Abstract: A drug based on a metabolite of fenretinide, or N-(4hydroxyphenyl) retinamide (4-HPR), specifically 4-oxo-N-(4-hydroxyphenyl) retinamide (4-oxo-4-HPR), is used in the treatment of different kinds of tumors, in particular in the treatment of ovarian carcinoma, breast tumor and neuroblastoma. The drug is more potent than fenretinide alone, and enhances the effects of fenretinide when administered together with fenretinide.
Type:
Grant
Filed:
March 18, 2004
Date of Patent:
January 30, 2007
Assignee:
Fondazione IRCCS “Istituto Nazionale Dei Tumori”