Abstract: Provided is a cutting biopsy instrument facilitating loading by minimizing a change in a grip on a biopsy instrument and enhancing tissue sampling accuracy and safety and simplifying collection of sampled tissue by proposing a new shift relation between an stylet and an cannula at the shooting of the needles.

Abstract: Provided is a disposable cutting biopsy device including a housing formed in a tube shape and having a sliding space therein, a needle set disposed in the housing through a front portion hole of the housing and comprising an inner needle having a tissue extraction recess to extract a tissue and an outer needle having a blade formed at a leading end to cut the tissue accommodated in the tissue extraction recess and performing a reciprocating motion along an outer circumference of the inner needle in a form of surrounding the inner needle, a sliding block connected to the outer needle and disposed to perform a reciprocating motion back and forth in the sliding space, a loading unit connected to the sliding block and shooting the sliding block, and a loading handle disposed to be connected to the loading unit, in which, when the sliding block moves backward, a first negative pressure space is formed in a front portion of the sliding space, and when the sliding block moves forward, a second negative pressure spac