Abstract: A process for the preparation of trifluoroethoxy benzoic acid derivatives, in particular Flecainide, and their pharmaceutically acceptable salts, starting with commercially available halobenzoic acids and involving the use of simple reagents and low cost solvents, to afford high overall yield of the product.
Type:
Application
Filed:
July 23, 2001
Publication date:
September 19, 2002
Applicant:
FineTech Ltd.
Inventors:
Arie L. Gutman, Genady Nisnevich, Eleonora Shkolnik, Igor Zaltzman, Boris Tishin
Abstract: A process for producing trifluoroethoxybenzoic acids or salts thereof by reaction of halobenzoic acids or salts thereof with 2,2,2-trifluoroethanol in the presence of a strong base and copper containing materials. The compounds obtained by the process of the present invention may be used as synthetic intermediates in the pharmaceutical industry.
Type:
Grant
Filed:
January 18, 2000
Date of Patent:
September 11, 2001
Assignee:
FineTech, LTD
Inventors:
Arie L. Gutman, Genady Nisnevich, Eleonora Shkolnik, Igor Zaltzman