Patents Assigned to Fondazione Istituto Italiano di Tecnologia
  • ARTIFICIAL HAND
    Publication number: 20190269528
    Abstract: An artificial hand is provided. The artificial includes phalanges suitable to reproduce at least one finger, hinges hinging a first element identifying a phalanx to a second element identifying a second phalanx, and an implementation mechanism suitable to command a reciprocal rotation between the hinges defining a mutual rotation speed between the first and second element. The hinges define different damping coefficients so that, during a mutual rotation of the first and second element, they are subject to distinct damping forces opposing mutual rotation and proportional to the mutual rotation speed so as to vary the movement of the artificial hand as a function of the mutual rotation speed.
    Type: Application
    Filed: May 9, 2017
    Publication date: September 5, 2019
    Applicants: UNIVERSITA' DI PISA, FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Antonio BIICCHI, Manuel Giuseppe CATALANO, Giorgio GRIOLI, Manolo GARABINI, Cristina PIAZZA, Cosimo DELLA SANTINA
  • Optogenetic tool for multiple and independently addressing of patterned optical windows
    Patent number: 10398293
    Abstract: A multi-point light-delivering device, comprising a waveguide carrying light along a longitudinal axis and including multiple optical windows, through which the carried light is out-coupled from the waveguide. The waveguide comprises a tapered region along which the optical windows are distributed, wherein each optical window out-couples a specific subset of propagating modes of the carried light, to which the optical window is matched.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: September 3, 2019
    Assignees: Fondazione Istituto Italiano di Tecnologia, President and Fellows of Harvard College
    Inventors: Ferruccio Pisanello, Luigi Martiradonna, Leonardo Sileo, Ian Anton Oldenburg, Marco Pisanello, Bernardo Luis Sabatini, John Abraham Assad, Massimo De Vittorio
  • Method for producing shaped polymeric microparticles
    Patent number: 10384372
    Abstract: Method for producing shaped polymeric microparticles of non-spherical shape, comprising the steps of: placing one or more microparticles of substantially spherical shape in a respective micro-cavity of a mold having the desired non-spherical shape; subjecting said microparticles to softening by exposure to a solvent or mixture of solvent/non-solvent, in the liquid or vapor state, adapted to plasticize the polymeric material constituting said microparticles, and possibly assisting the solvent plasticization process by heat treatment, not excluding the possibility, in less critical cases in terms of conservation of the microstructure, of carrying out heat treatment exclusively, at a temperature not exceeding 40% of the glass transition temperature of the polymer material; and removing said microparticles from the mold cavities.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: August 20, 2019
    Assignee: Fondazione Istituto Italiano di Tecnologia
    Inventors: Raffaele Vecchione, Renato De Alteriis, Paolo Antonio Netti
  • Modulation of N-acylethanolamine-hydrolysing acid amidase (NAAA) for disease treatment
    Patent number: 10364242
    Abstract: Pharmaceutical compositions make up a compound acting as inhibitor of N-acylethanolamine-hydrolyzing acid amidase (NAAA), may be used for the therapeutical treatment and prevention of pain and inflammatory disorders and other disorders which benefit from the modulation of fatty acid ethanolamines, particularly palmitoylethanolamide (PEA). The compound is used in methods of inhibiting NAAA and methods of therapeutical treatment and prevention of pain and inflammation.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: July 30, 2019
    Assignee: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Fabio Bertozzi, Tiziano Bandiera
  • miRNA PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC USES THEREOF
    Publication number: 20190209602
    Abstract: Pharmaceutical compositions are provided which include a microRNA pool capable of promoting, stimulating or increasing neuronal differentiation, as well as methods for treating, ameliorating and/or preventing depression or diseases where damage to nervous tissue occurs, such as neurological diseases, by means of such microRNA pool.
    Type: Application
    Filed: September 18, 2017
    Publication date: July 11, 2019
    Applicant: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Davide DE PIETRI TONELLI, Meritxell PONS ESPINAL
  • DISPLAY INCLUDING A PLURALITY OF LIGHT SOURCES AND A PLURALITY OF WAVEGUIDES
    Publication number: 20190154902
    Abstract: A display including: a plurality of light sources that emit light beams; a plurality of optical cores having an elongated shape, each optical core having a respective first end, which is optically coupled to a corresponding light source, each optical core further being such that the light beam emitted from the corresponding light source propagates in a guided manner inside the optical core; and a screen, each optical core having a respective second end, which is optically coupled to the screen. The display further includes an optical separation element, which forms a plurality of cavities that house corresponding optical cores, each cavity and the corresponding optical core forming a corresponding waveguide. The optical separation element absorbs visible light and laterally surrounds at least the first end of each optical core.
    Type: Application
    Filed: June 20, 2017
    Publication date: May 23, 2019
    Applicant: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Marco Maggiali, Giorgio Metta
  • Method for the preparation of polyaniline/reduced graphene oxide composites
    Patent number: 10253155
    Abstract: The present invention concerns a method for obtaining polyaniline/reduced graphene oxide composites comprising the steps of dispersing the graphene oxide in an acid aqueous solution containing an emulsifying agent to obtain a graphene oxide dispersion; dissolving one or more aniline oligomers in an organic solvent to obtain an oligomer solution; mixing the oligomer solution with the graphene oxide dispersion, said oligomer being added in a stoichiometric excess compared to the quantity required to complete the graphene oxide reduction; adding to the suspension of the polyaniline/reduced graphene oxide composite an oxidizing agent in a stoichiometric quantity compared to said excess of oligomer so as to oxidize the excess of said oligomer to obtain a suspension of the polyaniline/reduced graphene oxide composite.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: April 9, 2019
    Assignee: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Sergio Bocchini, Alessandro Chiolerio, Samuele Porro
  • Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
    Patent number: 10226452
    Abstract: The present invention relates to benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides benzoxazolone derivatives for use as a medicament in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: March 12, 2019
    Assignees: The Regents of the University of California, Fondazione Istituto Italiano di Tecnologia
    Inventors: Daniele Piomelli, Chiara Pagliuca, Daniela Pizzirani, Anders Bach, Natalia Realini, Marco De Vivo
  • METHOD FOR THE OPTOINJECTION OF EXOGENOUS MATERIAL INTO A BIOLOGICAL CELL
    Publication number: 20190017071
    Abstract: A method for the optoinjection of exogenous material in a recipient biological cell is disclosed and comprises: placing a biological cell on a planar surface of a substrate, transmitting a sub-ns pulsed laser beam through a variable convergence/divergence collimator; focusing the laser beam in a focal spot positioned along an axial direction substantially perpendicular to the substrate; moving the focal spot towards the cell along the axial direction by continuously varying the electric control signal from a first amplitude value a second amplitude value the second amplitude value of the control signal is selected such that the second axial position is positioned inside the cell.
    Type: Application
    Filed: December 20, 2016
    Publication date: January 17, 2019
    Applicant: Fondazione Istituto Italiano di Tecnologia
    Inventors: Francesco Difato, Alessandro Soloperto, Gemma Palazzolo
  • Masked cation exchange lithography
    Patent number: 10160906
    Abstract: We describe a method for patterning of colloidal nanocrystals films that combines a high energy beam treatment with a step of cation exchange. The high energy irradiation causes cross-linking of the ligand molecules present at the nanocrystal surface, and the cross-linked molecules act as a mask for the subsequent cation exchange reaction. Consequently, in the following step of cation exchange, the regions that have not been exposed to beam irradiation are chemically transformed, while the exposed ones remain unchanged. This selective protection allows the design of patterns that are formed by chemically different nanocrystals, yet in a homogeneous nanocrystal film.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: December 25, 2018
    Assignee: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Roman Krahne, Karol Miszta, Andrea Toma, Fanny Greullet, Sergio Marras, Mirko Prato, Milena Arciniegas, Liberato Manna
  • METHOD FOR THE SYNTHESIS OF METAL NANOPARTICLES IN AQUEOUS ENVIRONMENT WITHOUT THE USE OF SHAPE DIRECTING AGENTS
    Publication number: 20180361482
    Abstract: The present disclosure relates to a seed-growth based method for the synthesis of metal nanoparticles of controlled shape (cubes, cuboids, octahedrons) and size in an aqueous environment, without the use of shape directing agents. The method involves a first step of preparing a solution comprising water, metal seed growth nanoparticles, a metal salt comprising the same metal as the metal seed growth nanoparticles, and a reducing agent; and a second step of heating the solution to between 9 and 130° C. at a rate of between 1° C./min and 5° C./min and at a pressure of between 1 and 5 atm. The method may also be carried out in a reduced oxygen atmosphere and the concentration of oxygen disclosed in the solution may be less than the concentration of oxygen in an oxygen saturated solution.
    Type: Application
    Filed: December 14, 2016
    Publication date: December 20, 2018
    Applicant: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Mauro Moglianetti, Pier Paolo Pompa
  • METHODS AND KITS FOR NUCLEIC ACID DETECTION
    Publication number: 20180346974
    Abstract: Methods for detecting DNA or RNA target nucleic acids are provided. Such methods are based on isothermal amplification of nucleic acids mediated by cooperative hybridization, designated as exponential CHAMP. Kits for implementing methods for detecting DNA or RNA target nucleic acids based on isothermal amplification of nucleic acids mediated by cooperative hybridization are also provided.
    Type: Application
    Filed: November 17, 2016
    Publication date: December 6, 2018
    Applicant: Fondazione Istituto Italiano di Tecnologia
    Inventors: Pier Paolo POMPA, Paola VALENTINI
  • Hollow nanoparticles having a modulable metal core
    Patent number: 10124407
    Abstract: The present invention relates to hollow nanoparticles having inside their cavity a metal core constituted by metal seeds agglomerated with a cationic polyelectrolyte, useful in medicine as well as in the bio-imaging and/or radio-therapeutic or chemo-therapeutic techniques and also in the industry as starting materials for preparing catalysts or metamaterials in non-linear optical processes.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: November 13, 2018
    Assignee: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Valerio Voliani, Vincenzo Piazza
  • UNDERACTUATED ROBOTIC HAND
    Publication number: 20180311827
    Abstract: Provided is a robotic hand which includes a palm, a plurality of phalanges adapted to reproduce a plurality of fingers, and an actuating mechanism. The actuating mechanism may include a first pulley located at each hinge and bound to the first element, second pulleys located at each of the hinges and bound to the second element, a single cable running in all of the pulleys and a motor adapted to act on the cable by controlling the rotation of the phalanges.
    Type: Application
    Filed: October 27, 2016
    Publication date: November 1, 2018
    Applicants: UNIVERSITA' DI PISA, FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Antonio BICCHI, Cosimo DELLA SANTINA, Alberto BRANDO, Cristina PIAZZA, Manuel Giuseppe CATALANO, Giorgio GRIOLI
  • OPTICAL ADAPTER CONNECTABLE TO AN IMAGE ACQUISITION DEVICE, IN PARTICULAR INTENDED TO BE USED FOR MICROSCOPIC OBSERVATION
    Publication number: 20180307029
    Abstract: An optical adapter includes a support, which can be removably coupled to an image acquisition device. The support has a substrate made of substantially transparent material. The substrate has a proximal surface intended for facing towards the device and a distal surface located at a distance from the proximal surface and intended for facing towards an object to be observed. The support also has a lens located in a seat obtained in the substrate and facing towards the objective of the device. In addition, the support has a reflector located laterally relative to the lens and arranged for facing towards a light source integrated into the device and conveying the light emitted by the light source in a transversal direction towards the lens and past the distal surface.
    Type: Application
    Filed: October 19, 2016
    Publication date: October 25, 2018
    Applicant: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Tommaso FELLIN, Andrea ANTONINI
  • Method for the preparation of polyaniline/reduced graphene oxide composites
    Patent number: 10087335
    Abstract: Methods for obtaining composites of polyaniline and reduced graphene oxide are disclosed. The methods include dispersing graphene oxide in an acid aqueous solution containing an anionic emulsifying agent to obtain a dispersion of the graphene oxide, dissolving an aniline oligomer in an organic solvent to obtain a solution of the oligomer, and mixing the solution of the oligomer with the dispersion of graphene oxide to obtain a composite of polyaniline and reduced graphene oxide. The methods may also include recovering a precipitate of the polyaniline/reduced graphene oxide composite, and dissolving the precipitate in an organic solvent to form a conductive ink or an ink for electronic devices.
    Type: Grant
    Filed: July 4, 2014
    Date of Patent: October 2, 2018
    Assignee: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Sergio Bocchini, Alessandro Chiolerio, Samuele Porro
  • PACKAGING LABEL AND METHOD FOR LABELLING A PACKAGE
    Publication number: 20180240376
    Abstract: Packaging label (1) comprising a substrate (10), a display (6) placed above the substrate (10), a control module (4) placed in electrical contact with the display (6) and adapted to control the operation of said display (6), at least one photovoltaic module (2) placed above the substrate (10) and next to the display (6) and predisposed to supply the display (6) and the control module (4); wherein the photovoltaic module (2), the control module (4) and the display (6) are printed on the substrate (10) using a printing ink mixed with dopants.
    Type: Application
    Filed: May 19, 2016
    Publication date: August 23, 2018
    Applicants: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, POLITECNICO DI MILANO
    Inventors: Mario CAIRONI, Marco CARVELLI, Antonio IACCHETTI, Giorgio DELL'ERBA
  • Distal scanning module, in particular to control the aiming and the movement of an optical apparatus of a medical device, such as a diagnostic or surgical instrument
    Patent number: 10045684
    Abstract: A module includes an oblong structure; an optical apparatus associated with the oblong structure for facing a segment arranged inside a body cavity of a patient. An actuating device is for controlling the position of the oblong structure so as to orient the optical apparatus in the body cavity. The oblong structure has a proximal portion and an end portion, which is deformable, so as to tend to remain in and elastically return to a bent condition, in which it is normally flexed. The actuating device includes a pusher member, which moves in a guided manner relative to the oblong structure and is suited to act upon the end portion, so as to angularly move it from the bent condition towards a substantially straight condition.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: August 14, 2018
    Assignee: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Emidio Olivieri, Darwin Caldwell, Leonardo De Mattos
  • Diarylalkylamine REV-ERB antagonists and their use as medicaments
    Patent number: 9949968
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and proapoptotic agents for cancer therapy.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: April 24, 2018
    Assignee: Fondazione Istituto Italiano Di Tecnologia
    Inventors: Benedetto Grimaldi, Esther Torrente, Rita Scarpelli, Giovanni Bottegoni, Tiziano Bandiera, Marina Veronesi
  • Robot
    Patent number: D826303
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: August 21, 2018
    Assignee: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Giorgio Metta, Alberto Parmiggiani