Abstract: RANTES mutants characterized by the substitution or addition of amino acids at the N-terminal or RANTES wild-type sequence and in the N loop and/or 40′ loop regions of RNATES wild-type sequence, and their use as anti-HIV, anti-allergic or anti-inflammatory agents.
Type:
Grant
Filed:
June 9, 2000
Date of Patent:
August 19, 2003
Assignee:
Fondazione Centro San Raffaele del Monte Tabor
Abstract: Peptides comprising the SRSRY sequence (SEQ ID NO: 7) derived from the uPAR (urokinase receptor) are endowed with chemotactic activity, making them useful for preventing or activating the migration of cells in a mammal. More particularly, the peptides of the invention are useful for the treatment of cancer, autoimmune diseases, and/or hyperinflammatory diseases and for stimulating wound healing.
Type:
Grant
Filed:
October 20, 1999
Date of Patent:
October 8, 2002
Assignees:
Fondazione Centro San Raffaele del Monte Tabor, Universita Degli Studi di Milano
Inventors:
Francesco Blasi, Francesca Fazioli, Massimo Resnati, Nicolai Sidenius