Abstract: A computer-implemented system for identifying a patient for a trial may include at least one processor. The at least one processor may be programmed to receive an indication of a selected trial, the selected trial being associated with a testing status criterion; access a plurality of patient records associated with a patient of a plurality of patients; determine, using a machine learning model and based on unstructured information from one at least one of the patient records, a likelihood of an occurrence of genomic testing for the patient; determine a genomic testing status of the patient based on the determined likelihood of the occurrence of genomic testing; determine that the genomic testing status satisfies the testing status criterion; and include the patient in a subset of the plurality of patients based on the genomic testing status satisfying the testing status criterion.

Abstract: A model-assisted system for predicting survivability of a patient may include at least one processor. The processor may be programmed to access a database storing a medical record for the patient. The medical record may include at least one of structured and unstructured information relative to the patient and may lack a structured patient ECOG score. The processor may be further programmed to analyze at least one of the structured and unstructured information relative to the patient; based on the analysis, and in the absence of a structured ECOG score, generate a performance status prediction for the patient; and provide an output indicative of the predicted performance status. The analysis of at least one of the structured and unstructured information and the generation of the predicted performance status may be performed by at least one of a trained machine learning model or a natural language processing algorithm.

Abstract: A system for tracking adverse events may include at least one processing device programmed to receive a request from a user to record an adverse event experienced by a patient; receive a search term input by the user; identify, in an adverse event database and based on the search term, at least one database record for an adverse event, wherein the at least one database record includes an adverse event type and at least one characteristic; receive, via an input field, a rating of the at least one characteristic for the patient; generate an adverse event record based on the adverse event type and the rating; and store the adverse event record in an adverse event log.

Abstract: Described herein are techniques of using machine learning to automatically extract clinical variable values for subjects from clinical record data. The techniques designate certain clinical variables as hybrid variables that can be assigned values by machine learning model prediction. The techniques process, using a machine learning model trained to predict a value of a hybrid variable, clinical record data associated with a subject to obtain a predicted hybrid variable value and an associated confidence score. The techniques set the value of the hybrid variable for the subject to the predicted hybrid variable value when the model prediction is of sufficiently high confidence.

Abstract: A model-assisted system for extracting patient information. A processor may be programmed to access a database storing one or more medical records associated with a patient and determine, using a first machine learning model and based on unstructured information included in the one or more medical records, whether the patient is associated with a condition. The processor may further be programmed to identify a date associated with the patient and determine, using a second machine learning model and based on the unstructured information, whether the patient is associated with the condition relative to the date. The processor may generate an output indicating whether the patient is associated with the condition and whether the patient is associated with the condition relative to the date.

Abstract: Described herein are techniques of using machine learning to automatically extract clinical variable values for subjects from clinical record data. The techniques designate certain clinical variables as hybrid variables that can be assigned values by machine learning model prediction. The techniques process, using a machine learning model trained to predict a value of a hybrid variable, clinical record data associated with a subject to obtain a predicted hybrid variable value and an associated confidence score. The techniques set the value of the hybrid variable for the subject to the predicted hybrid variable value when the model prediction is of sufficiently high confidence.

Abstract: Methods and systems for interacting with and/or managing a clinical trial protocol via an electronic clinical trial protocol management system. The electronic clinical trial protocol management system capable of handling one or more treatment cycles within the clinical trial protocol, and having one or more occurrence programmatic elements and one or more treatment cycle programmatic elements. Each occurrence programmatic element includes a formulaic representation of scheduling of a clinical procedure within one or more treatment cycles. Procedure programmatic elements are related to one or more iterations of a treatment cycle programmatic element. Via such a relationship it is possible to determine a proper clinical procedure applicable to a subject at a position in a clinical trial using an occurrence programmatic element.

Abstract: Systems and methods are disclosed for monitoring models for bias. In one implementation, a system for automatically assessing a deployed model for selection of a cohort may include a processing device programmed to: apply the deployed model to data representing a first plurality of individuals, the data including at least one characteristic of the first plurality of individuals; based on the application, select a subset of the first plurality of individuals as a cohort; receive data representing a second plurality of individuals labeled as within the cohort, the data including the at least one characteristic of the second plurality of individuals; compare the selected subset and the second plurality of individuals along the at least one characteristic; and determine whether the comparison results in a difference between the selected subset and the second plurality of individuals greater than a threshold.

Abstract: A model-assisted system for determining a patient event date may include a processor. The processor may be programmed to access a database storing a medical record associated with a patient, the medical record comprising unstructured data; analyze the unstructured data to identify a plurality of snippets of information in the medical record associated with a patient event; determine a date associated with each of the plurality of snippets, identify a plurality of query periods associated with the patient event; and generate, for each of the query periods, a probability of whether the patient event occurred during the query period based on the plurality of snippets and the associated dates.

Abstract: A model-assisted system for determining probabilities associated with a patient attribute. The processor may be programmed to access a database storing an unstructured medical record associated with a patient and analyze the medical record to identify snippets of information associated with the patient attribute. The processor may generate, based on each snippet, a snippet vector comprising a plurality of snippet vector elements comprising weight values associated with at least one word included in the snippet. The processor may analyze the snippet vectors to generate a summary vector comprising a plurality of summary vector elements, wherein each of the plurality of summary vector elements is associated with a corresponding snippet vector element and is determined based on an analysis of the corresponding snippet vector element. The processor may further generate, based on the summary vector, at least one output indicative of a probability associated with the patient attribute.

Abstract: A system for tracking adverse events may include at least one processing device programmed to receive a request from a user to record an adverse event experienced by a patient; receive a search term input by the user; identify, in an adverse event database and based on the search term, at least one database record for an adverse event, wherein the at least one database record includes an adverse event type and at least one characteristic; receive, via an input field, a rating of the at least one characteristic for the patient; generate an adverse event record based on the adverse event type and the rating; and store the adverse event record in an adverse event log.

Abstract: Systems and methods may manage one or more clinical trials. In one implementation, a system for creating a query for a trial includes at least one processor programmed to: cause a computing device associated with a sponsor of the trial to display a graphical user interface comprising a plurality of patient identifiers associated with the trial; receive, from the computing device, a selection of one of the plurality of patient identifiers; receive, from the computing device, a query comprising an inquiry relating to the selected patient identifier; and transmit the query to a practice site associated with the selected patient identifier.

Abstract: Systems and methods are disclosed for selecting cohorts. In one implementation, a model-assisted selection system for identifying candidates for placement into a cohort includes a data interface and at least one processing device. The at least one processing device is programmed to access, via the data interface, a database from which feature vectors associated with an individual from among a population of individuals can be derived; derive, for the individual, one or more feature vectors from the database; provide the one or more feature vectors to a model; receive an output from the model; and determine whether the individual from among the population of individuals is a candidate for the cohort based on the output received from the model.

Abstract: A model-assisted system for determining probabilities associated with a patient attribute. The processor may be programmed to access a database storing an unstructured medical record associated with a patient and analyze the medical record to identify snippets of information associated with the patient attribute. The processor may generate, based on each snippet, a snippet vector comprising a plurality of snippet vector elements comprising weight values associated with at least one word included in the snippet. The processor may analyze the snippet vectors to generate a summary vector comprising a plurality of summary vector elements, wherein each of the plurality of summary vector elements is associated with a corresponding snippet vector element and is determined based on an analysis of the corresponding snippet vector element. The processor may further generate, based on the summary vector, at least one output indicative of a probability associated with the patient attribute.

Abstract: Systems and methods are disclosed for monitoring models for bias. In one implementation, a system for automatically assessing a deployed model for selection of a cohort may include a processing device programmed to: apply the deployed model to data representing a first plurality of individuals, the data including at least one characteristic of the first plurality of individuals; based on the application, select a subset of the first plurality of individuals as a cohort; receive data representing a second plurality of individuals labeled as within the cohort, the data including the at least one characteristic of the second plurality of individuals; compare the selected subset and the second plurality of individuals along the at least one characteristic; and determine whether the comparison results in a difference between the selected subset and the second plurality of individuals greater than a threshold.

Abstract: A model-assisted system for predicting survivability of a patient may include at least one processor. The processor may be programmed to access a database storing a medical record for the patient. The medical record may include at least one of structured and unstructured information relative to the patient and may lack a structured patient ECOG score. The processor may be further programmed to analyze at least one of the structured and unstructured information relative to the patient; based on the analysis, and in the absence of a structured ECOG score, generate a performance status prediction for the patient; and provide an output indicative of the predicted performance status. The analysis of at least one of the structured and unstructured information and the generation of the predicted performance status may be performed by at least one of a trained machine learning model or a natural language processing algorithm.

Abstract: A system for classifying patient parameter values may include at least one processor programmed to access first information associated with a plurality of patients, the first information including a plurality of patient parameters associated with the plurality of patients, the first information being accessed electronically via a database; determine a first value associated with a patient parameter of at least one of the plurality of patients; analyze second information associated with at least one patient to determine a second value of the patient parameter; detect, based on analysis of at least the first value and the second value, a potential anomaly in the second value; and cause a graphical user interface of a computing device to display at least one graphical element indicating the potential anomaly.

Abstract: A model-assisted system and method for predicting health care services. In one implementation, a model-assisted system may comprise a least one processor programmed to access a database storing a medical record associated with a patient and analyze the medical record to identify a characteristic of the patient. The processor may determine a patient risk level indicating a likelihood that the patient will require a health care service within a predetermined time period; compare the patient risk level to a predetermined risk threshold; and generate a report indicating a recommended intervention for the patient. The processor may further determine a calibration factor indicating a difference between an average patient risk level and an average actual healthcare service usage for a first group of patients; and determine, based on the calibration factor, a bias relative to a second group of patients.

Abstract: A system for generating dynamic multi-layered graphical user interfaces may include at least one processing device configured to retrieve treatment regimen data for a patient from at least one networked database, retrieve patient attribute data for the patient, generate a graphical user interface reflecting a medication identified in the treatment regimen data and one or more associated patient attributes, compare the extracted patient attributes to one or more thresholds in a rule set, the rule set correlating a dose of the medication to one or more expected values of the extracted patient attributes, evaluating at least one condition of at least rule in the rule set, generate, based on the evaluation an interactive icon for display in the graphical user interface, and generate an overlay window displayed adjacent the interactive icon, the overlay window providing details associated with the interactive icon.

Abstract: A system for classifying patient parameter values may include at least one processor programmed to access first information associated with a plurality of patients, the first information including a plurality of patient parameters associated with the plurality of patients, the first information being accessed electronically via a database; determine a first value associated with a patient parameter of at least one of the plurality of patients; analyze second information associated with at least one patient to determine a second value of the patient parameter; detect, based on analysis of at least the first value and the second value, a potential anomaly in the second value; and cause a graphical user interface of a computing device to display at least one graphical element indicating the potential anomaly.