Abstract: The invention provides a class of oligonucleotide that is optimized to target a specific RNA for RNAse H degradation and to be itself resistant to degradation within in plasma and within eukaryotic, especially mammalian cells. The oligonucleotides of the invention contain no naturally occurring 5′→3′-linked nucleotides. Rather, the invention provides oligonucleotides having two types of nucleotides: 2′-deoxyphosphorothioate, which activate RNase H, and 2′-modified nucleotides, which do not. The linkages between the 2′-modified nucleotides can be phosphodiesters, phosphorothioate or P-ethoxyphosphodiester. Activation of RNAse H is accomplished by a contiguous, RNAse H-activating region, which contains between three and five 2′-deoxyphosphorothioate nucleotides to activate bacterial RNAse H and between five and ten 2′-deoxyphosphorothioate nucleotides to activate eukaryotic and, particularly, mammalian RNAse H.

Abstract: A shift lever boot includes a top face having a shift lever hole face and including a plurality of crests and a plurality of valleys, and a bellow-like skirt continuously connected to edges of the top face. All ridgelines of the crests and the valleys are parallel with respect to the cross direction of a motor vehicle.

Abstract: The invention relates to a steering wheel with at least one covering element, which is preferably affixed above an insert of the steering wheel rim (3). According to the invention, at least one mechanical connecting element (11), in particular a clip-type connecting part, is placed between the steering wheel (1) and the covering element (5, 6).

Abstract: A vehicle stability apparatus and method with an on-off-switch, to prevent the driving road wheel from applying excessive braking force when the traction control apparatus is off. When a selectable switch is selected off, a control unit does not exert the traction control to decrease the engine output power to restrain the driving wheels slip even if driving wheel slip is generating. Then the control unit exerts the yaw moment control apparatus for optimizing vehicle stability to control wheel braking force of respective road wheels, and the control unit compulsory exerts the traction control during generating wheel slip irrespective of the switch.

Abstract: A new and distinct cultivar of geranium plant named ‘Fischerry’, as described and illustrated, and particularly characterized by the combined features of light-red to cherry-red flower color; numerous compact inflorescences; light, medium green, slightly zoned foliage; medium-tall; well-branched; round, only semi-trailing plant habit; and early spring flowering response.