Abstract: Methods and compositions comprising immunoassays for the detection of functional antibodies and the analysis of vaccine efficacy are described. In particular, the present invention provides opsonophagocytic assays. The assays are useful for the rapid and simultaneous detection of multiple different functional antibodies. In preferred embodiments, the assays include fluorescent labels of multiple colors and/or intensities.
Type:
Grant
Filed:
December 7, 2001
Date of Patent:
November 9, 2004
Assignees:
The United States of America as represented by the Department
of Health and Human Services, Flow Applications, Inc.
Inventors:
Joseph E. Martinez, George M. Carlone, Michael H. Hickey, Sandra Steiner