Patents Assigned to First Tech International Limited
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Patent number: 10874635Abstract: Vitamin E compositions, methods of making such compositions and therapeutic uses of vitamin E compositions are disclosed. Compositions of matter comprising a tocotrienol making up at least 15 dry basis weight percent of the composition of matter and a constituent selected from a triglyceride and a triglyceride ester, wherein upon mixing of the composition of matter with water the tocotrienol based composition is substantially emulsified; and wherein upon mixing of the composition of matter with water a resulting emulsion has an intensity-weighed mean droplet size of less than 700 nm are also disclosed.Type: GrantFiled: October 19, 2012Date of Patent: December 29, 2020Assignee: First Tech International LimitedInventors: Sami Mahmoud Nazzal, Paul W. Sylvester, Alaadin Y. Alayoubi
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Patent number: 9180113Abstract: Compositions containing tocotrienol, non-tocotrienol lipids and surface active agents; compositions containing particles having a statin and a tocotrienol wherein the particle size is less than 1000 nm; and microemulsions containing a statin and a tocotrienol are disclosed. Methods relating to the creation of such compositions and the use of such compositions are further disclosed.Type: GrantFiled: September 1, 2010Date of Patent: November 10, 2015Assignee: First Tech International LimitedInventors: Sami Mahmoud Nazzal, Paul W. Sylvester
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Patent number: 9115145Abstract: Compositions of matter including (R)-2,5,6,8-tetramethyl-8-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)-1,2,3,8,9,10-hexahydrochromeno[5,6-e][1,3]oxazine and (R)-2,6,8-trimethyl-8-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)-1,2,3,8,9,10-hexahydrochromeno[5,6-e][1,3]oxazine are disclosed herein. Further disclosed are methods of preparation of such compounds and the use of such compounds as anticancer agents.Type: GrantFiled: July 21, 2014Date of Patent: August 25, 2015Assignee: FIRST TECH INTERNATIONAL LIMITEDInventors: Khalid A. El Sayed, Paul W. Sylvester, Fathy A. Behery
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Patent number: 8969303Abstract: Esters of tocotrienols having pharmacological activities pertinent to the treatment of breast cancer and other forms of cancer are disclosed herein. Among those compounds is (Z)-4-oxo-4-((R)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)chroman-6-yloxy)but-2-enoic acid. Tocotrienol esters were used to inhibit the growth and migration of +SA mammary epithelial cells and highly metastatic human breast cancer MDA-MB-231 cells respectively.Type: GrantFiled: February 4, 2011Date of Patent: March 3, 2015Assignee: First Tech International LimitedInventors: Khalid A. El Sayed, Paul W. Sylvester
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Patent number: 8816071Abstract: Compositions of matter including (R)-2,5,6,8-tetramethyl-8-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)-1,2,3,8,9,10-hexahydrochromeno[5,6-e][1,3]oxazine and (R)-2,6,8-trimethyl-8-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)-1,2,3,8,9,10-hexahydrochromeno[5,6-e][1,3]oxazine are disclosed herein. Further disclosed are methods of preparation of such compounds and the use of such compounds as anticancer agents.Type: GrantFiled: November 30, 2012Date of Patent: August 26, 2014Assignee: First Tech International LimitedInventors: Khalid A. El Sayed, Paul W. Sylvester, Fathy A. Behery
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Patent number: 8268786Abstract: Compounds are disclosed relating to the treatment of cancer that include tocotrienols and derivatives of tocotrienols including 2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)chroman-6-ylphenylsulfonylcarbamate; (R)-2,8-dimethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)chroman-6-yl tosylcarbamate; and (R)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)chroman-6-yl benzylcarbamate. Therapeutic uses of these types of compounds are also taught.Type: GrantFiled: April 23, 2010Date of Patent: September 18, 2012Assignee: First Tech International LimitedInventors: Paul W. Sylvester, Khalid A. El Sayed
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Publication number: 20110052704Abstract: Compositions containing tocotrienol, non-tocotrienol lipids and surface active agents; compositions containing particles having a statin and a tocotrienol wherein the particle size is less than 1000 nm; and microemulsions containing a statin and a tocotrienol are disclosed. Methods relating to the creation of such compositions and the use of such compositions are further disclosed.Type: ApplicationFiled: September 1, 2010Publication date: March 3, 2011Applicant: First Tech International LimitedInventors: Sami Mahmoud Nazzal, Paul W. Sylvester
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Publication number: 20100273869Abstract: Compounds are disclosed relating to the treatment of cancer that include tocotrienols and derivatives of tocotrienols including 2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)chroman-6-ylphenylsulfonylcarbamate; (R)-2,8-dimethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)chroman-6-yl tosylcarbamate; and (R)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)chroman-6-yl benzylcarbamate. Therapeutic uses of these types of compounds are also taught.Type: ApplicationFiled: April 23, 2010Publication date: October 28, 2010Applicant: FIRST TECH INTERNATIONAL LIMITEDInventors: Paul W. Sylvester, Khalid A. El Sayed