Abstract: A desiccant cartridge (10) having a seal (12) therearound for forming a proper seal between cartridge (10) and canister (14) of a receiver/dryer or accumulator assembly includes a cup (16) extending along an axis (18) having inner wall portion (20) and outer wall portion (22) connected to transverse portion (24) to define a chamber (26) containing desiccant particles (30). Cap (70) is secured to cup (16) to secure the desiccant particles (30) inside chamber (26). Outer wall portion (22) is provided with the seal (12) that is composed of a flexible thermoplastic elastomer that is resistant to heat during welding shut of the canister (14).