Patents Assigned to FoldRx Pharmaceuticals, Inc.
  • Compounds, compositions and methods of inhibiting alpha-synuclein toxicity
    Patent number: 8440705
    Abstract: Compounds and compositions are provided for treatment or amelioration of one or more symptoms of ?-synuclein toxicity, ?-synuclein mediated diseases or diseases in which ?-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihydropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: May 14, 2013
    Assignees: Whitehead Institute for Biomedical Research, FoldRx Pharmaceuticals, Inc.
    Inventors: Susan L. Lindquist, Tiago Outeiro, Richard Labaudinière
  • Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
    Patent number: 8338459
    Abstract: Compounds, compositions and methods are provided for stabilizing transthyretin and for treating, preventing, or ameliorating one or more symptoms of transthyretin mediated diseases. In one embodiment, the compounds are benzoxazoles and related compounds.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: December 25, 2012
    Assignee: FoldRx Pharmaceuticals, Inc.
    Inventor: Richard Labaudinière
  • Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
    Patent number: 7868033
    Abstract: Compounds, compositions and methods are provided for stabilizing transthyretin and for treating, preventing, or ameliorating one or more symptoms of transthyretin mediated diseases. In one embodiment, the compounds are benzoxazoles and related compounds.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: January 11, 2011
    Assignee: FoldRx Pharmaceuticals, Inc.
    Inventor: Richard Labaudiniere
  • MODULATION OF PROTEIN TRAFFICKING
    Publication number: 20100331297
    Abstract: Compounds and compositions are provided for treatment or amelioration of one or more disorders characterized by defects in protein trafficking. A method of treating a disorder characterized by impaired protein trafficking includes administering to a subject or contacting a cell with a compound of Formula I: [formula here] or pharmaceutically acceptable salts or derivatives thereof.
    Type: Application
    Filed: November 7, 2008
    Publication date: December 30, 2010
    Applicant: FOLDRX PHARMACEUTICALS, INC.
    Inventors: Christine Ellen Bulawa, Michael DeVit, Daniel Elbaum
  • COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING
    Publication number: 20100305068
    Abstract: Disclosed are compositions and methods for modulating protein trafficking and treating or preventing disorders characterized by impaired protein trafficking. Also disclosed are methods for producing a protein and identifying compounds that rescue protein trafficking defects.
    Type: Application
    Filed: November 9, 2007
    Publication date: December 2, 2010
    Applicant: FoldRx Pharmaceuticals, Inc.
    Inventors: Christine Bulawa, James Fleming
  • INHIBITION OF ALPHA-SYNUCLEIN TOXICITY
    Publication number: 20100273776
    Abstract: Compounds and compositions are provided for treatment or amelioration of one or more symptoms of ?-synuclein toxicity, ?-synuclein mediated diseases or diseases in which ?-synuclein fibrils are a symptom or cause of the disease.
    Type: Application
    Filed: March 29, 2007
    Publication date: October 28, 2010
    Applicants: FOLDRx PHARMACEUTICALS, INC, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Susan L. Lindquist, Tiago Outeiro, Richard Labaudinière, James Fleming, Christine Ellen Bulawa, Charlotte Weigel, Feng Liang, Sandeep Gupta, Amy Ripka
  • CELLS EXPRESSING ALPHA-SYNUCLEIN AND USES THEREFOR
    Publication number: 20100122362
    Abstract: Disclosed are mammalian neuronal cells expressing alpha synuclein as well as methods of screening to identify compounds that decrease toxicity induced by alpha synuclein expression. Compounds identified by such screens can be used to treat or prevent synucleinopathies such as Parkinson's disease, familial Parkinson's disease, Lewy body disease, the Lewy body variant of Alzheimer's disease, dementia with Lewy bodies, multiple system atrophy, or the Parkinsonism-dementia complex of Guam.
    Type: Application
    Filed: October 12, 2007
    Publication date: May 13, 2010
    Applicant: FoldRx Pharmaceuticals, Inc.
    Inventor: Feng Liang
  • COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING
    Publication number: 20100004277
    Abstract: Disclosed are compositions and methods for modulating protein trafficking and treating or preventing disorders characterized by impaired protein trafficking. Also disclosed are methods for identification of compounds that rescue protein trafficking defects and methods of enhancing protein production.
    Type: Application
    Filed: January 26, 2007
    Publication date: January 7, 2010
    Applicant: FoldRx Pharmaceuticals, Inc.
    Inventors: Christine Bulawa, Michael DeVit
  • Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity
    Publication number: 20080261953
    Abstract: Compounds and compositions are provided for treatment or amelioration of one or more symptoms of ?-synuclein toxicity, ?-synuclein mediated diseases or diseases in which ?-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihy-dropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.
    Type: Application
    Filed: September 16, 2005
    Publication date: October 23, 2008
    Applicants: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, FOLDRX PHARMACEUTICALS, INC.
    Inventors: Susan L. Lindquist, Tiago Outeiro, Richard Labaudiniere
  • ASSAYS FOR DETECTING NATIVE-STATE PROTEINS AND IDENTIFYING COMPOUNDS THAT MODULATE THE STABILITY OF NATIVE-STATE PROTEINS
    Publication number: 20080131907
    Abstract: This invention relates to assays for detecting native-state proteins and to screening methods to identify compounds that modulate the stability of the native-state of proteins. Compounds identified by such screens can be used to treat diseases associated with protein misfolding, such as Alzheimer's Disease, familial amyloidotic polyneuropathies, and lysosomal storage diseases.
    Type: Application
    Filed: September 14, 2007
    Publication date: June 5, 2008
    Applicant: FoldRx Pharmaceuticals, Inc.
    Inventors: Lan Wang, Christine Bulawa