Abstract: The present invention relates to a synthesis method of preventing the formation of impurities and byproducts in the synthesis of tenofovir disoproxil fumarate (Teno-DF) used as a medicine for hepatitis B and HIV treatment due to its function to promote bioactivities. In the synthesis method of the present invention, an ion-exchange resin (Dowex 50W hydrogen form, sulfonic acidic cation exchange resin) is used to enhance the yield and purity of the compound. The present invention also relates to a method of preparing an oral dissolving film dosage form in the manufacture of a medicine using the tenofovir compound with high purity obtained by the synthesis method of the present invention as an effective ingredient.
Type:
Grant
Filed:
May 19, 2015
Date of Patent:
December 18, 2018
Assignee:
FIRSON
Inventors:
Dong-Jin Kim, Chang-Hui Koo, Il-Hee Cho, Sung-Bae Lee, Dong-Hoon Han
Abstract: The present invention relates to a synthesis method of preventing the formation of impurities and byproducts in the synthesis of tenofovir disoproxil fumarate (Teno-DF) used as a medicine for hepatitis B and HIV treatment due to its function to promote bioactivities. In the synthesis method of the present invention, an ion-exchange resin (Dowex 50W hydrogen form, sulfonic acidic cation exchange resin) is used to enhance the yield and purity of the compound. The present invention also relates to a method of preparing an oral dissolving film dosage form in the manufacture of a medicine using the tenofovir compound with high purity obtained by the synthesis method of the present invention as an effective ingredient.
Type:
Application
Filed:
May 19, 2015
Publication date:
December 14, 2017
Applicant:
FIRSON
Inventors:
Dong-Jin Kim, Chang-Hui Koo, II-Hee Cho, Sung-Bae Lee, Dong-Hoon Han