Abstract: Systems and methods for collecting and processing livestock waste to facilitate the reclamation of water used in such processes and likewise produce fertilizer/soil amendments. Animal waste is initially collected, mixed with water and sequentially processed whereby large fibers present in the waste are separated, and the resultant manure sludge effluent. The manure sludge effluent may be treated with ultrasound, enzymatic pretreatment, aeration and/or polymers to promote coagulation and flocculation. A solids separation step is then performed to facilitate the separation of water and isolation of solids, the latter of which are formed into manure cakes and ultimately fertilizer/soil amendment products. The separated water is purified for reuse while further generating a nutrient concentrate.