Abstract: A composition for preventing the aggregation of platelets comprising, as an essential ingredient thereof, 8-bromo- or 8-chloro-3-(.beta.-diethylaminoethyl)-4-methyl-7-ethoxycarbonylmethoxycoum arin, and the use thereof.
Abstract: A method of treating arrhythmia in mammals which comprises administering 8-chloro- or 8-bromo-3-(.beta.-diethylaminoethyl)-4-methyl-7-ethoxycarbonylmethoxycouma rin (or a pharmaceutically acceptable salt thereof) thereto. When formulated in conventional pharmaceutical preparations, the active ingredient may be administered orally or endovenously.
Abstract: A selective process is described for producing monohalogenated derivatives of 7-hydroxy coumarin wherein the halo substituent is at the desired position and the final product is free of other monohalogenated isomers. The resulting products, especially those wherein the halo substituent is at the 8 position, have valuable specific coronary vasodilating activity.
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