Abstract: Machine used for folding, profiling and cutting metal sheets includes a fixed support structure (1) holding a lower presser element (3), on which the sheet (4) rests, and an associated upper mobile presser element (5). Together, the presser elements (3, 5) keep the sheet (4) pressed in a proper horizontal plane. The machine further includes a mobile structure (7) having a C-shaped cross section which defines a channel (2) of longitudinal orientation. This C-shaped structure holds a pair of holding blades (8-9) which perform the folding of the sheet (4) when the same C-shaped structure is raised and lowered or made to advance or withdraw with respect to the sheet (4). In the interior of the channel (2) at least one removable tool holding group (10-11) is situated. This permits repositioning of the tool holding group along the longitudinal course of the channel (2).