Abstract: Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A3 adenosine receptors and act as A3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.
Type:
Grant
Filed:
March 7, 2007
Date of Patent:
April 28, 2015
Assignees:
FM Therapeutics Co., Ltd., The United States of America, As Represented by the Secretary, Department of Health and Human Services, The Office of Technology Transfer, National Institutes of Health
Inventors:
Lak Shin Jeong, Hea Ok Kim, Kenneth A. Jacobson, Seung Ah Choe
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