Patents Assigned to FLAGSHIP PIONEERING INNOVATIONS VI, LLC
  • Patent number: 12191023
    Abstract: Described herein are platforms for use in targeted therapy development for an individual or group of individuals. Targeted therapy development as described herein comprises developing a therapeutic or therapeutic modality that is specific to or customized to an individual or group of individuals.
    Type: Grant
    Filed: February 8, 2023
    Date of Patent: January 7, 2025
    Assignee: FLAGSHIP PIONEERING INNOVATIONS VI, LLC
    Inventors: Douglas Gowers Cole, Aaron Garth Day-Williams
  • Patent number: 12163142
    Abstract: Disclosed herein are methods, and related bioreactors, for manufacturing plant messenger packs (PMPs), which can be formulated for use in a variety of agricultural and therapeutic methods.
    Type: Grant
    Filed: August 24, 2019
    Date of Patent: December 10, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Maria Helena Christine Van Rooijen, Hok Hei Tam, Barry Andrew Martin, Daniel Garcia Cabanillas, Simon Schwizer, Nataliya Vladimirovna Nukolova, Yajie Niu
  • Patent number: 12157898
    Abstract: Methods and compositions for modulating a target genome are disclosed. This disclosure relates to novel compositions, systems and methods for altering a genome at one or more locations in a host cell, tissue or subject, in vivo or in vitro. In particular, the invention features compositions, systems and methods for inserting, altering, or deleting sequences of interest in a host genome.
    Type: Grant
    Filed: July 19, 2023
    Date of Patent: December 3, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Anne Helen Bothmer, Cecilia Giovanna Silvia Cotta-Ramusino, William Edward Salomon, Jacob Rosenblum Rubens, Robert James Citorik, Zi Jun Wang, Kyusik Kim, Randi Michelle Kotlar, Ananya Ray, Robert Charles Altshuler, Sandeep Kumar, Nathaniel Roquet, Barrett Ethan Steinberg
  • Patent number: 12121531
    Abstract: The invention relates generally to tRNA-based effector molecules having a non-naturally occurring modification and methods relating thereto.
    Type: Grant
    Filed: November 4, 2021
    Date of Patent: October 22, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Theonie Anastassiadis, David Charles Donnell Butler, Neil Kubica, Qingyi Li
  • Patent number: 12123034
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject.
    Type: Grant
    Filed: August 10, 2023
    Date of Patent: October 22, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Cecilia Giovanna Silvia Cotta-Ramusino, Randi Michelle Kotlar, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg
  • Patent number: 12110324
    Abstract: The disclosure provides, in various embodiments, polypeptides (e.g., antibodies and antigen binding fragments thereof) that specifically bind to a thymic stromal lymphopoietin (TSLP) (e.g., a full-length human TSLP). The disclosure also provides, in various embodiments, fusion proteins comprising one or more of the polypeptides, polynucleotides encoding the polypeptides, vectors and host cells suitable for expressing the polypeptides, and methods for treating a TSLP-associated disease or condition.
    Type: Grant
    Filed: July 21, 2023
    Date of Patent: October 8, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Antonios O. Aliprantis, Zachary Kohl Costello, Anthony John Coyle, Kristen Park Hopson, Ryan Terrell Phennicie, Alexis Hiram Ramos, Adam Reid Root, Lana Dinic, Karin Alma Frieda Reif
  • Patent number: 12065669
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: August 20, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Stephen Hoyt Cleaver, Barrett Ethan Steinberg, Jacob Rosenblum Rubens, Robert James Citorik, William Edward Salomon, Zi Jun Wang
  • Patent number: 12060578
    Abstract: Systems and methods for associating a compound with physiological conditions are provided. A fingerprint of a compound chemical structure is obtained and inputted to a model that outputs one or more calculated activation scores. Each activation score represents a cellular constituent module in a set of modules, where each module includes a subset of cellular constituents and a first module in the set of modules is associated with the physiological condition. When the activation score for the first module satisfies a threshold criterion, the compound is identified as associated with the physiological condition. In some aspects, each activation score represents a perturbation signature associated with the physiological condition and the compound is identified when the activation score for a first perturbation signature satisfies a threshold criterion. Systems and methods for training a model that associates compounds with physiological conditions are also provided.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: August 13, 2024
    Assignee: FLAGSHIP PIONEERING INNOVATIONS VI, LLC
    Inventors: Fabian Alexander Wolf, Ragy Haddad, Nicholas McCartney Plugis
  • Patent number: 12037602
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: July 16, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Stephen Hoyt Cleaver, Barrett Ethan Steinberg, Jacob Rosenblum Rubens, Robert James Citorik, William Edward Salomon, Zi Jun Wang
  • Patent number: 12037617
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject.
    Type: Grant
    Filed: August 10, 2023
    Date of Patent: July 16, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Cecilia Giovanna Silvia Cotta-Ramusino, Randi Michelle Kotlar, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg
  • Patent number: 12031162
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject.
    Type: Grant
    Filed: August 10, 2023
    Date of Patent: July 9, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Cecilia Giovanna Silvia Cotta-Ramusino, Randi Michelle Kotlar, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg
  • Patent number: 12031129
    Abstract: Methods and compositions for modulating a target genome are disclosed. The composition may comprise a first RNA encoding a polypeptide comprising a retrotransposase reverse transcriptase domain and a retrotransposase endonuclease domain. The composition may also comprise a second RNA comprising a sequence that binds the polypeptide and a heterologous object sequence. The composition may insert the sequence of the heterologous object sequence into a target DNA.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: July 9, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Jacob Rosenblum Rubens, Geoffrey A. von Maltzahn, Robert James Citorik, Barrett Ethan Steinberg, Donghui Li, William Edward Salomon
  • Patent number: 12024728
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject.
    Type: Grant
    Filed: July 20, 2023
    Date of Patent: July 2, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Cecilia Giovanna Silvia Cotta-Ramusino, Randi Michelle Kotlar, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg
  • Patent number: 12020776
    Abstract: Humanizing proteins can be a laborious process, often involving trial and error or other non-systematic methods. To improve humanization, neural networks can be employed to generate new protein sequences having higher probabilities of being humanized. In an embodiment, a method includes evaluating the immunogenicity of a sampling of protein sequences. The method can include weighting the sampling of protein sequences from the generative model according to an estimated probability of a particular generated protein sequence having a deviation in immunogenicity than a particular percentile of immunogenicity of the sampling of protein sequences. The method can further include generating a protein sequence weighted sampling of protein sequences. The generated protein sequence representing a protein has an altered immunogenicity. Such a generated protein has a higher likelihood of being humanized.
    Type: Grant
    Filed: October 27, 2022
    Date of Patent: June 25, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Kevin Kaichuang Yang, Jacob D. Feala, Maxim Baranov, Brinda Monian
  • Patent number: 11987616
    Abstract: The invention provides, in various embodiments, polypeptides (e.g., camelid antibodies and antigen binding fragments thereof) that specifically bind to Spike glycoprotein of severe acute respiratory syndrome coronavirus (e.g., SARS-CoV-2-Spike). The invention also provides, in various embodiments, fusion proteins comprising one or more of the polypeptides, polynucleotides encoding the polypeptides, vectors and host cells suitable for expressing the polypeptides, and methods for treating viral infections (e.g., COVID-19).
    Type: Grant
    Filed: February 15, 2023
    Date of Patent: May 21, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Gevorg Grigoryan, John Ingraham
  • Patent number: 11981725
    Abstract: The invention provides, in various embodiments, polypeptides that specifically bind to Spike glycoprotein of severe acute respiratory syndrome coronavirus (e.g., SARS-CoV-2-Spike). The invention also provides, in various embodiments, fusion proteins comprising one or more of the polypeptides, polynucleotides encoding the polypeptides, vectors and host cells suitable for expressing the polypeptides, and methods for treating viral infections (e.g., COVID-19).
    Type: Grant
    Filed: January 6, 2023
    Date of Patent: May 14, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Gevorg Grigoryan, John Ingraham, Cheuk Lun Leung, Ross Steven Federman, Robin Jeffrey Green, Alexis Hiram Ramos, Jenhan Tao
  • Patent number: 11978538
    Abstract: Methods of associating a test compound with a compound property. One or more datasets including: for each of a plurality of cell lines and each of a plurality of compounds: for each respective exposure condition: a corresponding response signature for the respective compound in the respective cell line under the respective exposure condition is obtained. A correlation is determined for each unique combination of exposure conditions for a respective pair of compounds based on the corresponding response signature. A weight is determined for each respective pair of compounds based on the determined correlations. A plurality of compound clusters is formed, where each cluster represents compounds that satisfy one or more weight criteria with respect to a particular compound. A compound property of the test compound is determined from properties of one or more compounds in a one or more compound clusters that contain the test compound.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: May 7, 2024
    Assignee: FLAGSHIP PIONEERING INNOVATIONS VI, LLC
    Inventors: Fabian Alexander Wolf, Umut Eser, Nicholas McCartney Plugis
  • Patent number: 11844759
    Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.
    Type: Grant
    Filed: November 16, 2022
    Date of Patent: December 19, 2023
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Avak Kahvejian, Alexandra Sophie De Boer, Nicholas McCartney Plugis, Erica Gabrielle Weinstein, Sebastian Trousil, Morag Helen Stewart, Ki Young Paek, Catherine Cifuentes-Rojas
  • Patent number: 11827897
    Abstract: Disclosed herein are agricultural compositions comprising plant messenger packs (PMPs), methods for using the same, and methods and related bioreactors for manufacturing PMPs.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: November 28, 2023
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Maria Helena Christine Van Rooijen, Hok Hei Tam, Barry Andrew Martin, Daniel Garcia Cabanillas, Simon Schwizer, Nataliya Vladimirovna Nukolova, Yajie Niu
  • Patent number: 11788152
    Abstract: Disclosed herein are methods, non-transitory computer readable media, systems, and kits for performing a multiple tiered analysis for identifying individuals with a health condition for monitoring, treating, and/or enrolling the individuals in a clinical trial. Specifically, the multiple tiered analysis involves a first screen, which eliminates a large proportion of individuals who are identified as not at risk for a health condition, and a subsequent second analysis which detects presence of a health condition in the remaining individuals. The second analysis includes an intra-individual analysis, which involves combining sequence information from target nucleic acids and reference nucleic acids obtained from the individual. The target nucleic acids include signatures that may be informative for determining presence or absence of the health condition and the reference nucleic acids include baseline biological signatures of the individual.
    Type: Grant
    Filed: August 29, 2022
    Date of Patent: October 17, 2023
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventor: Anthony P. Shuber