROTEINS
    Publication number: 20150290326
    Abstract: The object of the present invention is novel release systems comprising specific hyaluronic acid amides combined with therapeutically and/or biologically active proteins with a mainly hydrophobic nature, for sustained, slow release over time which increases the efficacy of the medicament and the patient's compliance.
    Type: Application
    Filed: May 30, 2013
    Publication date: October 15, 2015
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Monica Campisi, Cristian Guarise, Davide Renier
  • Process for the synthesis of conjugates of glycosaminoglycanes (GAG) with biologically active molecules, polymeric conjugates and relative uses thereof
    Patent number: 9034624
    Abstract: The present invention relates to a process for the synthesis of conjugates of glycosaminoglycanes (GAG) with biologically active molecules of varying nature, comprising small molecules and macro-molecules. In particular, the present invention relates to the conjugation of hyaluronic acid (HA) and its derivatives with polypeptides and proteins with a biological action, such as, for example, interferons, erythropoietins, growth factors, insulin, cytokines, antibodies and hormones. An object of the present invention also relates to isolatable intermediates obtained by the partial or total reaction of GAG with protected amino aldehydes in the conjugation process mentioned above.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: May 19, 2015
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Matteo D'Este, Davide Renier, Gianfranco Pasut, Antonio Rosato
  • Absorbent dressings with painkilling activity
    Patent number: 8992890
    Abstract: The invention discloses pharmaceutical compositions in the form of a dusting powder or dry spray, possessing a high absorbent capacity, painkilling activity and wound-healing action, which compositions consist of croscarmellose sodium, a non-steroidal anti-inflammatory drug (NSAID) and hyaluronic acid, and optionally also contain other pharmacologically active substances and/or excipients. The compositions disclosed herein are suitable for use in the treatment of skin lesions wherein the presence of exudate limits wound healing and causes pain; they are therefore particularly suitable for chronic ulcerous skin lesions of various origins and burns.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: March 31, 2015
    Assignee: Fidia Farmaceutici S.p.A.
    Inventors: Andrea Pastorello, Devis Galesso, Fabio Bettella
  • PHARMACEUTICAL FORMULATIONS COMPRISING CHONDROITIN SULFATE AND HYALURONIC ACID DERIVATIVES
    Publication number: 20150072954
    Abstract: The present invention relates to pharmaceutical formulations containing a combination of specific high-molecular weight hyaluronic acid derivatives and chondroitin sulfate to be used in the treatment of osteoarthritis, of subchondral damage, osteoporosis, synovitis, tenosynovitis, tendinitis, tendinosis, as an intra-articular washing liquid and as a viscous substitute of synovial fluid following osteochondral surgery. These formulations are also suitable for the treatment of interstitial cystitis.
    Type: Application
    Filed: March 27, 2013
    Publication date: March 12, 2015
    Applicant: FIDIA FARMACEUTICI S.p.A.
    Inventors: Anna Maria Zanellato, Vincenza Corsa, Giancarlo Carpanese, Monica Campisi
  • Hyaluronic acid derivatives containing groups able to release NO
    Patent number: 8969320
    Abstract: Disclosed are hyaluronic acid derivatives functionalized with S-nitrosothiol groups of the general formula: wherein HA indicates hyaluronic acid and G indicates a suitable spacer.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: March 3, 2015
    Assignee: Fidia Farmaceutici S.p.A.
    Inventors: Davide Renier, Matteo D'Este
  • NEW PROCESS FOR THE PRODUCTION AND PURIFICATION OF THE COLLAGENASE ENZYME FROM VIBRIO ALGINOLYTICUS
    Publication number: 20150056179
    Abstract: The present invention claims a novel process for the production and purification of microbial collagenase (Microbial Collagenase EC 3.4.24.3) produced by the non-pathogenic aerobic bacterium Vibrio alginolyticus chemovar. iophagus (NCIMB Number: 1 1038, synonym LMG 3418, hereinafter called Vibrio alginolyticus), which said process provides high production levels of collagenase with a stable, reproducible, cheap fermentation process. The collagenase produced from Vibrio alginolyticus according to the process described herein also presents a specific activity superior to that of other microbial collagenases, is stable in aqueous solution, and can be frozen without significant damage.
    Type: Application
    Filed: April 17, 2013
    Publication date: February 26, 2015
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Susanna Vaccaro, Michele Caputo, Christian Cuppari, Giovanni Gennari
  • PHARMACEUTICAL COMPOSITIONS CONTAINING PHOSPHATIDYLSERINE AND CURCUMIN
    Publication number: 20150038467
    Abstract: The present invention describes and claims stable pharmaceutical compositions and/or food supplements based on phosphatidylserine (PS) and curcumin, which are consequently devoid of degradation products, for use in the prevention and treatment of disorders associated with brain aging, and in the prevention and treatment of osteoporosis and/or osteoarthritis.
    Type: Application
    Filed: January 23, 2013
    Publication date: February 5, 2015
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Giovanni Gennari, Susi Panfilo
  • NEW PHARMACEUTICAL COMPOSITIONS CONTAINING HYALURONIC ACID AND COLLAGENASE FOR THE TOPICAL TREATMENT OF WOUNDS, BURNS AND ULCERS
    Publication number: 20140377249
    Abstract: The present invention concerns new compositions containing hyaluronic acid or the derivatives thereof in association with the proteolytic enzyme collagenase (and relative pharmaceutical formulations) for the preparation of a dressing for topical treatment of various kinds of wounds, burns of varying depth, pressure sores, vascular ulcers and diabetic foot ulcers as well as for the treatment of hypertrophic and keloid scars.
    Type: Application
    Filed: September 9, 2014
    Publication date: December 25, 2014
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Susanna VACCARO, Giovanni GENNARI, Lanfranco CALLEGARO, Antonio GIANNELLI, Salvatore CARUSO
  • Pharmaceutical compositions containing hyaluronic acid and collagenase for the topical treatment of wounds, burns and ulcers
    Patent number: 8900576
    Abstract: The present invention concerns new compositions containing hyaluronic acid or the derivatives thereof in association with the proteolytic enzyme collagenase (and relative pharmaceutical formulations) for the preparation of a dressing for topical treatment of various kinds of wounds, burns of varying depth, pressure sores, vascular ulcers and diabetic foot ulcers as well as for the treatment of hypertrophic and keloid scars.
    Type: Grant
    Filed: July 5, 2006
    Date of Patent: December 2, 2014
    Assignee: Fidia Farmaceutici S.p.A
    Inventors: Susanna Vaccaro, Giovanni Gennari, Lanfranco Callegaro, Antonio Giannelli, Salvatore Caruso