Abstract: The present invention provides methods for selectively enriching a biological sample for short nucleic acids, such as fetal DNA in a maternal sample or apoptic DNA in a biological sample from a cancer patient and for subsequently analyzing the short nucleic acids for genotype, mutation, and/or aneuploidy.
Type:
Application
Filed:
May 16, 2011
Publication date:
August 14, 2014
Applicant:
FLUIDIGM, INC.
Inventors:
Andrew May, Alain Mir, Ramesh Ramakrishnan, Bernhard G. Zimmermann
Abstract: The present invention provides amplification-based methods for detection of genotype, mutations, and/or aneuploidy. These methods have broad applicability, but are particularly well-suited to detecting and quantifying target nucleic acids in free fetal DNA present in a maternal bodily fluid sample.
Type:
Application
Filed:
May 16, 2011
Publication date:
July 3, 2014
Applicant:
FLUIDIGM, INC.
Inventors:
Martin Pieprzyk, Robert C. Jones, Kenneth J. Livak, Andrew May, Alain Mir, Jian Qin, Ramesh Ramakrishnan, Sandra Spurgeon, Jun Wang, Bernhard G. Zimmermann