Abstract: The present invention refers to plasticizers derived from vegetable oils for thermoplastic polymers and resins, in particular, plasticizers for Polyvinylchloride (PVC). Furthermore, the invention relates to a method for preparing such plasticizers. Plasticizers comprise esters of carboxyl fatty acids wherein fatty acids are selected from those having a hydrocarbon chain comprised between C12 e C22, wherein the double bonds of the hydrocarbon chain of the carboxylic fatty acid are epoxidized, and the esterification is with a cyclic acetal or ketal.