Patents Assigned to Flamma S.p.A.
  • Peptide derivatives and therapeutic activity thereof
    Patent number: 11420943
    Abstract: Disclosed are peptide or pseudopeptide derivatives containing a nitrogenous heterocyclic residue with blocking activity against the by-products of lipid oxidative stress, and in particular of unsaturated aldehydes such as malondialdehyde and 4-hydroxy-trans-2-nonenal (HNE).
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: August 23, 2022
    Assignee: FLAMMA S.P.A.
    Inventors: GianPaolo Negrisoli, Stefania Gagliardi, Almin Silnovic, Clelia Dallanoce, Marco De Amici, Renato Canevotti
  • PEPTIDE DERIVATIVES AND THERAPEUTIC ACTIVITY THEREOF
    Publication number: 20200361875
    Abstract: Disclosed are peptide or pseudopeptide derivatives containing a nitrogenous heterocyclic residue with blocking activity against the by-products of lipid oxidative stress, and in particular of unsaturated aldehydes such as malondialdehyde and 4-hydroxy-trans-2-nonenal (HNE).
    Type: Application
    Filed: December 19, 2018
    Publication date: November 19, 2020
    Applicant: FLAMMA S.P.A.
    Inventors: GianPaolo NEGRISOLI, Stefania GAGLIARDI, Almin SILNOVIC, Clelia DALLANOCE, Marco DE AMICI, Renato CANEVOTTI
  • Process for preparing D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
    Patent number: 10125164
    Abstract: The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: November 13, 2018
    Assignee: FLAMMA S.P.A.
    Inventors: Xinjun Zhao, Minyu Zheng, Xiaozhong Yu, Hanrong Gao, Fabrice Cornille
  • Process for the production of D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
    Patent number: 10112976
    Abstract: The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: October 30, 2018
    Assignee: FLAMMA S.P.A.
    Inventors: Xinjun Zhao, Minyu Zheng, Xiaozhong Yu, Hanrong Gao, Fabrice Cornille
  • Peptide derivatives with therapeutic activity
    Patent number: 8765798
    Abstract: Dipeptide compounds containing a histidine residue proved to have interesting blocking activity on secondary products from lipid oxidative stress, in particular on unsaturated aldehydes such as malondialdehyde and hydroxynonenal, which are known to contribute to the inset of quite a number of chronic pathologies such as neurodegenerative, inflammatory chronic, cardiovascular diseases, diabetes complications and cataract.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: July 1, 2014
    Assignee: Flamma S.p.A.
    Inventors: Gianpaolo Negrisoli, Renato Canevotti
  • Amino alcohol derivatives and their therapeutic activities
    Patent number: 8623900
    Abstract: The present invention relates to amino alcohol derivatives of general formula I: These derivatives possess an interesting activity in that they block the secondary products of lipid oxidative stress, and are consequently suitable for therapeutic use in all disorders related with the presence of reactive carbonyl compounds.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: January 7, 2014
    Assignees: Flamma S.p.A., Universita degli Studi di Milano
    Inventors: Gianpaolo Negrisoli, Renato Canevotti, Massimo Previtali, Giancarlo Aldini, Marina Carini, Marica Orioli, Giulio Vistoli
  • AMINO ALCOHOL DERIVATIVES AND THEIR THERAPEUTIC ACTIVITIES
    Publication number: 20120316212
    Abstract: The present invention relates to amino alcohol derivatives of general formula I: These derivatives possess an interesting activity in that they block the secondary products of lipid oxidative stress, and are consequently suitable for therapeutic use in all disorders related with the presence of reactive carbonyl compounds.
    Type: Application
    Filed: December 20, 2010
    Publication date: December 13, 2012
    Applicants: UNIVERSITA DEGLI STUDI DI MILANO, FLAMMA S.P.A.
    Inventors: Gianpaolo Negrisoli, Renato Canevotti, Massimo Previtali, Giancarlo Aldini, Marina Carini, Marica Orioli, Giulio Vistoli
  • Pharmaceutical Formulations Comprising Active Pharmaceutical Principles Adsorbed on Titanium Dioxide Nanoparticles
    Publication number: 20080206347
    Abstract: The invention provides methods for the adsorption of an active pharmaceutical ingredient on titianium dioxide nanoparticles which can be orally ingested allowing the drug release into the intestine without causing side effects to the upper gastrointestinal region.
    Type: Application
    Filed: April 12, 2006
    Publication date: August 28, 2008
    Applicant: FLAMMA S.P.A.
    Inventors: Alberto Marra, Alessandro Dondoni, Carlo Alberto Bignozzi, Renato Canevotti, Negrisoli Gian Paolo, Valeria Dissette
  • Hydrosoluble organic salts of creatine
    Patent number: 5973199
    Abstract: Hydrosoluble organic salts of creatine are disclosed. The salts are useful in the dietetic and food industry.
    Type: Grant
    Filed: May 22, 1996
    Date of Patent: October 26, 1999
    Assignee: Flamma S.p.A.
    Inventors: Gianpaolo Negrisoli, Lucno Del Corona