Abstract: The invention relates to processes for the preparation of compounds of the formula
wherein R is a 2-piperidyl or 2-pyridyl radical, and pharmaceutically acceptable salts thereof, the process comprising the steps of:
a) reacting 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid or a salt thereof with a haloacetonitrile to form a cyanomethyl ester of formula
b) reacting the ester with an amine of the formula RCH2NH2, where R is as defined above.
Type:
Grant
Filed:
April 3, 2000
Date of Patent:
March 25, 2003
Assignee:
FineTech Ltd.
Inventors:
Arie L. Gutman, Genady Nisnevich, Eleonora Shkolnik, Igor Zaltzman
Abstract: A process for the preparation of trifluoroethoxy benzoic acid derivatives, in particular Flecainide, and their pharmaceutically acceptable salts, starting with commercially available halobenzoic acids and involving the use of simple reagents and low cost solvents, to afford high overall yield of the product.
Type:
Application
Filed:
July 23, 2001
Publication date:
September 19, 2002
Applicant:
FineTech Ltd.
Inventors:
Arie L. Gutman, Genady Nisnevich, Eleonora Shkolnik, Igor Zaltzman, Boris Tishin
Abstract: A process for producing trifluoroethoxybenzoic acids or salts thereof by reaction of halobenzoic acids or salts thereof with 2,2,2-trifluoroethanol in the presence of a strong base and copper containing materials. The compounds obtained by the process of the present invention may be used as synthetic intermediates in the pharmaceutical industry.
Type:
Grant
Filed:
January 18, 2000
Date of Patent:
September 11, 2001
Assignee:
FineTech, LTD
Inventors:
Arie L. Gutman, Genady Nisnevich, Eleonora Shkolnik, Igor Zaltzman
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