Abstract: A peristaltic pumping mechanism comprises a pump housing for holding a peristaltic drive means and adapted to support the drive motor for the peristaltic means. The mechanism further comprises a base member formed with an orifice having a periphery with a plurality of protrusions positioned therealong. The base member receives the housing in the orifice with a lip on the housing resting on the protrusions. The mechanism further comprises a cover which has an edge and a plurality of grips positioned along its edge for insertion between the periphery of the orifice and the lip of the housing to engage the grips with the base member and clampingly hold the housing and its associated peristaltic mechanism between the cover and the base member.