Abstract: The present invention relates to chemically modified, linked double-stranded (ds)RNA compositions comprising two or more double-stranded (ds) oligoribonucleotides linked by at least one linking moiety and methods of formulating and delivering such compositions to modulate gene expression through target-specific RNA co-interference (RNAco-i). The compositions of the invention may optionally comprise a conjugation or a complex with one or more small molecule drugs, protein therapeutics, or other dsRNA molecules. The present invention is directed at the methods of production for, methods of use of, and therapeutic utilities for RNAi co-interference therapy utilizing the compositions of the invention.
Type:
Application
Filed:
January 19, 2010
Publication date:
December 30, 2010
Applicant:
FLAGSHIP VENTURES
Inventors:
David Arthur Berry, Noubar Boghos Afeyan, Chris Varma
Abstract: The present invention relates to chemically modified, linked double-stranded (ds)RNA compositions comprising two or more double-stranded (ds) oligoribonucleotides linked by at least one linking moiety and methods of formulating and delivering such compositions to modulate gene expression through target-specific RNA co-interference (RNAco-i). The compositions of the invention may optionally comprise a conjugation or a complex with one or more small molecule drugs, protein therapeutics, or other dsRNA molecules. The present invention is directed at the methods of production for, methods of use of, and therapeutic utilities for RNAi co-interference therapy utilizing the compositions of the invention.
Type:
Application
Filed:
March 5, 2008
Publication date:
December 18, 2008
Applicant:
Flagship Ventures
Inventors:
David Arthur Berry, Noubar Boghes Afeyan, Chris Varma