Abstract: A pharmaceutical composition for treating cancer, containing a crRNA and an endonuclease as active ingredients is disclosed. The composition can be customized according to the needs of patients or cell types by specifically treating cancer cells on the basis of specific binding properties of DNA and RNA. The nuclease activity of a CRISPR PLUS system, containing both an endonuclease and an exonuclease can be activated by means of the binding between crRNA and a gene specifically found in cancer cells. Therefore, the cancer treatment effect of the composition is more specific than that of other anti-cancer agents that have been developed up till now.

Abstract: A novel CRISPR-associated protein and a use thereof are disclosed. A protein of the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 3 exhibits the activity of endonucleases, which recognize and cleave an intracellular nucleic acid sequence linked to a guide RNA. Therefore, a novel CRISPR-associated protein can be used as a different nuclease for genome editing, in a CRISPR-Cas system.

Abstract: A system includes: a thermo-hygrostat provided in a room of a closed plant factory; a CO2 supply device supplying CO2 to the room; an outdoor air damper controlling a flow rate of an outdoor air introduced into the room; an exhaust damper controlling a flow rate of an indoor air discharged from the room; an air supply fan blowing the outdoor air introduced into the outdoor air damper; an exhaust fan blowing the indoor air discharged through the exhaust damper; an inducing fan provided on a ceiling of the room; an outdoor air sensor unit including an outdoor air temperature sensor, an outdoor air humidity sensor and an outdoor air CO2 sensor; an indoor sensor unit including an indoor temperature sensor, an indoor humidity sensor and an indoor CO2 sensor; a human body detection sensor; and a control unit.

Abstract: A system for controlling an environment of an air conditioner-type closed plant factory includes: an outdoor air damper installed in an air supply duct; an exhaust damper installed in an exhaust duct; a circulating air damper installed in a connection duct for connecting the air supply duct and the exhaust duct; a CO2 supply device supplying CO2 to the air introduced into the room; a humidification coil humidifying the air introduced into the room; a cold and hot water coil heating or cooling the air introduced into the room; an outdoor air sensor unit including an outdoor air temperature sensor, an outdoor air humidity sensor, and an outdoor air CO2 sensor; an indoor sensor unit including an indoor temperature sensor, an indoor humidity sensor, and an indoor CO2 sensor; a human body detection sensor detecting a human body in the room; and a control unit.

Abstract: A pharmaceutical composition for treating cancer, containing a crRNA and an endonuclease as active ingredients is disclosed. The composition can be customized according to the needs of patients or cell types by specifically treating cancer cells on the basis of specific binding properties of DNA and RNA. The nuclease activity of a CRISPR PLUS system, containing both an endonuclease and an exonuclease can be activated by means of the binding between crRNA and a gene specifically found in cancer cells. Therefore, the cancer treatment effect of the composition is more specific than that of other anti-cancer agents that have been developed up till now.

Abstract: A foot splint for the prevention and rehabilitation of plantar fasciitis by maintaining a wearer's foot and, hence, his plantar fascia in a pre-selected amount of dorsiflexion. The foot splint includes a footplate for supporting the wearer's foot, a bracket integrally attached to the footplate near the heel region, where the bracket has at least one ankle angle preset, a strut (either medial, lateral, or both sides) extending along the lower leg of the wearer, a strut sleeve removably enveloping the strut. The sleeve has an upper end and a lower end, and the strut protrudes from the lower end of the sleeves. There is an adjustable leg strap attached to the strut sleeve at the upper end. The strap secures the upper end to the leg of a wearer during operation. A padded insole may be provided to cushion the wearer's foot from the footplate. The foot splint provides a comfortable “slipper-like” feel for the wearer.

Abstract: A foot splint for the prevention and rehabilitation of plantar fasciitis by maintaining a wearer's foot and, hence, his plantar fascia, in a preselected amount of dorsiflexion. The foot splint includes a footplate for supporting the wearer's foot, a lateral strut extending along the lower leg of the wearer and having a strap for releaseably attaching the strut to the wearer's leg, and a wrap for wrapping around the foot of the wearer. A soft insole may be provided to cushion the wearer's foot from the footplate. The wrap, insole and footplate provide a comfortable “slipper-like” feel for the wearer. Moreover, the foot splint is particularly suited for use during sleep since it is light-weight and open configuration allows for the wearer to move unimpeded between sleep positions, resulting in a more restful sleep. Moreover, the lateral placement of the strut keeps the rigid portions of the foot splint from inadvertently abrading, striking, or otherwise interfering with the wearer's other leg.

Abstract: The invention is a disposable liner for an AFO/contracture foot splint that is sufficiently soft and flexible so as to comfortably conform to body surfaces and provide a substantially close fit to prevent leakage. The liner has a fluid permeable layer, an absorbent layer, and a moisture-proof layer which is a liquid impervious back sheet disposed on the outer surface of the liner. The liner has a toe end, a foot region, a leg end, a leg region and a heel region. The foot region has winged extensions terminated with fastening elements for securing the foot region. The leg end of the liner has tabular extensions terminated with re-closable fastening elements for securing the leg region of the disposable liner to the leg. The heel region of the liner has an opening, which enables a portion of the wearer's heel to project through the heel region into heel “well” of a splint.

Abstract: A universal carpal tunnel device for supporting the hand in a neutral position to alleviate and prevent the carpal tunnel syndrome. The device includes a pad for placement against a wearer, a base attached to the pad, a stay disposed between the pad and base, and an adjustment strap for attaching the device to the wearer. The pad or the base can be provided with a recessed channel for receiving the stay. The pad, base and stay form a palmar section of the device which extends over the heel of the hand and terminates prior to the palmar fold of the hand so to not unnecessarily restrict movement of the wearer's hand and digits, and a main section for engaging the forearm of the wearer. The palmar section also has a sufficient width for preventing opposition between the thumb and the fifth digit of the hand. The device laterally has first and second sides which are mirror images of each other so that the carpal tunnel device can be used on either the right or left hand.

Abstract: An attachment device (1) secures an enclosure to the roof frame (2) of a golf cart has a sleeve portion which wraps around the frame (2) and is secured by zipper teeth (9). An optional flap (14 15) extending from the sleeve portion has attachment means to secure an enclosure. Opening slots (13) in the flap allow windshield opening release brackets (7) to be inserted therethrough.