Patents Assigned to FLAGSHIP PIONEERING INNOVATIONS VI, LLC
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Patent number: 11987616Abstract: The invention provides, in various embodiments, polypeptides (e.g., camelid antibodies and antigen binding fragments thereof) that specifically bind to Spike glycoprotein of severe acute respiratory syndrome coronavirus (e.g., SARS-CoV-2-Spike). The invention also provides, in various embodiments, fusion proteins comprising one or more of the polypeptides, polynucleotides encoding the polypeptides, vectors and host cells suitable for expressing the polypeptides, and methods for treating viral infections (e.g., COVID-19).Type: GrantFiled: February 15, 2023Date of Patent: May 21, 2024Assignee: Flagship Pioneering Innovations VI, LLCInventors: Gevorg Grigoryan, John Ingraham
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Patent number: 11981725Abstract: The invention provides, in various embodiments, polypeptides that specifically bind to Spike glycoprotein of severe acute respiratory syndrome coronavirus (e.g., SARS-CoV-2-Spike). The invention also provides, in various embodiments, fusion proteins comprising one or more of the polypeptides, polynucleotides encoding the polypeptides, vectors and host cells suitable for expressing the polypeptides, and methods for treating viral infections (e.g., COVID-19).Type: GrantFiled: January 6, 2023Date of Patent: May 14, 2024Assignee: Flagship Pioneering Innovations VI, LLCInventors: Gevorg Grigoryan, John Ingraham, Cheuk Lun Leung, Ross Steven Federman, Robin Jeffrey Green, Alexis Hiram Ramos, Jenhan Tao
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Patent number: 11978538Abstract: Methods of associating a test compound with a compound property. One or more datasets including: for each of a plurality of cell lines and each of a plurality of compounds: for each respective exposure condition: a corresponding response signature for the respective compound in the respective cell line under the respective exposure condition is obtained. A correlation is determined for each unique combination of exposure conditions for a respective pair of compounds based on the corresponding response signature. A weight is determined for each respective pair of compounds based on the determined correlations. A plurality of compound clusters is formed, where each cluster represents compounds that satisfy one or more weight criteria with respect to a particular compound. A compound property of the test compound is determined from properties of one or more compounds in a one or more compound clusters that contain the test compound.Type: GrantFiled: June 15, 2022Date of Patent: May 7, 2024Assignee: FLAGSHIP PIONEERING INNOVATIONS VI, LLCInventors: Fabian Alexander Wolf, Umut Eser, Nicholas McCartney Plugis
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Patent number: 11844759Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.Type: GrantFiled: November 16, 2022Date of Patent: December 19, 2023Assignee: Flagship Pioneering Innovations VI, LLCInventors: Avak Kahvejian, Alexandra Sophie De Boer, Nicholas McCartney Plugis, Erica Gabrielle Weinstein, Sebastian Trousil, Morag Helen Stewart, Ki Young Paek, Catherine Cifuentes-Rojas
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Patent number: 11827897Abstract: Disclosed herein are agricultural compositions comprising plant messenger packs (PMPs), methods for using the same, and methods and related bioreactors for manufacturing PMPs.Type: GrantFiled: September 9, 2021Date of Patent: November 28, 2023Assignee: Flagship Pioneering Innovations VI, LLCInventors: Maria Helena Christine Van Rooijen, Hok Hei Tam, Barry Andrew Martin, Daniel Garcia Cabanillas, Simon Schwizer, Nataliya Vladimirovna Nukolova, Yajie Niu
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Patent number: 11788152Abstract: Disclosed herein are methods, non-transitory computer readable media, systems, and kits for performing a multiple tiered analysis for identifying individuals with a health condition for monitoring, treating, and/or enrolling the individuals in a clinical trial. Specifically, the multiple tiered analysis involves a first screen, which eliminates a large proportion of individuals who are identified as not at risk for a health condition, and a subsequent second analysis which detects presence of a health condition in the remaining individuals. The second analysis includes an intra-individual analysis, which involves combining sequence information from target nucleic acids and reference nucleic acids obtained from the individual. The target nucleic acids include signatures that may be informative for determining presence or absence of the health condition and the reference nucleic acids include baseline biological signatures of the individual.Type: GrantFiled: August 29, 2022Date of Patent: October 17, 2023Assignee: Flagship Pioneering Innovations VI, LLCInventor: Anthony P. Shuber
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Publication number: 20230242867Abstract: The invention provides methods for manufacturing purified preparations of achromosomal dynamic active systems (ADAS), including highly active ADAS. These ADAS provided by the invention can be obtained by a variety of means. Various associated methods of making and using these ADAS are provided.Type: ApplicationFiled: June 17, 2021Publication date: August 3, 2023Applicant: Flagship Pioneering Innovations VI, LLCInventors: Adam Barclay FISHER, Troy Patrick HUBBARD, Caitlin Nicole SPAULDING, Maier Steve AvendaƱo AMADO
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Patent number: 11654121Abstract: The present disclosure relates to therapeutic agents and combinations thereof (e.g., pharmaceutical compositions) for the treatment of a viral infection in a subject, tissue or cell.Type: GrantFiled: August 1, 2022Date of Patent: May 23, 2023Assignee: Flagship Pioneering Innovations VI, LLCInventors: David Barry Kolesky, Michael Ka Chun Wong, Hok Hei Tam
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Patent number: 11458156Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.Type: GrantFiled: September 22, 2021Date of Patent: October 4, 2022Assignee: Flagship Pioneering Innovations VI, LLCInventors: Alexandra Sophie De Boer, Avak Kahvejian, Nicholas McCartney Plugis, Erica Gabrielle Weinstein, Sebastian Trousil, Morag Helen Stewart, Ki Young Paek, Catherine Cifuentes-Rojas
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Patent number: 11160822Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.Type: GrantFiled: May 6, 2021Date of Patent: November 2, 2021Assignee: FLAGSHIP PIONEERING INNOVATIONS VI, LLCInventors: Alexandra Sophie De Boer, Avak Kahvejian, Nicholas McCartney Plugis, Erica Gabrielle Weinstein, Sebastian Trousil, Morag Helen Stewart, Ki Young Paek, Catherine Cifuentes-Rojas
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Patent number: 11058706Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.Type: GrantFiled: February 11, 2021Date of Patent: July 13, 2021Assignee: FLAGSHIP PIONEERING INNOVATIONS VI, LLCInventors: Morag Helen Stewart, Catherine Cifuentes-Rojas, Ki Young Paek, Avak Kahvejian, Nicholas McCartney Plugis, Alexandra Sophie De Boer, Erica Gabrielle Weinstein, Sebastian Trousil
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Patent number: 10953033Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.Type: GrantFiled: June 11, 2019Date of Patent: March 23, 2021Assignee: FLAGSHIP PIONEERING INNOVATIONS VI, LLCInventors: Morag Helen Stewart, Catherine Cifuentes-Rojas, Ki Young Paek, Avak Kahvejian, Nicholas McCartney Plugis, Alexandra Sophie De Boer, Erica Gabrielle Weinstein, Sebastian Trousil