Abstract: Provided are methods and compositions for determining an increased likelihood of prostate cancer cells in a subject to metastasize.

Abstract: Methods and systems for determining material composition of a test sample may be provided. The test sample may be placed in a magnetic region having a magnetic field. A light beam may be directed at the test sample in the magnetic region. A birefringence in the light beam that has passed through the test sample may be detected. The material composition of the test sample may be determined based on the detected birefringence in the light beam.

Abstract: Provided are methods and compositions for determining an increased likelihood of prostate cancer cells in a subject to metastasize.

Abstract: Methods for cancer diagnosis, making decisions on appropriate cancer treatment, awareness of a predisposition to cancer and potential cancer prevention, and monitoring of cancer therapy by measuring the activity of PMPMEase.

Abstract: Provided are methods and compositions for determining an increased likelihood of prostate cancer cells in a subject to metastasize.

Abstract: A method is presented for treating an inflammatory skin disorder in a human comprising: topically applying to the skin a composition comprising alpha-melanocyte stimulating hormone (?MSH) or an ?MSH analog in an amount effective to reduce skin inflammation in the human.

Abstract: Provided are methods and compositions for determining an increased likelihood of prostate cancer cells in a subject to metastasize.

Abstract: The invention describes a nutraceutical composition and method for preventing/treating cancer or augmenting chemotherapy in advanced stage malignancies; comprised of [1] tumoricidal herbs; beth root, galbanum, gromwell root, wild yam, balm of gilead bud, frankincense, [2] an antiproliferative herb; speranskia [3] a natural lactic acid dehydrogenase (LDH) inhibitor, 2?,3,4?5,7-pentahydroxyflavone or cinnamon, [4] alkalizing agents: calcium, magnesium, potassium or bicarbonate salts, barley grass, chlorella and spirulina [5] at least one quinone and [6] at least one agent capable of maximizing oxidative mitochondrial function preferably riboflavin, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin and a pharmaceutically acceptable carrier.

Abstract: Methods and formulations for treating a condition of the skin by delivering therapeutic formulations to the skin that translocates active substances across the stratum corneum barrier to a targeted skin tissue. The methods and formulations comprise active substances encapsulated within surface modified nanostructured lipid carrier nanoparticles.

Abstract: Methods for cancer diagnosis, making decisions on appropriate cancer treatment, awareness of a predisposition to cancer and potential cancer prevention, and monitoring of cancer therapy by measuring the activity of PMPMEase.

Abstract: The present invention relates to quinolinium antiinfective agents in which the qunolinium nucleus is fused to an indole ring or the qunolinium nucleus is linked to a cyclic structure through an opened indole or a benzothiophene or benzofuran ring. The compound is further substituted with various substituent groups. The compounds are represented by formula (I), (II) and (III): Pharmaceutical compositions and methods of use are also included.

Abstract: A newly discovered fungus Bipolaris imperatae which possesses herbicidal effects on grassy weed species such as cogongrass (Imperata cylindrica), methods of applying Bipolaris imperatae fungus as a mycoherbicide to control growth of cogongrass and similar wild grassy weeds, and compositions containing an effective amount of Bipolaris imperatae fungus and an agriculturally acceptable carrier to control growth of cogongrass and similar weeds.

Abstract: An indoloquinoline wherein the quarternary N-5 atom is a straight C(1-5) chain, a branched C(1-5) chain, a heteroatom chain, a straight chain substituted terminally by a cycloalkyl or aromatic ring, a branched chain substituted terminally by a cycloalkyl or aromatic ring, a heteroatom chain substituted terminally by a cycloalkyl or aromatic ring; the 10 position is N—R10, O, S, S?O, CH2, or C?O, where R10 is a branched C(1-5) chain, a heteroatom chain, a straight chain substituted terminally by a cycloalkyl or aromatic ring, a branched chain substituted terminally by a cycloalkyl or aromatic ring, a heteroatom chain substituted terminally by a cycloalkyl or aromatic ring. In one embodiment the quarternary N-5 atom is —CH3 and the 10 position is N—(CH2)5—Ph.

Abstract: An online, and therefore distributed, technology transfer department accessible by multiple inventive entities is provided. The systems and methods of the invention provide a comprehensive interface to a remote application that collects information related to inventions, ranks the inventions, solicits approval for pursuing intellectual property protection, funding, financing, commercializing or otherwise exploiting the invention, solicits bids from a stable of service providers, manages the award of contracts to provide services, facilitates collaboration between users internal and external to the inventive entities and between different entities, implements security protocols, and reports government funded inventions to the appropriate regulatory agencies, and manages intellectual property portfolios. Each inventive entity may specify the level of control to be retained to utilize the distributed technology office application as a supplement for or as a substitute for full time technology transfer personnel.

Abstract: Inhibitors of the enzyme prenylated methylated protein methyl esterase (PMPMEase), the last step in the prenylation process for many eukaryotic proteins, having the general structure R1-X-A-B(R2)-Y or R1-X-A(R2)-B-Y, where R1 is preferably a polyisoprenyl group, X is a linking group, Y is a group that promotes affinity interactions to the active site of PMPMEase and imparts hydrolysis resistance to the inhibitor, A and B are bridge atoms, and R2 is a characteristic-providing substituent.

Abstract: Inhibitors of the enzyme prenylated methylated protein methyl esterase (PMPMEase), the last step in the prenylation process for many eukaryotic proteins, having the general structure R1-X-A-B(R2)-Y or R1-X-A(R2)-B-Y, where R1 is preferably a polyisoprenyl group, X is a linking group, Y is a group that promotes affinity interactions to the active site of PMPMEase and imparts hydrolysis resistance to the inhibitor, A and B are bridge atoms, and R2 is a characteristic-providing substituent.

Abstract: A flag capable of being unfurled or crested in the wind by use of a finger or flagpole comprising: first means for attaching the flag to a finger on a hand, and adjoining second means attached to the first means for attaching the flag to a flagpole; wherein the first means for attaching the flag to a finger comprises panels that sandwich an end section of the flag comprising a tubular member integrally attached to the panels, the tubular member having an inside diameter in an unstretched mode less than the outside diameter of a finger; and the adjoining tubular second means comprises a member for attaching the flag to a flagpole, the adjoining tubular member having an inside diameter in an unstretched mode less than the outside diameter of the flagpole.

Abstract: Compositions and methods for treating a cancer in mammals by administering selective estrogen receptor modulators particularly compounds represented by: or any other of the structures contained herein, or of a stereoisomer, enantiomer, rotomer, tautomer or pharmaceutically acceptable salt form thereof.

Abstract: Threshold Cerenkov Detector With Radial Segmentation permits correlation between number of photons produced in concentrically arranged radiator tubes and particle momentum that yields a 90% confidence level for e, ?, ?, and p identification up to 4-5 GeV/c or four to five times greater than the momentum limit for particle identification in Threshold Cerenkov Detectors, wherein detector has three concentric cylinders with a total of 25 radiator tubes, each cylinder of tubes has different medium; and four scintillators are employed which trigger cosmic particles within a window of 5ns. Radiator designs produce more photons as particles enter improved TCDRS design and fewer photons as they leave. Correlation between the number of photons produced in the tubes and the particle momentum yields about a 90% confidence level for e, ?, ?, and p identification up to 4-5 GeV/c times greater than the momentum limit for particle identification using existing Threshold Cerenkov Detectors.

Abstract: A new and distinct cultivar of the muscadine grape plant, Vitis rotundifolia Michx., which has exceptionally good flavor, firm flesh texture with relatively thin skin, and a larger berry than the current grapes that are produced commercially. The vines of this cultivar are vigorous, productive and disease resistant.