Abstract: A pinch valve assembly includes a valve body having axially-aligned inlet and outlet ports, a flexible sleeve that is releasably mounted within the valve body, a mechanical pinching mechanism, and a valve casing. The flexible sleeve has a longitudinal bore defining a fluid flow path between the inlet port and the outlet port. The pinching mechanism pinches the flexible sleeve to thereby reduce the effective cross-sectional flow area thereof. The valve casing assembly substantially encloses the valve housing. The valve casing assembly includes at least one removable portion to permit access to the valve housing and the flexible sleeve, to facilitate replacement of the flexible sleeve.