Abstract: The present invention relates to the use of N,O oversulfated K5 derivatives having a degree of sulfation higher than 3.2 or of their pharmaceutically acceptable salts for the preparation of pharmaceutical compositions for treating the infection and the consequent HIV/ADS disease.
Type:
Grant
Filed:
July 26, 2002
Date of Patent:
September 11, 2007
Assignees:
Fondazione Centro San Raffaele Del Monte Tabor
Inventors:
Giorgio Zoppetti, Pasqua Anna Oreste, Guido Poli, Elisa Vicenzi
Abstract: RANTES mutants characterised by the substitution or addition of amino acids at the N-terminal of RANTES wild-type sequence and in the N-loop and/or 40's loop regions of RANTES wild-type sequence, and their use as anti-HIV, anti-allergic or anti-inflammatory agents.
Type:
Grant
Filed:
March 28, 2003
Date of Patent:
January 16, 2007
Assignee:
Fondazione Centro San Raffaele Del Monte Tabor
Abstract: Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents ate disclosed.
Type:
Grant
Filed:
April 30, 2003
Date of Patent:
September 19, 2006
Assignee:
Fondazione Centro San Raffaele Del Monte Tabor
Abstract: Provided herein is a method for the quantitative detection of nucleic acids based on the use of a calibrator, suitable primers and probes, and a nucleic acid polymerase with 5?-3? nuclease activity.
Type:
Grant
Filed:
November 17, 1999
Date of Patent:
April 18, 2006
Assignee:
Fondazione Centro San Raffaele Del Monte Tabor
Inventors:
Giuseppe Locatelli, Paolo Lusso, Mauro Malnati, Francesca Salvatori, Gabriella Scarlatti
Abstract: Peptides having 12 to 30 amino acids with sequence homologous or corresponding to the sequence 1o-34 of RANTES having inhibitory activity against the human immunodeficiency virus (HIV) as well as anti-allergic and antiinflamatory activity.
Type:
Grant
Filed:
June 22, 2001
Date of Patent:
March 23, 2004
Assignees:
Fondazione Centro San Raffaele Del Monte Tabor, PRIMM S.r.l.
Abstract: RANTES mutants characterized by the substitution or addition of amino acids at the N-terminal or RANTES wild-type sequence and in the N loop and/or 40′ loop regions of RNATES wild-type sequence, and their use as anti-HIV, anti-allergic or anti-inflammatory agents.
Type:
Grant
Filed:
June 9, 2000
Date of Patent:
August 19, 2003
Assignee:
Fondazione Centro San Raffaele del Monte Tabor
Abstract: Peptides comprising the SRSRY sequence (SEQ ID NO: 7) derived from the uPAR (urokinase receptor) are endowed with chemotactic activity, making them useful for preventing or activating the migration of cells in a mammal. More particularly, the peptides of the invention are useful for the treatment of cancer, autoimmune diseases, and/or hyperinflammatory diseases and for stimulating wound healing.
Type:
Grant
Filed:
October 20, 1999
Date of Patent:
October 8, 2002
Assignees:
Fondazione Centro San Raffaele del Monte Tabor, Universita Degli Studi di Milano
Inventors:
Francesco Blasi, Francesca Fazioli, Massimo Resnati, Nicolai Sidenius