Abstract: Pressurized aerosol composition for administration by inhalation comprising a liquefied hydrofluoroalkane, a powdered medicament dispersed therein, and a suspending agent comprising a polymer soluble in the liquefied hydrofluoroalkane which is selected from polymers including recurring amide containing structural units, copolymers of amide containing units and carboxylic acid ester units, polyvinylacetate and acrylic acid/methacrylic acid ester copolymers.
Abstract: A new technique for combating helminthic parasites in an animal, e.g. a sheep or cow, comprises applying to the skin of the animal an anthelmintic amount of an anthelmintic compound, e.g. 4,5,6-trichloro-7-(diethylsulphamoyl)-2-(trifluoromethyl) benzimidazole, tetramisole or levamisole, whereby the compound is absorbed by the animal through its skin.
Abstract: There are provided compounds of formula I, ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.7 may be the same or different, and are hydrogen, hydroxy, alkoxy, alkoxy substituted by phenyl, acyl, amino, acylamino, alkenyl, halogen, or alkyl, provided that at least one of R.sup.1, R.sup.2, R.sup.3 and R.sup.7 are other than hydrogen and hydroxy,Or an adjacent pair of R.sup.1, R.sup.2, R.sup.3 and R.sup.7 represent a chain --COCH.dbd.CH--O--,X is a hydrocarbon chain containing from 2 to 10 carbon atoms and optionally substituted by a hydroxy group, andE is a carboxy group or a 5-tetrazolyl group, and pharmaceutically acceptable derivatives thereof.The compounds are indicated for use as antagonists of SRS-A.
Type:
Grant
Filed:
September 20, 1976
Date of Patent:
January 9, 1979
Assignee:
Fisons, Ltd.
Inventors:
Joachim Augstein, David Carter, Thomas B. Lee
Abstract: 2-Trifluoromethylbenzimidazoles having a sulphamoyl or substituted sulphamoyl substituent on the benzene ring combat mammalian parasites, for example liver fluke in mammals e.g. sheep, and cattle tick and sheep blowfly.